Results 21 to 30 of about 84,776 (346)
Nature Immunology, 2022 Immune aging combines cellular defects in adaptive immunity with the activation of pathways causing a low-inflammatory state. Here we examined the influence of age on the kinetic changes in the epigenomic and transcriptional landscape induced by T cell ...
Hui-Min Zhang +11 more
semanticscholar +1 more source
Frontiers in Immunology, 2023 Foxp3 is regarded as the major transcription factor for T regulatory (Treg) cells and expression of Foxp3 is used to identify and quantitate Treg cells in mouse models.
Lyra Morina +8 more
semanticscholar +1 more source
3dgeo-heidelberg/helios: Version 1.0.0
, 2021 First public release of HELIOS++. HELIOS++ releases come with a compiled version of the Wiki, available in the "wiki" subfolder. We recommend this as a starting point for new users, or users wanting to adapt existing HELIOS projects to HELIOS++.
Alberto Manuel Esmorís Pena +6 more
core +1 more source
Differences in Expression Level of Helios and Neuropilin-1 Do Not Distinguish Thymus-Derived from Extrathymically-Induced CD4+Foxp3+ Regulatory T Cells. [PDF]
PLoS ONE, 2015 Helios transcription factor and semaphorin receptor Nrp-1 were originally described as constitutively expressed at high levels on CD4+Foxp3+ T regulatory cells of intrathymic origin (tTregs). On the other hand, CD4+Foxp3+ Tregs generated in the periphery
Edyta Szurek +6 more
doaj +1 more source
Helios: Heterogeneous Lidar Place Recognition via Overlap-Based Learning and Local Spherical Transformer [PDF]
IEEE International Conference on Robotics and AutomationLiDAR place recognition is a crucial module in localization that matches the current location with previously observed environments. Most existing approaches in LiDAR place recognition dominantly focus on the spinning type LiDAR to exploit its large FOV ...
Min-Woo Jung +3 more
semanticscholar +1 more source
Human Blood and Mucosal Regulatory T Cells Express Activation Markers and Inhibitory Receptors in Inflammatory Bowel Disease. [PDF]
PLoS ONE, 2015 FOXP3+ regulatory T cells (Tregs) are critical for preventing intestinal inflammation. However, FOXP3+ T cells are paradoxically increased in the intestines of patients with the inflammatory bowel disease (IBD) ulcerative colitis (UC) or Crohn's disease (
James D Lord +3 more
doaj +1 more source
Computer Science, 2012 HELIO [8] is a project funded under the FP7 program for the discovery and analysis of data for heliophysics. During its development, standards and common frameworks were adopted in three main areas of the project: query services, processing services, and the security infrastructure.
G Pierantoni, B Coghlan, E Kenny
openaire +6 more sources
Acute pharmacological degradation of Helios destabilizes regulatory T cells
Nature Chemical Biology, 2021 The zinc-finger transcription factor Helios is critical for maintaining the identity, anergic phenotype and suppressive activity of regulatory T (Treg) cells. While it is an attractive target to enhance the efficacy of currently approved immunotherapies,
Eric S. Wang +11 more
semanticscholar +1 more source
Alternative Splice Variants Modulates Dominant-Negative Function of Helios in T-Cell Leukemia. [PDF]
PLoS ONE, 2016 The molecular defects which lead to multistep incidences of human T-cell leukemia have yet to be identified. The DNA-binding protein Helios (known as IKZF2), a member of the Ikaros family of Krüppel-like zinc-finger proteins, functions pivotally in T ...
Shaorong Zhao +9 more
doaj +1 more source