Results 261 to 270 of about 73,522 (298)

Pharmacologic Induction of Heme Oxygenase-1

Antioxidants & Redox Signaling, 2007
Heme oxygenase-1 (HO-1) is a cytoprotective protein whose expression is consistently associated with therapeutic benefits in a number of pathologic conditions such as atherosclerotic vascular disease and inflammation. Although the expression of HO-1 in most tissues is low, a large number of clinical and experimental pharmacologic compounds have been ...
Cheng, Li, Parastu, Hossieny, Ben J, Wu, Abdelqader, Qawasmeh, Konstanze, Beck, Roland, Stocker   +5 more
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Heme oxygenase-1: unleashing the protective properties of heme

Trends in Immunology, 2003
Heme oxygenase (HO)-1 catabolizes heme into three products: carbon monoxide (CO), biliverdin (which is rapidly converted to bilirubin) and free iron (which leads to the induction of ferritin, an iron-binding protein). HO-1 serves as a "protective" gene by virtue of the anti-inflammatory, anti-apoptotic and anti-proliferative actions of one or more of ...
Leo E, Otterbein, Miguel P, Soares, Kenichiro, Yamashita, Fritz H, Bach   +3 more
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Heme oxygenase-1 in organ transplantation

Frontiers in Bioscience, 2007
Cells have a plethora of defense mechanisms that are activated upon exposure to oxidative stress. These aim at limiting the deleterious effects of oxidative stress and re-establishing homeostasis. In the particular context of organ transplantation, these defense mechanisms contribute to sustain graft survival via at least two interrelated mechanisms ...
Miguel P, Soares, Fritz H, Bach
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Heme oxygenase-1 and chronic hypoxia

Respiratory Physiology & Neurobiology, 2012
A myriad of changes are necessary to adapt to chronic hypoxemia. Key among these changes increases in arterial oxygen carrying capacity, ventilation and sympathetic activity. This requires the induction of several gene products many of which are regulated by the activity of HIF-1α, including HO-1.
Judith A, Neubauer, Jag, Sunderram
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Heme oxygenase-1 and heme oxygenase-2 expression in bruises

Forensic Science, Medicine, and Pathology, 2015
The first step in catabolism of hemoglobin in a bruise is performed by the enzyme heme oxygenase, which produces biliverdin that is then reduced to bilirubin. The development of yellow coloration in bruises can be attributed to local accumulation of degradation products of hemoglobin, including bilirubin, but it is not clear why there is a delay before
Neil E I, Langlois, Kelly, Olds, Claire, Ross, Roger W, Byard   +3 more
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Heme Oxygenase-1 and Transplantation Tolerance

Human Immunology, 2006
Tolerance is the ultimate goal of transplantation: the lack of any need for immunosuppression with long-term survival of the transplanted tissue and a full immunological response to all antigens other than those on the transplant. In honor of my dear friend and colleague, Prof. Dr. Jon van Rood, I summarize here our work in this area making use of heme
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Heme Oxygenase-1 Localization in the Rat Nephron

Nephron, 2002
<i>Background/Aims:</i> Renal tubules undergo oxidative injury in various nephropathies. It is unknown whether tubular cells possess mechanisms to attenuate this form of injury. Heme oxygenase-1 (HO-1), the rate-limiting enzyme in heme catabolism, may provide such a mechanism by reducing levels of free heme, a prooxidant molecule, and by ...
Michelle, Shepard, Prasad, Dhulipala, Sunit, Kabaria, Nader G, Abraham, Elias A, Lianos   +4 more
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Induction of the Heme Oxygenase-1 Gene by Metalloporphyrins

Archives of Biochemistry and Biophysics, 2000
Induction of expression of heme oxygenase-1 (HO-1) has been studied in primary cultures of chick embryo liver cells and in the LMH line of avian hepatoma cells. Cells were transiently transfected with selected constructs containing portions of the 5'-untranslated (promoter) region of the HO-1 gene linked to luciferase as reporter gene.
Y, Shan, J, Pepe, T H, Lu, K K, Elbirt, R W, Lambrecht, H L, Bonkovsky   +5 more
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Heme Oxygenase-1 and Transplantation

2004
The discovery of nitric oxide (NO) in 1987 unraveled the novel concept that an endogenous production of a gaseous substance such as NO can impart diverse and critical functional effects on a wide spectrum of biological and pathological processes. These investigations have led to numerous fruitful discoveries, enhancing our understanding of many disease
Patty J. Lee, Ruiping Song, Augustine M. K. Choi   +2 more
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Heme oxygenase 1

AfCS-Nature Molecule Pages, 2009
Barbara Wegiel, Leo Otterbein
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