Results 101 to 110 of about 428,654 (353)

Substantially Altered Local and Systemic Immunity in Ischemia‐Free Versus Conventional Liver Transplantation

Advanced Science, EarlyView.
This study investigates how ischemia‐free liver transplantation (IFLT) shapes both local and systemic immune responses compared with conventional liver transplantation (CLT). Our findings demonstrate that IFLT confers significant immunological protection by attenuating the STAT3‐HIF‐1α axis and enhancing the Heme‐HMOX1 pathway, two regulatory networks ...
Tao Luo, Shuai He, Shirui Chen, Dongmei Ye, Shibo Zhang, Di Liu, Dawei Zou, Linhe Wang, Huadi Chen, Jinghong Xu, Huanjie Liu, Ruiting Liu, Xi Tan, Yitong Wang, Jiayi Zeng, Runbing Mo, Yuexin Li, Yuyi Zhang, Tanyiyang Ruan, Tielong Wang, Zehua Jia, Yu Jia, Tongdi Fang, Yimou Lin, Xiaorui Liu, Yunhua Tang, Maogen Chen, Qiang Zhao, Anbin Hu, Weiqiang Ju, Yi Ma, Dongping Wang, Xiaofeng Zhu, Schlegel Andrea, Yuan Zhai, Kwan Man, Tullius G. Stefan, Yifang Gao, Jinxin Bei, Xiaoshun He, Zhiyong Guo   +40 more
wiley   +1 more source

A conserved two-component system senses intracellular iron levels and regulates redox balance in Mycobacterium spp.

Microbiology Spectrum
For bacteria, an intricate coordination between sensing and regulating iron levels and managing oxidative stress is required as their levels are tightly interlinked.
Rahul Yadav, Deepak Kumar Saini
doaj   +1 more source

An investigation into the feasibility of myoglobin-based single-electron transistors

, 2012
Myoglobin single-electron transistors were investigated using nanometer- gap platinum electrodes fabricated by electromigration at cryogenic temperatures. Apomyoglobin (myoglobin without heme group) was used as a reference.
Bendall D S, David Lederman, Debin Li, Dong J, Garrett R H, Hayashi T, Li D, Park J, Peter M Gannett, Spiro T G   +9 more
core   +1 more source

Structure of a bacterial cell surface decaheme electron conduit [PDF]

, 2011
Some bacterial species are able to utilize extracellular mineral forms of iron and manganese as respiratory electron acceptors. In Shewanella oneidensis this involves decaheme cytochromes that are located on the bacterial cell surface at the termini of ...
A. Hall, A. J. Gates, A. S. Beliaev, Adams, Bucking, C. L. Reardon, Collaborative Computational Project Number, D. J. Richardson, Einsle, Emsley, Field, Firer-Sherwood, G. F. White, Hartshorne, Igarashi, J. Bradley, J. K. Fredrickson, J. M. Zachara, J. N. Butt, Johs, L. Shi, Lies, M. J. Edwards, M. J. Marshall, McCoy, McLean, N. J. Watmough, Porollo, Ries, Ruebush, Sheldrick, Shi, Shi, T. A. Clarke, Z. Wang   +34 more
core   +3 more sources

Induction of NLRP3 Inflammasome Activation by Heme in Human Endothelial Cells

Oxidative Medicine and Cellular Longevity, 2018
Hemolytic or hemorrhagic episodes are often associated with inflammation even when infectious agents are absent suggesting that red blood cells (RBCs) release damage-associated molecular patterns (DAMPs). DAMPs activate immune and nonimmune cells through
J. Erdei, A. Tóth, E. Balogh, B. Nyakundi, Emese Bányai, B. Ryffel, G. Paragh, M. Cordero, V. Jeney   +8 more
semanticscholar   +1 more source

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, EarlyView.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

Construction of a Plasmid-Free Escherichia coli Strain with Enhanced Heme Supply to Produce Active Hemoglobins

Metabolites
Background: Heme is an important cofactor and plays crucial roles in the correct folding of hemoproteins. The synthesis of heme can be enhanced by the plasmid-based expression of heme biosynthetic genes.
Zihan Zhang, Baodong Hu, Jingwen Zhou, Jianghua Li, Jian Chen, Guocheng Du, Xinrui Zhao   +6 more
doaj   +1 more source

Heme-Derived Metabolic Signals Dictate Immune Responses

Frontiers in Immunology, 2020
Heme is one of the most abundant molecules in the body acting as the functional core of hemoglobin/myoglobin involved in the O2/CO2 carrying in the blood and tissues, redox enzymes and cytochromes in mitochondria.
Giacomo Canesin, Seyed M. Hejazi, Kenneth D. Swanson, Barbara Wegiel   +3 more
doaj   +1 more source

Resonance Raman Spectroscopy Reveals that Substrate Structure Selectively Impacts the Heme-Bound Diatomic Ligands of CYP17 [PDF]

, 2013
An important function of steroidogenic cytochromes P450 is the transformation of cholesterol to produce androgens, estrogens, and the corticosteroids.
Gregory, Michael C., Kincaid, James R., Mak, Piotr J., Sligar, Stephen G.   +3 more
core   +2 more sources

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source