Role of viral hemagglutinin glycosylation in anti-influenza activities of recombinant surfactant protein D [PDF]
Respiratory Research, 2008 Surfactant protein D (SP-D) plays an important role in innate defense against influenza A viruses (IAVs) and other pathogens.We tested antiviral activities of recombinant human SP-D against a panel of IAV strains that vary in glycosylation sites on their hemagglutinin (HA).
Hartshorn, Kevan L +8 more
openaire +4 more sources
Respiratory antiviral immunity and immunobiotics: Beneficial effects on inflammation-coagulation interaction during influenza virus infection [PDF]
, 2016 Influenza virus (IFV) is a major respiratory pathogen of global importance, and the cause of a high degree of morbidity and mortality, especially in high-risk populations such as infants, elderly, and immunocompromised hosts.
Alvarez, Gladis Susana +3 more
core +1 more source
Phylogeographic Dynamics of H9N2 Avian Influenza Viruses in Tunisia
Virus ResearchAvian influenza virus subtype H9N2 is endemic in commercial poultry in Tunisia. This subtype affects poultry and wild birds in Tunisia and poses a potential zoonotic risk.
Imen Larbi +9 more
doaj +1 more source
Hemagglutinin sequence conservation guided stem immunogen design from influenza A H3 subtype [PDF]
, 2015 Seasonal epidemics caused by influenza A (H1 and H3 subtypes) and B viruses are a major global health threat. The traditional, trivalent influenza vaccines have limited efficacy because of rapid antigenic evolution of the circulating viruses.
Citron, Michael +6 more
core +4 more sources
Stimulation of Heterophil Hemagglutinins in Chickens by a Viral Vaccine and Chicken Thyroid Extract [PDF]
Acta Veterinaria Scandinavica, 1973 The formation of heteroag-glutinins against human group O, horse and sheep erythrocytes was studied in groups of chickens injected with various materials. Production of antibodies cross-reacting with some or all of the test cell types was induced both with chicken thyroid extract, with or without adjuvant, and with inactivated infectious bronchitis ...
D, Sharma, J, Tuomi
openaire +2 more sources
Frontiers in ImmunologyBackgroundThe implementation of mRNA vaccines against COVID-19 has successfully validated the safety and efficacy of the platform, while at the same time revealing the potential for their applications against other infectious diseases.
James D. Allen +6 more
doaj +1 more source
Dependence of the energies of fusion on the intermembrane separation: optimal and constrained
, 2007 We calculate the characteristic energies of fusion between planar bilayers as afunction of the distance between them, measured from the hydrophobic/hydrophilic interface of one of the two nearest, cis, leaves to the other.
Lee, J. Y., Schick, M.
core +1 more source
Rapid preparation of mutated influenza hemagglutinins for influenza virus pandemic prevention [PDF]
, 2016 Influenza viruses have periodically caused pandemic due to frequent mutation of viral proteins. Influenza viruses have two major membrane glycoproteins: hemagglutinin (HA) and neuraminidase (NA).
Kuroda, Kouichi +4 more
core +1 more source
Monoclonal antibodies detect different forms of influenza virus hemagglutinin during viral penetration and biosynthesis [PDF]
Journal of Virology, 1985 Monoclonal antibodies specific for the influenza virus A/PR/8/34 hemagglutinin (HA) were used to examine the structure of the HA glycoprotein by immunofluorescence techniques during infection of MDCK cells. One antibody (Y8-10C2), shown previously to detect conformational alterations in the HA coinciding with the acid induction of viral fusion activity,
T, Bächi, W, Gerhard, J W, Yewdell
openaire +2 more sources
A single amino acid substitution in the novel H7N9 influenza A virus NS1 protein increases CPSF30 binding and virulence [PDF]
, 2014 Although an effective interferon antagonist in human and avian cells, the novel H7N9 influenza virus NS1 protein is defective at inhibiting CPSF30. An I106M substitution in H7N9 NS1 can restore CPSF30 binding together with the ability to block host gene ...
Ayllon, Juan +6 more
core +3 more sources