Results 221 to 230 of about 1,175,170 (409)

NOX2‐Driven Oxidative Stress Promotes EndMT and Uncouples Angiogenesis–Osteogenesis at the Bone–Implant Interface in Diabetes

Advanced Science, EarlyView.
NOX2‐driven oxidative stress disrupts angiogenesis–osteogenesis coupling at the diabetic bone–implant interface. Pharmacologic inhibition and endothelial‐specific NOX2 knockout restore type‐H endothelium, suppress EndMT, and improve osseointegration.
Zimei Wu, Qiaodan Hou, Yang Liu, Tingting Chen, Kunkun Yang, Luyao Li, Lin Wang   +6 more
wiley   +1 more source

Normal Hematopoietic Stem Cells in Leukemic Bone Marrow Environment Undergo Morphological Changes Identifiable by Artificial Intelligence. [PDF]

Int J Mol Sci
Li D, Li A, DeSouza N, Li S.
europepmc   +1 more source

Single‐Cell Profiling: Any Scale, Any Size, All at Once

Advanced Science, EarlyView.
Traditional single‐cell technologies are constrained by cellular dimension and throughput scale, in addition to its inability preserve spatial information. With recent innovations, these technologies now allow high throughput, large‐sized cell, and multi‐modal profiling of patient samples, overcoming these limitations.
Denise Goh, Felicia Wee, Rachel Elizabeth Ann Fincham, Ruisi Li, Joe Yeong   +4 more
wiley   +1 more source

The Immune Microenvironment in Liver Cancer: From Analysis to Targeting

Advanced Science, EarlyView.
This review explores how smart nanomedicines overcome the immunosuppressive tumor microenvironment in liver cancer. It details targeted delivery strategies and immune reprogramming mechanisms, including remodeling abnormal physiology, modulating metabolism, and inducing immunogenic cell death. The article highlights the paradigm shift toward multimodal
Jiaming Lan, Hao Li, Jian Xue, Yourong Duan, Jin Sun, Meng Niu   +5 more
wiley   +1 more source

Correction: The dark side of stemness - the role of hematopoietic stem cells in development of blood malignancies. [PDF]

Front Oncol
Filipek-Gorzała J, Kwiecińska P, Szade A, Szade K.   +3 more
europepmc   +1 more source

Selection-free genome editing of the sickle mutation in human adult hematopoietic stem/progenitor cells

Science Translational Medicine, 2016
M. DeWitt, W. Magis, Nicolas L. Bray, Tianjiao Wang, Jennifer R. Berman, F. Urbinati, S. Heo, T. Mitros, Denise P. Muñoz, D. Boffelli, D. Kohn, M. Walters, D. Carroll, D. Martin, J. Corn   +14 more
semanticscholar   +1 more source

Artificial Intelligence Revolution in Transcriptomics: From Single Cells to Spatial Atlases

Advanced Science, EarlyView.
Single‐cell RNA sequencing and spatial transcriptomics have unveiled cellular heterogeneity and tissue organization with unprecedented resolution. Artificial intelligence (AI) now plays a pivotal role in interpreting these complex data. This review systematically surveys AI applications across the entire analytic workflow and offers practical guidance ...
Shixin Li, Tianxiang Xiao, Yuanyuan Lan, Chengxiao Wu, Zhouying Li, Rong Liu, Qing Fang, Chao Zhang   +7 more
wiley   +1 more source

Gene-edited hematopoietic stem cells for leukemia and lymphoma treatment: a systematic review of preclinical and translational evidence. [PDF]

Discov Oncol
Nourmohammadi H, Babashahi M, Panji M, Radmehr S.   +3 more
europepmc   +1 more source

[Clinical observation of 12 patients with refractory/relapsed acute myeloid leukemia treated with allogeneic hematopoietic stem cell transplantation containing cladribine regimen].

, 2019
Hao Ai, Yuewen Fu, Y Q Wang, Xudong Wei, Yong-Wen Song   +4 more
openalex   +2 more sources

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, EarlyView.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source