Results 201 to 210 of about 363,743 (307)

Harnessing DNA barcoding to enhance and sustain polyclonality in gene-edited hematopoietic stem cells. [PDF]

Mol Ther Methods Clin Dev
Ojeda-Perez I, Bustos A, Selvaraj S, Fañanas-Baquero S, Alberquilla-Fernandez O, Serrano LJ, Bonafont J, Garcia-Torralba A, Torres-Ruiz R, Rodriguez-Perales S, Lang V, Trigueros C, Mayo-Garcia R, Quintana-Bustamante O, Porteus M, Sánchez-Dominguez R, Segovia JC.   +16 more
europepmc   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Posttransplantation clonal dynamics of hematopoietic stem cells carrying prenatal and early-life <i>DNMT3A</i> mutations. [PDF]

Hemasphere
Derks LLM, Müskens KF, van Roosmalen MJ, de Graaf AO, Epskamp N, Trabut L, Hagelaar R, Jansen JH, Lindemans CA, van Bergen MGJM, van Boxtel R, Belderbos ME.   +11 more
europepmc   +1 more source

Composition‐Aware Cross‐Sectional Integration for Spatial Transcriptomics

Advanced Intelligent Discovery, EarlyView.
Multi‐section spatial transcriptomics demands coherent cell‐type deconvolution, domain detection, and batch correction, yet existing pipelines treat these tasks separately. FUSION unifies them within a composition‐aware latent framework, modeling reads as cell‐type–specific topics and clustering in embedding space.
Qishi Dong, Zijian Huang, Xuanwu Wang, Zhenghui Feng, Wei Liu, Bingding Huang   +5 more
wiley   +1 more source

Sound‐Based Assembly of Magnetically Actuated Soft Robots Toward Enhanced Release of Extracellular Vesicles

Advanced Intelligent Systems, Volume 7, Issue 3, March 2025.
Magnetic soft robots offer promise in biomedicine due to their wireless actuation and rapid response, but current fabrication methods are complex and have limited cellular compatibility. A new, contactless bioassembly strategy using hydrodynamic instabilities is introduced, enabling customizable, centimeter‐scale robots.
Wei Gao, Riccardo Tognato, Micaela Natta, Elena Della Bella, Alessandro Cianciosi, Tiziano Serra   +5 more
wiley   +1 more source

AP2M1 Amplification Orchestrates Notch-Mediated Chemoresistance in Hematopoietic Stem Cells of Acute Myeloid Leukemia Patients. [PDF]

Adv Sci (Weinh)
Lee H, Kim EK, Ju HY, Lee CR, Ahn S, Kim ES, Myung K, Kim WK, Cho SY, Kwon Y, Kim D, Yu Y, Kwon EJ, Kim H, Mun SI, Lim DM, Kim K, Heo HJ, Baek SE, Lee SY, Cho H, Choi EY, Goh TS, Baryawno N, Lee D, Jung KS, Yoo KH, Oh CK, Kim YH.   +28 more
europepmc   +1 more source

Blood signals: from birth to disease and death

, 2014
Bowman, T., Flores-Figueroa, E., King, K., Kokkaliaris, K., Lessard, J., Trompouki, E., Will, B.   +6 more
core   +1 more source

Epigenetic profiling of hematopoietic stem cells from male mice identifies KDR and PU.1 as regulators of aging transcriptome and caloric restriction response. [PDF]

Nat Commun
Zong L, Park B, Tekin-Turhan F, Kuribayashi W, Tanaka-Yano M, Li K, Beerman I.   +6 more
europepmc   +1 more source

Selinexor and Venetoclax Combination in Patients With Relapsed or Refractory Acute Myeloid Leukemia

American Journal of Hematology, EarlyView.
ABSTRACT Preclinical studies showed a synergistic antileukemia activity with combination of selective XPO1 inhibitor selinexor (SEL) and venetoclax (VEN), with potential to overcome VEN resistance by reducing the anti‐apoptotic protein MCL1. In an investigator‐sponsored, open‐label, phase Ib study (NCT03955783), adult patients with relapsed or ...
Somedeb Ball, Farrukh T. Awan, Ben K. Tomlinson, Tess Stopczynski, Melissa A. Fischer, Zhiguo Zhao, Kateryna Fedorov, Ashwin Kishtagari, Sanjay R. Mohan, Gregory D. Ayers, Michael T. Byrne, Michael R. Savona   +11 more
wiley   +1 more source

Correction: The dark side of stemness - the role of hematopoietic stem cells in development of blood malignancies. [PDF]

Front Oncol
Filipek-Gorzała J, Kwiecińska P, Szade A, Szade K.   +3 more
europepmc   +1 more source