Results 1 to 10 of about 39,970 (276)

Characterization of the sialic acid binding activity of influenza A viruses using soluble variants of the H7 and H9 hemagglutinins.

PLoS ONE, 2014
Binding of influenza viruses to target cells is mediated by the viral surface protein hemagglutinin. To determine the presence of binding sites for influenza A viruses on cells and tissues, soluble hemagglutinins of the H7 and H9 subtype were generated ...
Anne-Kathrin Sauer, Chi-Hui Liang, Jürgen Stech, Ben Peeters, Pascale Quéré, Christel Schwegmann-Wessels, Chung-Yi Wu, Chi-Huey Wong, Georg Herrler   +8 more
doaj   +2 more sources

Generation of a protective murine monoclonal antibody against the stem of influenza hemagglutinins from group 1 viruses and identification of resistance mutations against it.

PLoS ONE, 2019
Vaccines that elicit broadly cross-neutralizing antibodies, including antibodies that target the conserved stem of hemagglutinin (HA), are being developed as a strategy for next-generation influenza vaccines that protect against influenza across multiple
Wei Wang, Russell Vassell, Hyo Sook Song, Qiong Chen, Paul W Keller, Swati Verma, Esmeralda Alvarado-Facundo, Hongquan Wan, Falko Schmeisser, Clement A Meseda, Jerry P Weir, Carol D Weiss   +11 more
doaj   +2 more sources

Neutralizing immune responses induced by oligomeric H5N1-hemagglutinins from plants

Veterinary Research, 2017
Plant-based transient expression is an alternative platform to produce hemagglutinin-based subunit vaccines. This production system provides not only fast and effective response in the context of a pandemic but also enables the supply of big volume ...
Hoang Trong Phan, Thuong Thi Ho, Ha Hoang Chu, Trang Huyen Vu, Ulrike Gresch, Udo Conrad   +5 more
doaj   +2 more sources

Laboratory approaches in desensitization for ABO-incompatible transplantation [PDF]

Clinical Transplantation and Research
ABO-incompatible transplantation, once considered contraindicated due to the risk of hyperacute rejection, has become a viable option owing to advances in immunosuppression and desensitization methods. Accurate measurement and effective reduction of anti-
Kyung-Hwa Shin, Hyun-Ji Lee
doaj   +2 more sources

Stability of rubella hemagglutinin [PDF]

Applied Microbiology, 1968
R R Rafajko, S Polakavetz, Beverly Handelman, D zur Nedden   +3 more
openalex   +3 more sources

Broadly protective monoclonal antibodies against H3 influenza viruses following sequential immunization with different hemagglutinins.

PLoS Pathogens, 2010
As targets of adaptive immunity, influenza viruses are characterized by the fluidity with which they respond to the selective pressure applied by neutralizing antibodies.
Taia T Wang, Gene S Tan, Rong Hai, Natalie Pica, Erin Petersen, Thomas M Moran, Peter Palese   +6 more
doaj   +2 more sources

Influenza C virus hemagglutinin: comparison with influenza A and B virus hemagglutinins [PDF]

Journal of Virology, 1984
The complete nucleotide sequence of the influenza C/California/78 virus RNA 4 was obtained by using cloned cDNA derived from the RNA segment. This gene is 2,071 nucleotides long and can code for a polypeptide of 654 amino acids. Although there are no convincing sequence homologies between RNA 4 and the hemagglutinin genes of influenza A and B viruses ...
S, Nakada, R S, Creager, M, Krystal, R P, Aaronson, P, Palese   +4 more
openaire   +3 more sources

Immunogenicity of chimeric hemagglutinins delivered by an orf virus vector platform against swine influenza virus [PDF]

Frontiers in Immunology
Orf virus (ORFV) is a large DNA virus that can harbor and efficiently deliver viral antigens in swine. Here we used ORFV as a vector platform to deliver chimeric hemagglutinins (HA) of Influenza A virus of swine (IAV-S). Vaccine development against IAV-S
Gabriela Mansano do Nascimento, Pablo Sebastian Britto de Oliveira, Pablo Sebastian Britto de Oliveira, Salman Latif Butt, Diego G. Diel   +4 more
doaj   +2 more sources

Human Immunity and Susceptibility to Influenza A(H3) Viruses of Avian, Equine, and Swine Origin

Emerging Infectious Diseases, 2023
Influenza A viruses (IAVs) of subtype H3 that infect humans are antigenically divergent from those of birds, horses, and swine. Human immunity against these viruses might be limited, implying potential pandemic risk. To determine human risk, we selected
Elien Vandoorn, Wojciech Stadejek, Isabel Leroux-Roels, Geert Leroux-Roels, Anna Parys, Kristien Van Reeth   +5 more
doaj   +1 more source

Porphyromonas gingivalis-Helicobacter pylori co-incubation enhances Porphyromonas gingivalis virulence and increases migration of infected human oral keratinocytes

Journal of Oral Microbiology, 2022
Background Porphyromonas gingivalis is part of the subgingival biofilm and a keystone species in the development of periodontitis. Interactions between P.gingivalis and other bacteria in biofilms have been shown to affect bacterial virulence ...
Cristopher Soto, Victoria Rojas, Lucas Yáñez, Antonio Hidalgo, Marcela Olivera, Martín Pacheco, Darna Venegas, Daniela Salinas, Denisse Bravo, Andrew F.G. Quest   +9 more
doaj   +1 more source