Results 291 to 300 of about 1,162,311 (403)

Pharmacogenomics in clinical practice: Biomarker information in Brazilian drug labels

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
This review examines the PGx annotations in package inserts (bulas in Brazilian Portuguese) approved by ANVISA, the Brazilian Health Regulatory Agency, for 19 gene–drug pairs with strong or moderate recommendations for initial dosing alteration in the CPIC (Clinical Pharmacogenetic Implementation Consortion) guidelines and PGx testing required or ...
Guilherme Suarez‐Kurtz
wiley   +1 more source

Targeting RhoA activity rejuvenates aged hematopoietic stem cells

open access: yes
Florian MC   +16 more
europepmc   +1 more source

Stem cell factor induces proliferation and differentiation of highly enriched murine hematopoietic cells.

open access: green, 1991
Giovanni Migliaccio   +6 more
openalex   +1 more source

Regulation of glycolysis by Pdk functions as a metabolic checkpoint for cell cycle quiescence in hematopoietic stem cells.

open access: yesCell Stem Cell, 2013
K. Takubo   +12 more
semanticscholar   +1 more source

Revisiting Clonal Evolution Through the Light of Retrotransposons

open access: yesBioEssays, EarlyView.
We propose integrating retrotransposons into the clonal evolution model of cancer. Retrotransposons can modulate cancer cell fitness, potentially influencing clonal dynamics. They might also induce lineage violations via cell fusion or horizontal transfer.
Anaïs Lamoureux   +3 more
wiley   +1 more source

Maintenance of hematopoietic stem cells by tyrosine-unphosphorylated STAT5 and JAK inhibition. [PDF]

open access: yesBlood Adv
Williams MJ   +25 more
europepmc   +1 more source

Optimizing biophysical properties of cellular niches to enhance stem cell‐derived extracellular vesicle function in musculoskeletal regeneration

open access: yesBMEMat, EarlyView.
Extracellular vesicles (EVs) derived from stem cells show promise for applications in regenerative medicine, but their scalability and yield remain challenges. This review explores the approaches for biophysical modulations within cell niches on EV properties, discusses the current clinical application of EVs, and provides an outlook on the existing ...
Yang Xu   +9 more
wiley   +1 more source

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