The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 2, February 2026.ABSTRACT Sepsis‐associated liver injury (SALI) plays a major role in aggravating disease progression and worsening prognosis in patients with sepsis. Macrophage polarization is a key factor in the modulation of SALI progression. Recent studies have shown that human breast milk‐derived exosomes (HBM‐Exos) regulate processes involved in macrophage ...
Zhao‐Bin Yang +3 more
wiley +1 more source
On the Therapeutic Potential of Heme Oxygenase-1 and Its Metabolites. [PDF]
Antioxidants (Basel)Stec DE.
europepmc +1 more source
Bone Metastasis: Molecular Mechanisms, Clinical Management, and Therapeutic Targets
MedComm, Volume 7, Issue 2, -Not available-.This figure emphasizes current understanding of the regulatory networks, approach of diagnose, available preclinical models and clinical management of bone metastasis. to guide future therapeutic development. A deep understanding of these aspects enables the prevention of bone metastasis and the implementation of effective therapeutic strategies ...
Jingyuan Wen +5 more
wiley +1 more source
Selective Inhibition of Vascular Smooth Muscle Cell Function by COVID-19 Antiviral Drugs: Impact of Heme Oxygenase-1. [PDF]
Antioxidants (Basel)Peyton KJ, Durante GL, Durante W.
europepmc +1 more source
Cryo‐EM reveals an ensemble of cytochrome P450 reductase conformations in solution
Protein Science, Volume 35, Issue 2, February 2026.Abstract The eukaryotic electron transport system, mediated by cytochrome P450 reductase (CPR), plays a crucial role in driving myriads of reactions involved in the biosynthesis of physiologically active compounds (such as sterols, steroids, vitamins, and natural products), as well as in the metabolism of drugs, toxins, and carcinogens.
Galina I. Lepesheva +2 more
wiley +1 more source
Nuclear factor erythroid 2-related factor 2/heme oxygenase-1 activation by nattokinase reduces pro-inflammatory and matrix-degrading mediators in human gingival fibroblasts. [PDF]
J Dent SciLi YL +8 more
europepmc +1 more source
CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.ABSTRACT Bilirubin is a breakdown product of erythrocytes and plays a crucial role in elimination of heme‐containing proteins. After its synthesis in the reticuloendothelial system, unconjugated bilirubin is released into plasma and taken up into the liver.
Ahenk Zeynep Sayin, Lars Kuepfer
wiley +1 more source
Adipose-derived mesenchymal stromal cell secretome protects against kidney injury through induction of heme oxygenase 1 upregulation <i>in vitro</i>. [PDF]
World J NephrolJafar H +7 more
europepmc +1 more source
Effect of Denervation on Skeletal Muscle Mitochondria in Heterozygous mtDNA Mutator Mice
FASEB BioAdvances, Volume 8, Issue 2, February 2026.Denervation induces mitochondrial dysfunction and oxidative stress in skeletal muscle. In PolG(+/mut) mice, denervation led to reduced mitochondrial DNA copy number and a pronounced upregulation of the antioxidant enzyme catalase, despite comparable levels of muscle atrophy, mitochondrial content, and mitochondrial dynamics‐related proteins compared to
Takanaga Shirai +6 more
wiley +1 more source
NADPH-Independent Fluorescent Probe for Live-Cell Imaging of Heme Oxygenase-1. [PDF]
ACS SensLi L +7 more
europepmc +1 more source