Results 61 to 70 of about 6,574 (157)

Stalking influenza by vaccination with pre-fusion headless HA mini-stem. [PDF]

, 2016
Inaccuracies in prediction of circulating viral strain genotypes and the possibility of novel reassortants causing a pandemic outbreak necessitate the development of an anti-influenza vaccine with increased breadth of protection and potential for rapid ...
A Schneemann, AH Ellebedy, C Ganesh, CJ Wei, D Corti, D Sharma, DC Ekiert, DC Ekiert, DG Higgins, DJ DiLillo, DT O’Hagan, F Ferrara, F Krammer, F Krammer, G Bommakanti, G Bommakanti, J Stevens, J Sui, JJ Skehel, JJ Skehel, JR Whittle, MB Mazanec, NJ Temperton, PH Goff, RD de Vries, S Guthe, S Jegaskanda, S Khurana, SA Valkenburg, TJ Wohlbold, U Rathore, VV Mallajosyula, VV Mallajosyula, W Gerhard, Y Huang, Y Wu   +35 more
core   +2 more sources

Understanding of endo/lysosomal escape of nanomaterials in biomedical application

Smart Molecules, EarlyView.
This review summarized mainstream mechanisms of endo/lysosomal escape and design strategies of endo/lysosomal escapable nanoparticles in view of surface charge, polarity & hydrophobicity, particle morphology, and lysosomal escape agents. The utilization of endo/lysosomal escapable nanoparticles for vaccine delivery and genetic engineering are ...
Xin Wang, Haoyu Li, Chen Chen, Zhihui Liang   +3 more
wiley   +1 more source

The Spike but Not the Hemagglutinin/Esterase Protein of Bovine Coronavirus Is Necessary and Sufficient for Viral Infection

Virology, 2002
The spike (S) and hemagglutinin/esterase (HE) of bovine coronavirus (BCV) are the two envelope proteins that recognize the same receptor-determinant of 9-O-acetylneuraminic acid on host cells. However, the precise and relative roles of the two proteins in BCV infectivity remain elusive. To unequivocally determine their roles in viral cytopathogenicity,
Xuming Zhang, Rada Popova
openaire   +3 more sources

Inhibition of Influenza A Virus Replication by Compounds Interfering with the Fusogenic Function of the Viral Hemagglutinin [PDF]

Journal of Virology, 1999
ABSTRACT Several compounds that specifically inhibited replication of the H1 and H2 subtypes of influenza virus type A were identified by screening a chemical library for antiviral activity. In single-cycle infections, the compounds inhibited virus-specific protein synthesis when added before or immediately after infection but were ...
Stanley A. Lang, Ramaswamy Nilakantan, Martin Joseph Digrandi, Olga Palant, Bloom Jonathan David, Mary Bradley, Larocque James Paul, Bryan Mark O'hara, Morin John Edward, Yakov Gluzman, Stephen J. Plotch   +10 more
openaire   +3 more sources

Trends of influenza B during the 2010–2016 seasons in 2 regions of north and south Italy: The impact of the vaccine mismatch on influenza immunisation strategy [PDF]

, 2018
Influenza A and B viruses are responsible for respiratory infections, representing globally seasonal threats to human health. The 2 viral types often co-circulate and influenza B plays an important role in the spread of infection.
Alicino C., Ansaldi F., Calamusa G., Canepa P., Colomba G. M. E., Orsi A., Pojero F., Tramuto F., Trucchi C., Vitale F.   +9 more
core   +1 more source

Microneedle delivery systems for vaccines and immunotherapy

Smart Molecules, EarlyView.
This paper reviews the preparation methods and materials of microneedles for drug delivery, summarizes the structures and types of microneedle systems, analyzes the influence of antigens and adjuvants on the efficacy of microneedle vaccines, and reviews the current application status of microneedles in the fields of vaccines and immunotherapy by ...
Haiyao Jia, Jinyuan Liu, Mengqian Shi, Manzar Abbas, Ruirui Xing, Xuehai Yan   +5 more
wiley   +1 more source

Genome-wide analyses reveal a highly conserved Dengue virus envelope peptide which is critical for virus viability and antigenic in humans. [PDF]

, 2016
Targeting regions of proteins that show a high degree of structural conservation has been proposed as a method of developing immunotherapies and vaccines that may bypass the wide genetic variability of RNA viruses.
Bordignon, Juliano, Dos Santos, Paula F, Ferguson, Brian J, Fleith, Renata C, Lo Sarzi, Maria, Lobo, Francisco P, Mansur, Daniel S, Patricio, Daniel O, Pavanelli, Wander R, Rocha, Mariana M, Santos, Claudia ND, Strottmann, Daisy M   +11 more
core   +1 more source

Dimeric DNA Aptamers for the Spike Protein of SARS‐CoV‐2 Derived from a Structured Library with Dual Random Domains

Small Methods, EarlyView.
Dimeric in a single go: A novel DNA aptamer library has been designed to yield dimeric aptamers in a single in vitro selection. Tested against the SARS‐CoV‐2 spike protein, this dual random domain (DRD) library with two 25‐nucleotide random regions and a 20‐nucleotide poly‐thymidine linker produced high‐affinity dimeric aptamers with KD values as low ...
Ryan Amini, Jian Ma, Zijie Zhang, Qing Wang, Jimmy Gu, Leyla Soleymani, Yingfu Li   +6 more
wiley   +1 more source

Oligomerization of bacterially expressed H1N1 recombinant hemagglutinin contributes to protection against viral challenge [PDF]

Scientific Reports, 2018
AbstractVaccination is the most effective intervention to prevent influenza and control the spread of the virus. Alternatives are needed to the traditional egg-based vaccine strategy for a more rapid response to new outbreaks. Two different hemagglutinin (HA) fragments (rHA11-326 and rHA153-269) derived from influenza A virus subtype H1N1 were ...
Kuenstling, Tess E., Sambol, Anthony R., Hinrichs, Steven H., Larson, Marilynn A.   +3 more
openaire   +4 more sources

Organoid Models to Study Human Infectious Diseases

Cell Proliferation, EarlyView.
Our manuscript reviews the role of organoids as models for studying human infectious diseases, highlighting their irreplaceable contributions to drug testing and vaccine development for significant infectious diseases including HIV, ZIKV, SARS‐CoV‐2 and MPXV.
Sijing Zhu, Dan Chen, Xinzhi Yang, Liuliu Yang, Yuling Han   +4 more
wiley   +1 more source