Results 191 to 200 of about 94,120 (279)

Emerging Role of Ferroptosis in Diabetes and Associated Complications: When Metabolic Dysregulation Meets Cell Death

Cell Proliferation, Volume 59, Issue 5, May 2026.
This study identifies ferroptosis as a key driver of diabetes and its complications via iron metabolism and lipid peroxidation, elucidates organelle interactions underlying cell vulnerability, and provides insights for targeted therapies against metabolic disorders.
Zheng Wang, Ying Zhang, Yue Xu, Mengyuan Yang, Yuan Wei, Yuan Li, Tongyue Yang, Xu Wang, Chaona Yang, Qi Feng, Guolan Xing   +10 more
wiley   +1 more source

Heme Oxygenase-1 Expression as a Prognostic Marker in Early-Stage HCC Undergoing Resection or Liver Transplantation. [PDF]

Life (Basel)
Cadar R, Vasilescu AM, Trofin AM, Nastase AG, Zabara M, Muzica C, Ursulescu CL, Danciu M, Pascu A, Buzincu I, Ciobanu D, Victor I, Lupascu CD.   +12 more
europepmc   +1 more source

Identification of Common Blood Metabolic Derangements Using Magnetic Resonance Signatures of the Pancreas and Liver

Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4162-4175, May 2026.
ABSTRACT Aim To investigate whether common disturbances of glucose and lipid metabolism can be automatically identified from magnetic resonance signatures of the pancreas and liver. Methods In this proof‐of‐principle study, 100 individuals with a history of pancreatitis—a relatively homogeneous population at risk for metabolic derangements—underwent ...
Wandia Kimita, Juyeon Ko, Loren Skudder‐Hill, Xiatiguli Shamaitijiang, Yutong Liu, Maxim S. Petrov   +5 more
wiley   +1 more source

The promoter T-413A variant and elevated enzyme levels of heme oxygenase-1 associated with an increased risk of polycystic ovarian syndrome. [PDF]

Front Endocrinol (Lausanne)
Wang Q, Liang J, Liu Q, Liu H, Bai H, Huang W, Fan P.   +6 more
europepmc   +1 more source

Whole Blood Transcriptomic Analysis of Sickle Cell Trait

European Journal of Haematology, Volume 116, Issue 5, Page 535-544, May 2026.
ABSTRACT Sickle cell trait (SCT) is the heterozygous carrier state for the HBB missense variant which causes sickle cell disease (SCD). SCT has been associated with increased risk of venous thromboembolism and chronic kidney disease as well as alterations in clinical laboratory parameters. To investigate differential gene expression in SCT, we used RNA
Mari Johnson, Yanwei Cai, Ana Gabriela Vasconcelos, Peter Orchard, Paul L. Auer, Guillaume Lettre, Jia Wen, Nora Franceschini, Charles Kooperberg, Wei Sun, Li Hsu, Laura M. Raffield, Alex P. Reiner   +12 more
wiley   +1 more source

THC and CBD Induce Heme Oxygenase-1-Dependent Cell Death and Trigger Mitochondrial Dysfunction in Human Melanoma and Cutaneous Squamous Cell Carcinoma Cells. [PDF]

Antioxidants (Basel)
Thamm E, Wittig F, Hamann B, Wendt F, Emmert S, Frank M, Hinz B.   +6 more
europepmc   +1 more source

The Secretome Derived From Serum‐Free Media of SHED‐MSCs Can Modulate THP‐1‐Derived Macrophage Cells

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Although culturing cells in serum‐free or low‐serum media may lead to reduced cell proliferation, it is crucial to minimise the presence of foreign proteins and other impurities that could compromise the validity of experimental findings on immunomodulation.
Azadeh Mohammad‐Hasani, Saeed Mohammadi, Mohsen Saeidi, Ali Fallah, Ayyoob Khosravi   +4 more
wiley   +1 more source

Heme oxygenase-1 leads to cisplatin resistance in nasopharyngeal carcinoma by reducing oxidative stress and ferroptosis. [PDF]

Cancer Cell Int
Cheng Z, Huang L, Zhang Y, Yue K, Jia S, Fang Z, Lin Z.   +6 more
europepmc   +1 more source

Single‐Cell Analysis of Preeclamptic Cord Blood Mononuclear Cells Revealed Activation of Heme‐Associated Signalling Pathways

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT Preeclampsia is a severe gestational complication whose molecular pathogenesis remains poorly understood despite extensive research. It is now recognized that both maternal and fetal cells contribute to disease progression. Notably, single‐cell RNA sequencing of cord blood cells from preeclamptic pregnancies has not been previously ...
Polina Vishnyakova, Evgeny Karpulevich, Victoria Karyagina, Elena Gantsova, Yulia Trofimovich, Viktoriia Kiseleva, Miroslava Chirkova, Tatiana Gerashchenko, Anastasiya Lokhonina, Kamilla Muminova, Zulfiya Khodzhaeva, Evgeny Denisov, Andrey Elchaninov, Timur Fatkhudinov, Gennady Sukhikh   +14 more
wiley   +1 more source

Modulating nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 in liver-brain axis disorders. [PDF]

World J Psychiatry
Zhang YM, Zhang ZG.
europepmc   +1 more source