Results 221 to 230 of about 73,522 (298)

Oxidative Stress and DNA Epigenetic Modifications in Cancer: Mechanisms and Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Reactive oxygen species (ROS) modulate DNA methyltransferases (DNMTs), ten‐eleven translocation family proteins (TETs) and their cofactors, reshaping 5‐methylcytosine (5mC)/5‐hydroxymethylcytosine (5hmC)/5‐formylcytosine (5fC) landscapes and gene expression in cancer cells. In turn, epigenetic control of antioxidant and metabolic pathways feeds back on
Xishan Yang, Qitai Chen, YuJie Yu, Yi Zang, Rujia Zheng, Zhe Zhang, Shuaijun Lu, Li Zhou   +7 more
wiley   +1 more source

Estradiol and Raloxifene Protect Ovariectomized Mice from Acute Kidney Injury via G Protein-Coupled Estrogen Receptor-Mediated Nuclear Factor Erythroid 2-Related Factor 2/Heme Oxygenase-1 Activation. [PDF]

Int J Mol Sci
Wang Y, Song Y, Dai J, Zhang X, Zhao L, Mao Y, Ding M.   +6 more
europepmc   +1 more source

Oxidative Stress in the Tumor Immune Microenvironment: Mechanisms and Therapeutic Perspectives

MedComm – Oncology, Volume 5, Issue 2, June 2026.
Oxidative stress is involved in several key processes in cancer, including redox regulation, DNA damage, post‐translational modifications, transcriptional regulation, epigenetic modifications, metabolic reprogramming, cell death, and immune modulation. These mechanisms collectively influence tumor progression, immune evasion, and therapeutic responses,
Zhen Wang, Bowen Li, Pan Tang, Fanchen Yan, Shuxin Wang, Guiying Leng, Panduo Dawa, Yuansi Chen, Yihan Guo, Pan Yang, Yi Li, Siyu Liu, Erdan Dong, Siyuan Qin, Zhoufeng Wang   +14 more
wiley   +1 more source

Selective Inhibition of Vascular Smooth Muscle Cell Function by COVID-19 Antiviral Drugs: Impact of Heme Oxygenase-1. [PDF]

Antioxidants (Basel)
Peyton KJ, Durante GL, Durante W.
europepmc   +1 more source

Current Status of Kidney Xenotransplantation in Basic Research

Organ Medicine, Volume 3, Issue 2, Page 87-101, June 2026.
Kidney xenotransplantation is a potential solution to the organ shortage for end‐stage kidney disease. This review systematically elaborates on the application advances of donor pig gene editing technologies, the molecular mechanisms and regulatory strategies of xenogeneic immune rejection, and the optimization approaches of immune compatibility ...
Yu Luo, Bingzhuo Liu, Weijie Lai
wiley   +1 more source

Phytotherapeutic Regulation of Matrix Metalloproteinases in Diabetic Foot Ulcer: Molecular Mechanisms and Wound Healing Perspectives

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
Chronic inflammation in diabetic foot ulcers elevates MMP activity and suppresses TIMP and growth factor signaling, impairing tissue repair. Phytochemicals modulate NF‐κB/MAPK pathways and enhance Nrf2–TIMP expression, restoring MMP/TIMP balance, promoting collagen deposition, angiogenesis, and re‐epithelialization, leading to effective wound healing ...
Vishnu Priyan Elaiyaraja, Eswara Rajagopal, Subhikssha Babu, Balaji Sadhasivam   +3 more
wiley   +1 more source

NADPH-Independent Fluorescent Probe for Live-Cell Imaging of Heme Oxygenase-1. [PDF]

ACS Sens
Li L, Lu X, He Q, Shu C, Walter ERH, Wang L, Long NJ, Jiang L.   +7 more
europepmc   +1 more source

Kidney Stone, Nutritional Perceptions and Impact of Tea on Stone Formation

Phytochemicals in Food and Medicine, Volume 1, Issue 2, June 2026.
ABSTRACT The significant financial burden that urinary stone disease places on healthcare systems is only anticipated to increase over time. It is becoming more common over the globe. It is an increasing urinary condition that impacts around 12% of the global population, and environmental variables appear to be a key contributor.
Munir Ahmed, Danish Kamal, Umber Mubeen, Sakhawat Riaz, Amber Tehseen, Muhammad Mazahir   +5 more
wiley   +1 more source

Adipose-derived mesenchymal stromal cell secretome protects against kidney injury through induction of heme oxygenase 1 upregulation <i>in vitro</i>. [PDF]

World J Nephrol
Jafar H, Ababneh NA, Alhattab D, Alatoom RM, Zalloum S, Salah B, Alhawari H, Awidi A.   +7 more
europepmc   +1 more source

Precision environmental medicine: Integrated multi‐exposure transcriptomics for shared molecular networks in COPD pathogenesis in response to environmental exposure

Precision Medical Sciences, Volume 15, Issue 2, Page 147-159, June 2026.
This integrated systems biology study of 2847 exposure‐related genes identifies a conserved 647‐gene core and CYP1B1 hub across cigarette smoke, ozone, and PM2.5. Three key pathways converge, enabling computational repurposing of 15 drug candidates (e.g., NRF2 activators) for environmentally induced COPD.
Fakher Rahim, Gürler Akpinar, Kenesh Dzhusupov   +2 more
wiley   +1 more source