Results 221 to 230 of about 416,052 (359)

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Gene-edited hematopoietic stem cells for leukemia and lymphoma treatment: a systematic review of preclinical and translational evidence. [PDF]

Discov Oncol
Nourmohammadi H, Babashahi M, Panji M, Radmehr S.   +3 more
europepmc   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

A capsular myofibroblastic niche maintains hematopoietic stem cells in the spleen. [PDF]

EMBO J
Mehatre SH, Sanam S, Agrawal H, Hejjaji AV, Kumar AS, Alam MT, Khurana S.   +6 more
europepmc   +1 more source

How Do Donor-Recipient CMV Serostatus and Post-Hematopoietic Stem Cell Transplantation CMV Reactivation Affect Outcomes in Acute Leukemia Patients?

, 2017
Mohammad Vaezi, Amir Kasaeian, Maryam Souri, Faeze Soufiyan, Amir Shokri Boosjin, Seyed Amin Setarehdan, Kamran Alimoghaddam, Ardeshir Ghavamzadeh   +7 more
openalex   +1 more source

Identification of a Force‐Induced Sox9+Acan+ Transitional Subpopulation Linked to FGF2–FGFR2–ERK Signaling in Orthodontic Bone Remodeling

Advanced Science, EarlyView.
Mechanical loading induces a previously unrecognized Sox9+Acan+ transitional mesenchymal cell population in the periodontal ligament that promotes osteoclastogenesis via the FGF2–FGFR2–ERK axis. Targeting this mechanoresponsive stromal population using a localized GelMA@siRNA delivery strategy attenuates pathological osteoclast overactivation and root ...
Miao Tan, Minyu He, Mingrui Zong, Qiya Tang, Yinan Liu, Jiaju Deng, Shun Huang, Xiaoxiao Lei, Jie Li, Lan Huang   +9 more
wiley   +1 more source

Gene therapy supports long-term reconstitution of patient hematopoietic stem cells in deficiency of adenosine deaminase 2. [PDF]

Mol Ther Methods Clin Dev
Rigamonti C, Bulté D, Barzaghi F, Mesa-Nuñez C, Basso-Ricci L, Pettinato E, Visconti C, Degl'Innocenti S, Gazzo F, Benedicenti F, Arévalo S, Quaranta P, Sanvito F, Caorsi R, Schena F, Lupia M, Federici S, Insalaco A, De Benedetti F, Scala S, Miano M, Conti F, Cicalese MP, Montini E, Gattorno M, Dufour C, Aiuti A, Mortellaro A.   +27 more
europepmc   +1 more source

Blood signals: from birth to disease and death

, 2014
Bowman, T., Flores-Figueroa, E., King, K., Kokkaliaris, K., Lessard, J., Trompouki, E., Will, B.   +6 more
core   +1 more source

Direct Extracellular Matrix Modulation Attenuates Intestinal Fibrosis via a Fibronectin‐Targeted Approach

Advanced Science, EarlyView.
Fibronectin regulates the extracellular matrix (ECM)–myofibroblast cycle through three key steps: (1) its secretion and assembly by myofibroblasts (inhibited by pUR4); (2) collagen deposition along its scaffold (inhibited by R1R2); and (3) integrin α5β1‐mediated mechanotransduction (inhibited by ATN161).
Wenlong Ma, Siyu Yang, Tengkai Wang, Di Zhang, Hewei Wu, Shichen Fu, Xiaohan Wan, Lixiang Li, Xiuli Zuo, Yanqing Li, Jiaoyang Lu   +10 more
wiley   +1 more source

Engraftment and persistence of <i>HBB</i> base-edited hematopoietic stem cells in nonhuman primates. [PDF]

Sci Transl Med
Radtke S, Fields E, Swing K, Kanestrom G, Yen JS, Pande D, Enstrom MR, Humbert O, Weiss MJ, Liu DR, Newby GA, Kiem HP.   +11 more
europepmc   +1 more source