Results 271 to 280 of about 416,052 (359)

Mitochondrial quality control in hematopoietic stem cells: mechanisms, implications, and therapeutic opportunities. [PDF]

Stem Cell Res Ther
Liao Y, Octaviani S, Tian Z, Wang SR, Huang C, Huang J.   +5 more
europepmc   +1 more source

A Murine Bispecific Antibody Efficiently Redirects T Cells Against Calr Mutated Stem Cells In Vivo

American Journal of Hematology, EarlyView.
ABSTRACT Calreticulin (CALR) mutations are prevalent in 20%–30% of patients with BCR::ABL1‐negative myeloproliferative neoplasms (MPN). Mutant calreticulin (mutCALR), presented by the thrombopoietin receptor (MPL, also known as TPOR or CD110) on the surface of the disease‐initiating MPN progenitors, represents an ideal target for curative ...
Shengen Xiong, Tamara Wais, Cecilia Varga, Christina Schueller, Sarada Achyutuni, Robert Kralovics   +5 more
wiley   +1 more source

EMP1 safeguards hematopoietic stem cells by suppressing sphingolipid metabolism and alleviating endoplasmic reticulum stress. [PDF]

Nat Commun
Li L, Lei Y, Li Y, Xie Y, Hui P, Zang X, Wu W, Wu F, Fan J, Wang J, Chen J, Chen Z, Hou Y.   +12 more
europepmc   +1 more source

Targeted depletion of dysfunctional hematopoietic stem cells mitigates myeloid-biased differentiation in aged mice. [PDF]

Cell Discov
Ren X, Wang Y, Zhang Y.
europepmc   +1 more source

New approaches to treating chronic obstructive pulmonary disease with Colla corii asini

Animal Models and Experimental Medicine, EarlyView.
Colla corii asini improves chronic obstructive pulmonary disease (COPD) treatment through anti‐inflammatory, antioxidant, immune‐modulatory, and lung‐nourishing effects, addressing current therapeutic challenges via multitarget mechanisms. Abstract Chronic obstructive pulmonary disease (COPD) is one of the leading causes of death and disability ...
Wenchao Zhang, Siman Sun, Xiaoyu Fan, Jiuming He, Qing Li, Hongtao Jin   +5 more
wiley   +1 more source

Targeting RhoA activity rejuvenates aged hematopoietic stem cells

Florian MC, Mejia-Ramirez E, Picazo PI, Walter B, Montserrat-Vazquez S, Affuso F, Wieser S, Pezzano F, Reymond L, Castillo-Robles J, Matteini F, Mularoni L, Maciá D, Raya Á, Ruprecht V, Zheng Y, Petrone P.   +16 more
europepmc   +1 more source

Imbalanced TGFβ signalling and autophagy drive erythroid priming of hematopoietic stem cells in β-thalassemia. [PDF]

Nat Commun
Lidonnici MR, Chianella G, Mende N, Bastos HP, Barcella M, Merelli I, Storto M, Romeo V, Tiboni F, Scaramuzza S, Rossi C, Raggi L, Aprile A, Crippa S, Iskander D, Roberts I, Karamiditris A, Keith J, Lechauve C, Weiss MJ, Wilson NK, Göttgens B, Bernardo ME, Ciceri F, Aiuti A, Marktel S, Laurenti E, Ferrari G.   +27 more
europepmc   +1 more source

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source

The influence of high-fat diet and energy-restricted diet on hematopoietic stem cells: mechanisms and implications. [PDF]

Front Immunol
Chen Z, Ang H, Li J, Yu M, Chen X, Wang L.   +5 more
europepmc   +1 more source

Preparedness, Uncertainty, and Distress Among Family Caregivers in the Care of Patients Undergoing Hematopoietic Stem Cell Transplantation

Ali Karimi-Rozveh, Elahe Nasrollahi Bishe, Tayeb Mohammadi, Mohammad Vaezi, Leila Sayadi   +4 more
openalex   +2 more sources