Results 61 to 70 of about 85,853 (215)
Food Frontiers, EarlyView.Alfalfa flavonoids (AF) protected against Salmonella‐induced colitis by reducing inflammation and oxidative stress. AF inhibited the TLR4/IκB/NF‐κB/COX‐2 pathway and NLRP3 inflammasome, lowering pro‐inflammatory cytokines, while activating Keap1‐Nrf2 to boost antioxidants (e.g., HO‐1, NQO1, SOD, GPx), decreasing ROS‐driven oxidative stress.
Xiaoli Qin +11 more
wiley +1 more source
Carnitine metabolism to trimethylamine by an unusual Rieske-type oxygenase from human microbiota [PDF]
, 2014 Dietary intake of L-carnitine can promote cardiovascular diseases in humans through microbial production of trimethylamine (TMA) and its subsequent oxidation to trimethylamine N-oxide (TMAO) by hepatic flavin-containing monooxygenases.
Bugg, Tim +6 more
core +1 more source
Heme oxygenase-1 and cardiovascular disease.
Histology and histopathology, 2006 Heme oxygenase (HO)-1 is the inducible isoform of the first and rate-controlling enzyme of heme degradation. HO-1 is up-regulated by a host of oxidative stress stimuli and has potent cytoprotective and anti-inflammatory functions via decreasing tissue levels of the prooxidant heme along with production of bilirubin and the signaling gas carbon monoxide.
Immenschuh, S., Schröder, H.
openaire +4 more sources
Food Safety and Health, EarlyView.This review aims to collect and identify cereals, legumes, and vegetables mostly consumed in the Abruzzo region from 2020 till now, pointing attention to their biological effects. ABSTRACT The Abruzzo region boasts a wide range of typical food products including cereals, legumes, and vegetables. In this context, they take part in the Mediterranean diet,
Giulia Gentile +3 more
wiley +1 more source
Global Challenges, EarlyView.This study explores how gradual ascent rates reduce acute pulmonary injury in rats exposed to high‐altitude hypoxia by activating autophagy and suppressing oxidative stress and inflammation. Results show that controlled ascent effectively mitigates such injury, highlighting its potential as a preventive strategy.
Kairui Huang +4 more
wiley +1 more source
Relationship between NOX4 level and angiotensin II signaling in Gitelman's syndrome. Implications with hypertension [PDF]
, 2015 Recent evidence showed that endogenous nicotinamide adenine dinucleotide phosphate-oxidase 4 (NOX4) may exert a protective role on the cardiovascular system inducing vasodilation, reduction of blood pressure, and anti-proliferative actions.
Calò, Lorenzo A +5 more
core
Gene Therapy for Cardiovascular Disease [PDF]
, 2003 The last decade has seen substantial advances in the development of gene therapy strategies and vector technology for the treatment of a diverse number of diseases, with a view to translating the successes observed in animal models into the clinic ...
Baker, Andrew H. +3 more
core +4 more sources
Dry Eye Disease: Oxidative Stress on Ocular Surface and Cutting‐Edge Antioxidants
Global Challenges, EarlyView.This review has systematically evaluated the oxidative damage of cornea, tear film, lacrimal gland, conjunctiva and meibomian gland for dry eye, and concluded the antioxidants that are either commercially available or in the research phase. GQDs: Graphene quantum dots; LF: lactoferrin; ROS: Reactive oxygen species; SOD: Superoxide dismutase; tFNA ...
Rong Hu +3 more
wiley +1 more source
Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer’s disease [PDF]
, 2019 Alzheimer’s disease currently lacks treatment options that effectively reverse the biological/anatomical pathology and cognitive deficits associated with the disease.
Burris, Thomas P +9 more
core +3 more sources
Progress in heme oxygenase research [PDF]
Archives of Biochemistry and Biophysics, 2020 Surh, Young-Joon +4 more
openaire +4 more sources