SIRT5 desuccinylates and stabilizes RAC2, activating CSF1R‐dependent signaling to drive monocyte differentiation into M0 macrophages and their polarization toward pro‐inflammatory M1 phenotypes in CTX‐induced premature ovarian insufficiency. Inhibiting the SIRT5‐RAC2 axis attenuates inflammation, reduces granulosa cell apoptosis, and preserves ...
Wenjing TanTai +15 more
wiley +1 more source
Normal Hematopoietic Stem Cells in Leukemic Bone Marrow Environment Undergo Morphological Changes Identifiable by Artificial Intelligence. [PDF]
Li D, Li A, DeSouza N, Li S.
europepmc +1 more source
Clinical Relevance Of Large Granular Lymphocyte Expansion Following Allogeneic Hematopoietic Stem Cell Transplantation With HLA Identical Sibling Donors [PDF]
Dong-Hyun Kim +9 more
openalex +1 more source
Single‐Cell Profiling: Any Scale, Any Size, All at Once
Traditional single‐cell technologies are constrained by cellular dimension and throughput scale, in addition to its inability preserve spatial information. With recent innovations, these technologies now allow high throughput, large‐sized cell, and multi‐modal profiling of patient samples, overcoming these limitations.
Denise Goh +4 more
wiley +1 more source
Correction: The dark side of stemness - the role of hematopoietic stem cells in development of blood malignancies. [PDF]
Filipek-Gorzała J +3 more
europepmc +1 more source
The Role of S1PR1 Agonism in Thymus-Dependent T-Cell Regeneration and Graft-vs.-Tumor Activity Following Experimental Allogeneic Hematopoietic Stem Cell Transplantation [PDF]
Madeleine Vollmer, Werner Krenger
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Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li +17 more
wiley +1 more source
BCLAF1 restrains stress responses in hematopoietic stem cells to support expansion and repopulation. [PDF]
Crowley SJ +8 more
europepmc +1 more source
Citation: 'hematopoietic stem cell' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.13201 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms ...
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