Results 21 to 30 of about 414,309 (352)
Heme‐hemopexin: A ‘Chronosteric’ heme‐protein [PDF]
IUBMB Life, 2007 AbstractHemopexin (HPX) serves as scavenger and transporter of toxic plasma heme to the liver. HPX is formed by two four‐bladed β‐propeller domains, resembling two thick disks that lock together at a 90° angle. The heme is bound between the two β‐propeller domains in a pocket formed by the interdomain linker peptide.
ASCENZI P, FASANO, MAURO
openaire +4 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2022 Significance Heme availability in the cell enables the proper folding and function of enzymes, which carry heme as a cofactor. Using genome-scale modeling, we identified metabolic fluxes and genes that limit heme production.
O. P. Ishchuk +6 more
semanticscholar +1 more source
Microbiology Spectrum, 2022 Heme is both an essential cofactor and an abundant source of nutritional iron for the human pathogen Mycobacterium tuberculosis. While heme is required for M. tuberculosis survival and virulence, it is also potentially cytotoxic. Since M.
Rebecca K. Donegan +11 more
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Relación existente entre la ratio 2D:4D y la composición corporal en adolescentes de Extremadura
E-Motion, 2020 Introducción: La ratio 2D:4D es el cociente entre la longitud del dedo índice y anular de la mano, asociada al balance entre andrógenos y estrógenos, durante el desarrollo embrionario. Una baja proporción 2D:4D, refleja niveles más altos de testosterona
Maria Mendoza Muñoz +3 more
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The Worst Things in Life are Free: The Role of Free Heme in Sickle Cell Disease
Frontiers in Immunology, 2021 Hemolysis is a pathological feature of several diseases of diverse etiology such as hereditary anemias, malaria, and sepsis. A major complication of hemolysis involves the release of large quantities of hemoglobin into the blood circulation and the ...
Oluwabukola T Gbotosho +2 more
semanticscholar +1 more source
Biomolecules, 2022 In patients, endometrial hyperplasia (EH) is often accompanied by abnormal uterine bleeding (AUB), which is prone to release large amounts of heme. However, the role of excess heme in the migration and infiltration of immune cells in EH complicated by ...
Lu-Yu Ruan +8 more
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Influence of Body Composition on Physical Fitness in Adolescents
Medicina, 2020 Background and objectives: Childhood obesity is one of the main public health issues facing advanced societies. The Spanish population presents 28.6% overweight or obese adolescents, and Extremadura, 22.3%.
María Mendoza-Muñoz +5 more
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Hsp90 in Human Diseases: Molecular Mechanisms to Therapeutic Approaches
Cells, 2022 The maturation of hemeprotein dictates that they incorporate heme and become active, but knowledge of this essential cellular process remains incomplete. Studies on chaperon Hsp90 has revealed that it drives functional heme maturation of inducible nitric
Mamta P. Sumi, Arnab Ghosh
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Frontiers in Microbiology, 2021 Iron is an important micronutrient that is required by bacteria to proliferate and to cause disease. Many bacterial pathogens forage iron from human hemoglobin (Hb) during infections, which contains this metal within heme (iron–protoporphyrin IX ...
Ken Ellis-Guardiola +6 more
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, 2020 The novel coronavirus pneumonia (COVID-19) is an infectious acute respiratory caused by the novel coronavirus. The virus is the positive-strand RNA one with high homology to bat coronavirus.
Wenzhong Liu, Hualan Li
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