Results 71 to 80 of about 153,280 (319)
Advanced Synthesis &Catalysis, Accepted Article.Unspecific Peroxygenases have been the subject of a lot of research in the recent past as they offer opportunities for green hydroxylation reactions using hydrogen peroxide (H2O2) as donor. A striking problem of UPOs is their low stability against their own co‐substrate H2O2.
Simon Last +6 more
wiley +1 more source
Nrf2 Plays a Protective Role Against Intravascular Hemolysis-Mediated Acute Kidney Injury
Frontiers in Pharmacology, 2019 Massive intravascular hemolysis is associated with acute kidney injury (AKI). Nuclear factor erythroid-2-related factor 2 (Nrf2) plays a central role in the defense against oxidative stress by activating the expression of antioxidant proteins.
Alfonso Rubio-Navarro +24 more
doaj +1 more source
Second order estimates for convex solutions of degenerate $k$-Hessian equations [PDF]
arXiv, 2022 The $C^{1,1}$ estimate of the Dirichlet problem for degenerate $k$-Hessian equations with non-homogenous boundary conditions is an open problem, if the right hand side function $f$ is only assumed to satisfy $f^{1/(k-1)} \in C^{1,1}$. In this paper, we solve this problem for convex solutions defined in the strictly convex bounded domain.
arxiv
Influence of heme c attachment on heme conformation and potential [PDF]
JBIC Journal of Biological Inorganic Chemistry, 2018 Heme c is characterized by its covalent attachment to a polypeptide. The attachment is typically to a CXXCH motif in which the two Cys form thioether bonds with the heme, "X" can be any amino acid other than Cys, and the His serves as a heme axial ligand.
Jesse G. Kleingardner +5 more
openaire +3 more sources
Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation
Advanced Science, EarlyView.At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao +14 more
wiley +1 more source
Frontiers in Cellular and Infection Microbiology, 2018 Malaria is a serious disease and was responsible for 429,000 deaths in 2015. Acute lung injury/acute respiratory distress syndrome (ALI/ARDS) is one of the main clinical complications of severe malaria; it is characterized by a high mortality rate and ...
Marcelo L. M. Pereira +2 more
doaj +1 more source
Curvature estimates for a class of Hessian type equations [PDF]
arXiv, 2020 In this paper, we establish the curvature estimates for a class of Hessian type equations. Some applications are also discussed.
arxiv
The Pogorelov estimates for degenerate curvature equations [PDF]
arXiv, 2022 We establish the Pogorelov type estimates for degenerate prescribed k-curvature equations as well as k-Hessian equations. Furthermore,we investigate the interior C1,1 regularity of the solutions for Dirichlet problems. These techniques also enable us to improve the existence theorem for an asymptotic Plateau type problem in hyperbolic space.
arxiv
Heme and the Endothelium [PDF]
Journal of Biological Chemistry, 1998 We studied the effects of nitric oxide (NO) on the control of excess cellular heme and release of catalytically active iron. Endothelial cells (ECs) exposed to hemin followed by a NO donor have a ferritin content that is 16% that of cells exposed to hemin alone.
William E. Antholine +6 more
openaire +3 more sources
Advanced Science, EarlyView.This study explores the structural heterogeneity and evolutionary adaptations of heteromultimeric bacterioferritins. Hetero‐Bfrs, evolved from either a homo‐Bfr or Ftn by gene duplications, differ from homo‐Bfrs substantially in the mechanisms underpinning iron oxidation and reduction despite high similarity in overall structure.
Yingxi Li +5 more
wiley +1 more source