Results 221 to 230 of about 363,743 (307)

Remethylation of Dnmt3a−/− hematopoietic cells is associated with partial correction of gene dysregulation and reduced myeloid skewing [PDF]

, 2020
Bangert, Celia V., Brune, Meryl K., Chang, Gue Su, Chen, David Y., Fronick, Catrina, Fulton, Robert S., George, Daniel R., Helton, Nichole M., Hoock, Mieke, Ketkar, Shamika, Leight, Elizabeth R., Ley, Timothy J., Miller, Christopher A., Petti, Allegra A., Ramakrishnan, Sai Mukund, Smith, Amanda M., Spencer, David H., Verdoni, Angela M.   +17 more
core   +1 more source

Research progress on biomarkers of traumatic brain injury

Animal Models and Experimental Medicine, EarlyView.
Traumatic brain injury: From primary insult to secondary neuroinflammation and degeneration. Abstract Traumatic brain injury (TBI) is a common disorder of the nervous system and has become a leading cause of death and disability worldwide, imposing a substantial burden on patients and their social circles. Its main symptoms include dyskinesia, language
Xuting Shen, Si Cheng, Shuyi Chen, Mengyue Wang, Tangying Li, Weicheng Xu, Yifan Zhang, Ping Yuan, Lei Shi   +8 more
wiley   +1 more source

Engraftment and persistence of <i>HBB</i> base-edited hematopoietic stem cells in nonhuman primates. [PDF]

Sci Transl Med
Radtke S, Fields E, Swing K, Kanestrom G, Yen JS, Pande D, Enstrom MR, Humbert O, Weiss MJ, Liu DR, Newby GA, Kiem HP.   +11 more
europepmc   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Nanoengineered 3D culture substrate enables superior persistence and polyclonal engraftment of genetically engineered hematopoietic stem cells.

Cell Stem Cell
Midena F, Alessandrini L, Conci C, Barcella M, Gazzo F, Jacchetti E, Carsana E, Benedicenti F, Vacca R, Della Volpe L, Arévalo S, Giannetti K, Barozzi D, Franchino M, Zonari E, Ferrua F, Farina G, Brombin C, Cugnata F, Fiumara M, Tavella T, Cherubin L, Fraschetta F, Cerullo G, Osellame R, Radrizzani M, Ferrari S, Merelli I, Gentner B, Scielzo C, Brendolan A, Naldini L, Aiuti A, Montini E, Raimondi MT, Di Micco R.   +35 more
europepmc   +1 more source

Gene therapy supports long-term reconstitution of patient hematopoietic stem cells in deficiency of adenosine deaminase 2. [PDF]

Mol Ther Methods Clin Dev
Rigamonti C, Bulté D, Barzaghi F, Mesa-Nuñez C, Basso-Ricci L, Pettinato E, Visconti C, Degl'Innocenti S, Gazzo F, Benedicenti F, Arévalo S, Quaranta P, Sanvito F, Caorsi R, Schena F, Lupia M, Federici S, Insalaco A, De Benedetti F, Scala S, Miano M, Conti F, Cicalese MP, Montini E, Gattorno M, Dufour C, Aiuti A, Mortellaro A.   +27 more
europepmc   +1 more source

G‐CSF for Mobilizing CD34+ Cells in Individuals With SCD: A Word of Caution

American Journal of Hematology, EarlyView.
Akshay Sharma, Allistair Abraham, Monica Bhatia, María Cancio, Sonali Chaudhury, Selim Corbacioglu, Gregory M. T. Guilcher, Ashish O. Gupta, Rabi Hanna, Matthew M. Heeney, Tami John, Lakshmanan Krishnamurti, James L. LaBelle, Hemalatha G. Rangarajan, Shalini Shenoy, Elizabeth Stenger, Crawford Strunk, Courtney D. Fitzhugh   +17 more
wiley   +1 more source

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

The impact of dietary restriction on transcriptional profiles of hematopoietic stem cells in aged female mice. [PDF]

Biogerontology
Yu C, Qiu X, Tao S, Wu Y, He S, Wang Q, Tang D, Wang Y.   +7 more
europepmc   +1 more source

Magnetic Resonance Imaging as a Complementary Diagnostic Tool for Aplastic Anemia

American Journal of Hematology, EarlyView.
Jeanette Walter, Peter Isfort, Susanne Isfort, Jens Panse, Katharina Lindemann‐Docter, Tim H. Brümmendorf, Fabian Beier   +6 more
wiley   +1 more source