ABSTRACT Cardiovascular diseases (CVD) remain the leading global cause of morbidity and mortality, driven in part by dysregulated redox homeostasis and chronic inflammation. Superoxide dismutase (SOD), a key enzymatic defence against reactive oxygen species (ROS), plays a central role in maintaining cardiovascular integrity through regulation of ...
Danial Khayatan +10 more
wiley +1 more source
[Retracted] <i>In vivo</i> and <i>in vitro</i> effects of heme oxygenase-1 silencing on the survival of acute myelocytic leukemia-M2 cells. [PDF]
Wei S +5 more
europepmc +1 more source
Heme oxygenase 1 confers gilteritinib resistance in FLT3-ITD acute myeloid leukemia in a STAT6-dependent manner. [PDF]
Zhang T +11 more
europepmc +1 more source
Mechanistic Review of Topical Therapies Targeting Dermal Fibroblasts in Skin Aging and Rejuvenation
ABSTRACT Background Skin aging appears in multiple forms, including wrinkles, sagging, scarring, atrophy, and photoaging. Although each phenotype has distinct biological features, all are rooted in dermal fibroblast dysfunction. This review examines the molecular pathways underlying these conditions and evaluates topical interventions designed to ...
Seyedeh Melika Akaberi +2 more
wiley +1 more source
Gastrodin plays a protective role in alleviating hepatic ischemia reperfusion injury by regulating heme oxygenase-1 expression. [PDF]
He SS +6 more
europepmc +1 more source
Neuregulin‐1 Mitigates Kidney Injury in Humanized Sickle Cell Mice
Compared with untreated sickle cell (HbSS) mice, neuregulin‐1 (NRG‐1) treatment reduced plasma heme, lactate dehydrogenase, and pro‐inflammatory cytokines while increasing the proportion of circulating F‐cells. NRG‐1 improved urinary biomarkers of kidney health, decreasing cystatin C and NGAL levels and increased renal repair markers clusterin and ...
William K. Agbozo +12 more
wiley +1 more source
Heme oxygenase 1 (HO-1) is a drug target for reversing cisplatin resistance in non-small cell lung cancer. [PDF]
Mei J +14 more
europepmc +1 more source
Transcutaneous auricular vagus nerve stimulation improves emotional and cognitive functions in post-traumatic stress disorder rats through anti-inflammation, neuroprotection, and modulation of the hippocampal nuclear factor erythroid 2-related factor 2-heme oxygenase-1-glutathione peroxidase 4 pathway. [PDF]
Yanfeng Z +8 more
europepmc +1 more source

