Results 21 to 30 of about 133,631 (206)

Pangenome Analysis of the Plant Pathogen Pseudomonas syringae Reveals Unique Natural Products for Niche Adaptation

open access: yesAngewandte Chemie, EarlyView.
A pangenome analysis of the plant pathogen Pseudomonas syringae reveals two novel natural product families that facilitate niche adaptation. Comprehensive genomic and chemical analyses uncover unique biosynthetic gene clusters linked to host specificity and environmental fitness.
Shuaibing Zhang   +7 more
wiley   +2 more sources

A Diffusion-Based Approach to Geminate Recombination of Heme Proteins with Small Ligands [PDF]

open access: yes, 2002
A model of postphotodissociative monomolecular (geminate) recombination of heme proteins with small ligands (NO, O2 or CO) is represented. The non-exponential decay with time for the probability to find a heme in unbound state is interpreted in terms of diffusion-like migration of ligabs physics/0212040 and between protein cavities.
arxiv   +1 more source

The Dirichlet problem for a class of prescribed curvature equations [PDF]

open access: yesarXiv, 2022
In this paper, we consider the Dirichlet problem for a class of prescribed curvature equations. Both degenerate and non-degenerate cases are considered. The existence of the $C^{1,1}$ regular graphic hypersurfaces with prescribing a class of curvatures and constant boundary is proved for the degenerate case.
arxiv  

Heme oxygenase inhibition in cancers: possible tools and targets

open access: yesContemporary oncology, 2018
Heme oxygenase-1 (HO-1, encoded by HMOX1) through degradation of pro-oxidant heme into carbon monoxide (CO), ferrous ions (Fe2+) and biliverdin, exhibits cytoprotective, anti-apoptotic and anti-inflammatory properties. All of these potentially beneficial
P. Podkalicka   +4 more
semanticscholar   +1 more source

Punica granatum peel supplementation attenuates cognitive deficits and brain injury in rat by targeting the Nrf2‐HO‐1 pathway

open access: yesFood Science &Nutrition, Volume 11, Issue 1, Page 168-180, January 2023., 2023
The hydro‐ethanolic extract of P. granatum peel was standardized. ;The extract increased superoxide dismutase activity and thiol content, while reduced function of AchE and peroxidation of lipid in the scopolamine‐injured rat’s brain. ;P. granatum may attenuate scopolamine injury through targeting nuclear factor‐E2‐related factor 2 pathway ; Abstract ...
Mahsan Akbarian   +5 more
wiley   +1 more source

Emerging concepts in cancer therapy: Mechanisms of resistance

open access: yes, 2022
Cancer Reports, Volume 5, Issue 12, December 2022.
Seema Gupta   +2 more
wiley   +1 more source

Linalool attenuated ischemic injury in PC12 cells through inhibition of caspase‐3 and caspase‐9 during apoptosis

open access: yesFood Science &Nutrition, Volume 11, Issue 1, Page 249-260, January 2023., 2023
This study indicated, for the first time, that (±) linalool and its enantiomer, (R)‐(‐) linalool protected PC12 cells against injury induced by oxygen and glucose deprivation/reoxygenation (OGD/R) via the mitigation of oxidative stress and the downregulation of Bax/Bcl‐2, caspase‐3 and caspase‐9, resulting in decreased apoptotic cell death.
Azar Hosseini   +5 more
wiley   +1 more source

Heme, Heme Oxygenase, and Endoplasmic Reticulum Stress—A New Insight into the Pathophysiology of Vascular Diseases

open access: yesInternational Journal of Molecular Sciences, 2019
The prevalence of vascular disorders continues to rise worldwide. Parallel with that, new pathophysiological pathways have been discovered, providing possible remedies for prevention and therapy in vascular diseases.
T. Gáll, G. Balla, J. Balla
semanticscholar   +1 more source

Feruloyl oligosaccharides, isolated from bacterial fermented wheat bran, exhibit antioxidant effects in IPEC‐J2 cells and zebrafish model

open access: yesFood Science &Nutrition, Volume 11, Issue 1, Page 295-306, January 2023., 2023
An excess of reactive oxygen species (ROS) can cause cell damage, and an accumulation of damage leads to cellular dysfunction resulting in a variety of diseases including abnormal aging, cancer, diabetes, and inflammation. In this study, feruloyl oligosaccharides (FOs) were obtained by solid‐state fermentation using wheat bran, and antioxidant activity
Qiuyan Chen   +8 more
wiley   +1 more source

Danshensu attenuated lipopolysaccharide‐induced LX‐2 and T6 cells activation through regulation of ferroptosis

open access: yesFood Science &Nutrition, Volume 11, Issue 1, Page 344-349, January 2023., 2023
Danshensu (Dan) attenuates lipopolysaccharide‐induced hepatic stellate cells activation via decreasing expression of collagen І, connective tissue growth factor, glutathione peroxidase 4, cystine/glutamate antiporter xCT, and lipocalin‐2. However, Dan increases lipid reactive oxygen species accumulation.
Changting Wang   +3 more
wiley   +1 more source

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