Results 51 to 60 of about 6,574 (157)

A Human Monoclonal Antibody with Neutralizing Activity against Highly Divergent Influenza Subtypes [PDF]

, 2011
The interest in broad-range anti-influenza A monoclonal antibodies (mAbs) has recently been strengthened by theidentification of anti-hemagglutinin (HA) mAbs endowed with heterosubtypic neutralizing activity to be used in the designof ‘‘universal ...
BURIONI, ROBERTO, C. N. , D. M. D., CLEMENTI, MASSIMO, CLEMENTI, NICOLA, De Marco, D, Di Pietro, A, Gubareva, Lv, M. N. contributed equally to the paper, MANCINI, NICASIO, Mishin, V, Moreno, Gj, Siccardi, Ag, Solforosi, L, Vicenzi, E   +13 more
core   +1 more source

Influenza virus hemagglutinin concentrates in lipid raft microdomains for efficient viral fusion [PDF]

Proceedings of the National Academy of Sciences, 2003
Lipid raft microdomains are enriched in sphingomyelin and cholesterol and function as platforms for signal transduction and as the site of budding of several enveloped viruses, including influenza virus. The influenza virus hemagglutinin (HA) glycoprotein, which mediates both viral-cell attachment and membrane fusion, associates intrinsically with ...
Charles J. Russell, George P. Leser, Makoto Takeda, Robert A. Lamb   +3 more
openaire   +3 more sources

Antibody-Based Strategies to Prevent and Treat Influenza [PDF]

, 2015
Passive immunization using antibodies is a promising alternative to other antiviral treatment options. The potential for seasonal protection arising from a single injection of antibodies is appealing and has been pursued for a number of infectious agents.
Sasisekharan, Ram, Shriver, Zachary, Trevejo, Jose M.   +2 more
core   +1 more source

In the Shadow of Hemagglutinin: A Growing Interest in Influenza Viral Neuraminidase and Its Role as a Vaccine Antigen [PDF]

Viruses, 2014
Despite the availability of vaccine prophylaxis and antiviral therapeutics, the influenza virus continues to have a significant, annual impact on the morbidity and mortality of human beings, highlighting the continued need for research in the field. Current vaccine strategies predominantly focus on raising a humoral response against hemagglutinin (HA)—
Teddy Wohlbold, Florian Krammer
openaire   +4 more sources

Antigenic mapping of an H9N2 avian influenza virus reveals two discrete antigenic sites and a novel mechanism of immune escape [PDF]

, 2015
H9N2 avian influenza virus is a major cause of poultry production loss across Asia leading to the wide use of vaccines. Efficacy of vaccines is often compromised due to the rapid emergence of antigenic variants.
Adamiak, B, Barclay, W, Iqbal, M, James, J, Peacock, T, Reddy, K, Shelton, H   +6 more
core   +1 more source

Inhibition of Influenza A Virus (H1N1) Fusion by Benzenesulfonamide Derivatives Targeting Viral Hemagglutinin

PLoS ONE, 2011
Hemagglutinin (HA) of the influenza virus plays a crucial role in the early stage of the viral life cycle by binding to sialic acid on the surface of host epithelial cells and mediating fusion between virus envelope and endosome membrane for the release of viral genomes into the cytoplasm.
Lei Zhu, Yuhuan Li, Haodong Li, Henry Lu, Rong Zhao, Guozhi Tang, Chichang Lee, Xianfeng Lin, Jim Zhen Wu, Wengang Yang, Li Chen, Shaohua Li, Zongxing Qiu   +12 more
openaire   +5 more sources

Glycans as receptors for influenza pathogenesis [PDF]

, 2010
Influenza A viruses, members of the Orthomyxoviridae family, are responsible for annual seasonal influenza epidemics and occasional global pandemics.
A Chandrasekaran, A Gambaryan, A Gottschalk, A Srinivasan, A Varki, Aarthi Chandrasekaran, Aravind Srinivasan, AS Gambaryan, AS Gambaryan, AS Gambaryan, AS Gambaryan, C Basler, C Traving, CA Bewley, CW Lee, DA Steinhauer, DC Nguyen, DC Wiley, E Klenk, F Zilliken, G Neumann, GK Hirst, GN Rogers, HL Yen, IA Wilson, J Stevens, J Stevens, JC Paulson, JJ Skehel, JK Taubenberger, JM Nicholls, K Kumari, K Shinya, Karthik Viswanathan, LA Perrone, LG Baum, M Bernfield, M Matrosovich, M Matrosovich, M Matrosovich, MB Eisen, MD Jong de, MI Nelson, NM Varki, O Blixt, O Blixt, P Bohm, P Palese, PH Seeberger, R Raman, R Raman, R Sasisekharan, Rahul Raman, Ram Sasisekharan, RJ Connor, RJ Russell, RJ Russell, RL Chen, S Hanson, S Yamada, SJ Gamblin, T Ito, T Kuiken, TH Tran, TM Tumpey, TM Tumpey, TM Tumpey, TM Tumpey, TR Maines, TR Maines, V. Sasisekharan, X Song, Y Ha, Y Ha, Y Suzuki, ZY Yang   +75 more
core   +1 more source

Hemagglutinin–Neuraminidase of Human Parainfluenza 3: Role of the Neuraminidase in the Viral Life Cycle

Virology, 1995
The function of neuraminidase in the life cycle and pathogenesis of human parainfluenza virus type 3 (HPF3) was studied by analyzing a variant of HPF3 that has decreased neuraminidase enzymatic activity. The variant virus is more fusogenic than the wild-type virus during an acute infection.
Richard W. Peluso, Anne Moscona, Kety Huberman   +2 more
openaire   +3 more sources

The ability of pandemic influenza virus hemagglutinins to induce lower respiratory pathology is associated with decreased surfactant protein D binding [PDF]

, 2011
Pandemic influenza viral infections have been associated with viral pneumonia. Chimeric influenza viruses with the hemagglutinin segment of the 1918, 1957, 1968, or 2009 pandemic influenza viruses in the context of a seasonal H1N1 influenza genome were ...
Crouch, Erika C., Dugan, Vivien G., Hartshorn, Kevan L., Jagger, Brett W., Kash, John C., Lau, Yuk-Fai, Qi, Li, Sheng, Zhong-Mei, Taubenberger, Jeffery K.   +8 more
core   +1 more source

Nature Inspired Delivery Vehicles for CRISPR‐Based Genome Editing

Small, EarlyView.
The review highlights nature‐inspired nanocarriers for CRISPR delivery, emphasizing viral vectors, extracellular vesicles, liposomes, and lipid nanoparticles. It discusses their roles in improving specificity, minimizing immunogenicity, and overcoming barriers in genome editing. Recent advancements, challenges, and therapeutic applications are explored,
Elizabeth Maria Clarissa, Mamata Karmacharya, Hyunmin Choi, Sumit Kumar, Yoon‐Kyoung Cho   +4 more
wiley   +1 more source