Results 231 to 240 of about 73,522 (298)

Nuclear factor erythroid 2-related factor 2/heme oxygenase-1 activation by nattokinase reduces pro-inflammatory and matrix-degrading mediators in human gingival fibroblasts. [PDF]

J Dent Sci
Li YL, Wu YC, Tseng CF, Wang YL, Li SY, Tien Vo TT, Chen YL, Shih YT, Lee IT.   +8 more
europepmc   +1 more source

Kaempferol Improves Alzheimer's Disease by Inhibiting Neuronal Ferroptosis via Activating GPX4/AKR1C3 Signaling Pathway

Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.
ABSTRACT Kaempferol has been shown to be beneficial in the treatment of Alzheimer's disease (AD) in animal models. However, the action mechanism remains unclear. AKR1B1 has been identified as a target of kaempferol, initially suggested by the Therapeutic Target Database, DrugBank, and PubChem, and subsequently confirmed through experimental validation.
Le Li, Manying Yang, Jiale Tao, Yonghong Zhao, Na Zhao, Shiguo Sun   +5 more
wiley   +1 more source

Protective effect of snail secretion filtrate in an in vitro model of mastitis

Veterinary Record Open, Volume 13, Issue 1, June 2026.
Abstract Background Bovine mastitis is inflammation of the mammary gland mainly caused by bacterial infections, with relevant economic costs and implications related to antibiotic resistance. In light of the increasing demand for sustainable therapies, this study evaluated the anti‐inflammatory and antioxidant effects of snail secretion filtrate (SSF ...
Gianluca Antonio Franco, Ylenia Marino, Rosalia Crupi, Davide di Paola, Salvatore Cuzzocrea, Enrico Gugliandolo   +5 more
wiley   +1 more source

[Expression of Concern] PI3K/Akt signaling pathway‑induced heme oxygenase‑1 upregulation mediates the adaptive cytoprotection of hydrogen peroxide preconditioning against oxidative injury in PC12 cells. [PDF]

Int J Mol Med
Mo L, Yang C, Gu M, Zheng D, Lin L, Wang X, Lan A, Hu F, Feng J.   +8 more
europepmc   +1 more source

The Mechanism of NLRP3 Inflammasome Activation and Its Roles in Chronic Rhinosinusitis

World Journal of Otorhinolaryngology - Head and Neck Surgery, Volume 12, Issue 3, Page 362-373, June 2026.
ABSTRACT NLRP3 (NLR family pyrin domain containing 3) is one of the crucial receptors in pathogen recognition receptor (PRR) families which can recognize the pathogen‐associated molecular patterns (PAMPs) and the damage‐associated molecular patterns (DAMPs), thus triggering innate immune response. After NLRP3 activation, it recruits the adaptor protein
Dong‐Lin Li, Yue Li, Yan‐Jie Jiang, Ge‐Hua Zhang, Li‐Hong Chang   +4 more
wiley   +1 more source

Protective Effects of Ellagic Acid Against Arsenic-Induced Hepatotoxicity in Male Wistar Rats: Impact of Heme Oxygenase-1 Upregulation. [PDF]

Food Sci Nutr
Alkully T, El-Refaei MF, Abdallah EAA.
europepmc   +1 more source

Transcriptional Modulation of the Nrf2 Antioxidant Pathway and Tight Junctions by a Plant Sterol Food Supplement in an Intestinal Inflammation Coculture Model

Journal of Food Science, Volume 91, Issue 6, June 2026.
ABSTRACT There is growing evidence supporting the anti‐inflammatory activity of plant sterols (PS) in preclinical models of intestinal inflammation. However, the underlying mechanisms driving these beneficial effects remain incompletely understood. This study investigates the transcriptional modulatory activity of a PS food supplement (PS‐FS) on genes ...
Mussa Makran, Ilenia Concetta Giardina, Guadalupe Garcia‐Llatas, Alessandro Attanzio, Antonio Cilla   +4 more
wiley   +1 more source

Severity of Repetitive Mild Traumatic Brain Injury Depends on Microglial Heme Oxygenase-1 and Carbon Monoxide. [PDF]

Eur J Neurosci
Kaiser S, Fritsch A, Jakob L, Schallner N.   +3 more
europepmc   +1 more source

Kineochelins—A New Group of Siderophores From an Antarctic Bacterium

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
Genome‐guided analysis of an Antarctic Actinokineospora strain led to the discovery of kineochelins, a new group of siderophores involved in iron sequestration and microbial competition. Kineochelin production inhibits co‐occurring bacteria and clinically relevant yeasts, highlighting Antarctic microorganisms as promising sources of bioactive natural ...
Stanislava Kralova, Peter Spacek, Johannes Gafriller, Matej Bezdicek, Viktoria Medvedcova, Joana Séneca, Jay Osvatic, Ulrike Grienke, Thomas Rattei, Olga N. Sekurova, Sergey B. Zotchev, Martin Zehl, Alexander Loy   +12 more
wiley   +1 more source

Morin hydrate protects against cisplatin-induced testicular toxicity by modulating ferroptosis and steroidogenesis genes' expression and upregulating Nrf2/Heme oxygenase-1. [PDF]

Sci Rep
Mahran Y, Badr AM, Aloyouni S, Alkahtani MM, Sarawi WS, Ali R, Alsultan D, Almufadhili S, Almasud DH, Hasan IH.   +9 more
europepmc   +1 more source