Results 141 to 150 of about 85,853 (215)

Structural Engineering of Sonosensitive Nanohybrids by Active Vanadium Species toward Collapse of Multi‐Antioxidant Defenses and Boosted Therapy of Triple‐Negative Breast Cancer

Small Structures, Volume 6, Issue 6, June 2025.
A sonosensitive nanohybrid with defect structures is constructed through in situ etching deposition of vanadyl phosphate onto porphyrin metal–organic frameworks (MOFs), in which defects induce narrower bandgap and serve as charge traps for enhancing singlet oxygen generation under ultrasound irradiation. Additionally, released vanadium species overcome
Tingting Zhang, Jing Zhu, Yunyun Wu, Daqing Xia, Xiyue Xie, Lin Li, Zhenqiang Wang, Kaiyong Cai, Jixi Zhang   +8 more
wiley   +1 more source

Malaria parasites require a divergent heme oxygenase for apicoplast gene expression and biogenesis. [PDF]

Elife
Blackwell AM, Jami-Alahmadi Y, Nasamu AS, Kudo S, Senoo A, Slam C, Tsumoto K, Wohlschlegel JA, Manuel Martinez Caaveiro J, Goldberg DE, Sigala PA.   +10 more
europepmc   +1 more source

Integrated Analysis of Gene Expression, Protein Synthesis, and Epigenetic Modifications in Alcanivorax borkumensis SK2 Under Iron Limitation

Environmental Microbiology Reports, Volume 17, Issue 3, June 2025.
Summarised transcriptomics, methylomics, and proteomics data plotted to circular maps using Circos software. Meanings of circles and histograms on the plots are explained in the figure legend. ABSTRACT This study aimed to understand the genetic and molecular mechanisms enabling Alcanivorax borkumensis SK2, a hydrocarbonoclastic marine bacterium, to ...
Francesco Smedile, Renata Denaro, Francesca Crisafi, Domenico Giosa, Giuseppe D'Auria, Manuel Ferrer, Riccardo Rosselli, Martin S. Staege, Michail M. Yakimov, Laura Giuliano, Oleg N. Reva   +10 more
wiley   +1 more source

Gastrodin plays a protective role in alleviating hepatic ischemia reperfusion injury by regulating heme oxygenase-1 expression. [PDF]

Braz J Med Biol Res
He SS, Huang HF, Shi SQ, Zhao JJ, Yuan B, Ji X, Zhang HB.   +6 more
europepmc   +1 more source

The Potential Ability of Betulinic Acid to Prevent Experimentally Induced Acute Pancreatitis in Rats

Basic &Clinical Pharmacology &Toxicology, Volume 136, Issue 6, June 2025.
ABSTRACT Acute pancreatitis (AP) is a serious pancreatic inflammatory disease that results in pancreatic enzyme activation and autodegradation. Betulinic acid (BA), a pentacyclic triterpene of natural origin that was isolated from several plants, has anti‐inflammatory, immunomodulatory and antioxidant effects that can help with AP.
Guler Yenice, Seckin Ozkanlar, Ismail Bolat, Serkan Yildirim   +3 more
wiley   +1 more source

Gromomycins: An Unprecedented Class of Triterpene Antibiotics Produced by a Novel Biosynthetic Pathway

Angewandte Chemie, Volume 137, Issue 22, May 26, 2025.
Gromomycins represent a novel class of pentacyclic triterpene antibiotics with a unique biosynthetic pathway independent of the squalene route. These compounds exhibit potent activity against drug‐resistant Gram‐positive pathogens, including MRSA, and their unprecedented cyclization mechanism provides new insight into bacterial triterpene biosynthesis.
Stepan Tistechok, Dmytro Bratiichuk, Hilda Sucipto, Nils Gummerlich, Marc Stierhof, Oleksandr Gromyko, Franziska Fries, Victor Fedorenko, Rolf Müller, Josef Zapp, Maksym Myronovskyi, Andriy Luzhetskyy   +11 more
wiley   +2 more sources

Correction: Atorvastatin inhibits Lipopolysaccharide (LPS)-induced vascular inflammation to protect endothelium by inducing Heme Oxygenase-1 (HO-1) expression. [PDF]

PLoS One
Luo J, Zhu Q, Huang K, Wen X, Peng Y, Wei G, Chen G.   +6 more
europepmc   +1 more source

Omaveloxolone Suppresses Cell Growth and Causes Cell Cycle Arrest by Downregulating CDC20 Expression in Glioblastoma Cells Both In Vitro and In Vivo

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Omaveloxolone is a synthetic oleanane triterpene with considerable antitumor activity. It induces human glioblastoma (GBM) cell death in vitro and in vivo, but the underlying mechanism remains to be determined. In this study, GBM cell lines (GBM8401 and U‐87 MG cells) were exposed to different concentrations of omaveloxolone (0, 600, 800 and ...
Kuan‐Ting Lee, Yi‐Chiang Hsu, Ann‐Shung Lieu, Chih‐Lung Lin, Tai‐Hsin Tsai   +4 more
wiley   +1 more source

Navigating heme pathways: the breach of heme oxygenase and hemin in breast cancer. [PDF]

Mol Cell Biochem
Consoli V, Sorrenti V, Gulisano M, Spampinato M, Vanella L.   +4 more
europepmc   +1 more source

ChnagG Plays the Role of 5‐Salicylate Hydroxylase in the Gentisic Acid Pathway of Salicylic Acid Metabolism in Cochliobolus heterostrophus

Molecular Plant Pathology, Volume 26, Issue 6, June 2025.
The ChnagG gene in Cochliobolus heterostrophus encodes 5‐salicylate hydroxylase, converting salicylic acid (SA) to gentisic acid, enhancing pathogenicity and suppressing plant SA signalling‐mediated defences during infection. ABSTRACT Salicylic acid (SA) plays a crucial role in the defence strategies of plants against fungal pathogens.
Yadi Xu, He Wei, Haixiao Li, Fanli Zeng, Ning Liu, Zhiyan Cao, Jingao Dong   +6 more
wiley   +1 more source