Results 191 to 200 of about 394,042 (312)

Engineering antibodies with cancer‐associated binding sites

BMEMat, EarlyView.
This review describes antibodies that perform direct/indirect roles in cancer treatment by binding to effective targets and discusses how antibodies kill tumors and modulate tumor microenvironment through these targets. The classification of expression systems for antibody production is summarized to guide appropriate selection based on different ...
Yinqi Tian, Yumeng Pan, Yingchun Zhang, Fangling Wang, Zejun Wang   +4 more
wiley   +1 more source

Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities. [PDF]

Stem Cell Res Ther
Liao Y, Octaviani S, Tian Z, Wang SR, Huang C, Huang J.   +5 more
europepmc   +1 more source

Unveiling the complexity of cellular senescence in cancers: From mechanism to therapeutic opportunities

BMEMat, EarlyView.
This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan, Ye Zhu, Zhi Ye, Huayang Zhang, Junxi Wang, Guozhong Yi, Zhiyong Li, Rongyang Xu, Luyao Wang, Zhenzhen Wu, Songtao Qi, Guanglong Huang, Shanqiang Qu   +12 more
wiley   +1 more source

Prenatal Exposure to Chemotherapy Increases the Mutation Burden in Human Neonatal Hematopoietic Stem Cells. [PDF]

Cancer Discov
Struys I, Velázquez C, Ubels J, LeJeune CL, van Roosmalen MJ, Rosendahl Huber AKM, van Leeuwen AJCN, Bossuyt W, Thienpont B, Voet T, Van Calsteren K, Lenaerts L, van Boxtel R, Amant F.   +13 more
europepmc   +1 more source

Deciphering the skeletal interoceptive circuitry to control bone homeostasis

BMEMat, EarlyView.
This review introduces the skeletal interoceptive circuitry, covering the ascending signals from bone tissues to the brain (sensors), the central neural circuits that integrate this information and dispatch commands (CPU), and the descending pathways that regulate bone homeostasis (effectors).
Yefeng Wu, Jiusi Guo, Zhen Chen, Fengwei Zhang, Billy Kwok Chong Chow, Zhuofan Chen, Kelvin Wai‐Kwok Yeung, Wei Qiao   +7 more
wiley   +1 more source

Phase separation participates in the genetic regulation mechanism of hematopoietic stem cells: potential therapeutic methods. [PDF]

Stem Cell Res Ther
Tang X, Wang Y, Xu R.
europepmc   +1 more source

Designing next‐generation immune cell therapies with nanomaterials

BMEMat, EarlyView.
Nanomaterials are transforming immune cellular therapies (ICT) by addressing challenges like tumor accessibility and lengthy manufacturing. This perspective highlights innovations such as magnetic nanoparticles for target identification, lipid nanoparticles for T cell stimulation, and nanoparticle‐mediated gene cytokine delivery. These advances promise
Kangfu Chen, Wenhan Wang, Zongjie Wang
wiley   +1 more source

Cost-Effectiveness of Preemptive Plerixafor Versus Rescue Plerixafor for Mobilization and Collection of Hematopoietic Stem Cells in Patients With Multiple Myeloma and Lymphoma. [PDF]

J Clin Apher
Passos RMA, Marcolino MAZ, Passos JA, Calsavara VF, de Lourdes Martins Perobelli L, Campolina AG, de Almeida-Neto C.   +6 more
europepmc   +1 more source

Aminated graphene nanosheet stimulates the maturation of hiPSCs‐derived cardiomyocytes in vitro and enhances their survival in vivo

BMEMat, EarlyView.
Aminated graphene (G‐NH2) niche matrix plays a pivotal role in precisely manipulating cardiac differentiation and maturation of hiPSCs. The molecular mechanism underlying cardiomyocyte maturation is closely linked to the PDGF‐β signaling pathway. Cardiomyocytes derived from the G‐NH2 matrix exhibit enhanced activity and functionality in vivo.
Yin Xu, Xvdong Wang, Zihao Wang, Qi Chen, Donghui Zhang, Nianguo Dong, Jianglin Wang   +6 more
wiley   +1 more source

Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition. [PDF]

Blood Adv
Williams MJ, Wang X, Bastos HP, Grondys-Kotarba G, Wu Q, Jin S, Johnson C, Mende N, Calderbank E, Wantoch M, Park HJ, Mantica G, Hannah R, Wilson NK, Pask DC, Hamilton TL, Kinston SJ, Asby R, Sneade R, Baxter EJ, Campbell P, Vassiliou GS, Laurenti E, Li J, Göttgens B, Green AR.   +25 more
europepmc   +1 more source