Results 171 to 180 of about 213,829 (198)
Regulatory interplay between nitric oxide and heme in redox signaling and inflammation. [PDF]
Redox BiolPradhan P +3 more
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Trafficking of Heme and Porphyrins in Metazoa [PDF]
Chemical Reviews, 2009 A half century ago, Max Perutz and John Kendrew determined the crystal structure of two heme-containing proteins – hemoglobin and myoglobin, respectively 1,2. These landmark discoveries created the foundation for a detailed biochemical understanding of how protein structure influences and affects its ability to bind and carry oxygen. Perutz and Kendrew
Iqbal Hamza
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Iron and Porphyrin Trafficking in Heme Biogenesis [PDF]
Journal of Biological Chemistry, 2010 Iron is an essential element for diverse biological functions. In mammals, the majority of iron is enclosed within a single prosthetic group: heme. In metazoans, heme is synthesized via a highly conserved and coordinated pathway within the mitochondria.
Barry H Paw, Caiyong Chen, Iqbal Hamza
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One Ring to Rule Them All: Trafficking of Heme and Heme Synthesis Intermediates in the Metazoans
Biochimica Et Biophysica Acta - Molecular Cell Research, 2012 The appearance of heme, an organic ring surrounding an iron atom, in evolution forever changed the efficiency with which organisms were able to generate energy, utilize gasses and catalyze numerous reactions. Because of this, heme has become a near ubiquitous compound among living organisms.
Iqbal Hamza, Harry A. Dailey
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Heme Dynamics and Trafficking Factors Revealed by Genetically Encoded Fluorescent Heme Sensors [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Significance All heme-dependent functions require the mobilization of labile heme (LH), of which there is little understanding of its nature and dynamics. To probe LH pools, we developed genetically encoded fluorescent heme sensors and deployed them in the unicellular eukaryote Saccharomyces ...
Xiaojing Yuan, Iqbal Hamza, Amit R Reddi
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Heme sensing and trafficking in fungi
Fungal Biology Reviews, 2023Fungal pathogens cause life-threatening diseases in humans, and the increasing prevalence of these diseases emphasizes the need for new targets for therapeutic intervention. Nutrient acquisition during infection is a promising target, and recent studies highlight the contributions of endomembrane trafficking, mitochondria, and vacuoles in the sensing ...
Peng Xue +5 more
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An Intercellular Heme-Trafficking Protein Delivers Maternal Heme to the Embryo During Development in C. Elegans [PDF]
Cell, 2011 Extracellular free heme can intercalate into membranes and promote damage to cellular macromolecules. Thus it is likely that specific intercellular pathways exist for the directed transport, trafficking, and delivery of heme to cellular destinations, although none have been found to date.
Caiyong Chen +2 more
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One Ring to Bring Them All and in the Darkness Bind Them: The Trafficking of Heme Without Deliverers
Biochimica Et Biophysica Acta - Molecular Cell Research, 2021 Heme, as a hydrophobic iron-containing organic ring, is lipid soluble and can interact with biological membranes. The very same properties of heme that nature exploits to support life also renders heme potentially cytotoxic. In order to utilize heme, while also mitigating its toxicity, cells are challenged to tightly control the concentration and ...
Ian Chambers, Iqbal Hamza, Amit R Reddi
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Heme Requirement and Intracellular Trafficking in Trypanosoma cruzi Epimastigotes
Biochemical and Biophysical Research Communications, 2007Epimastigotes multiplies in the insect midgut by taking up nutrients present in the blood meal including heme bound to hemoglobin of red blood cell. During blood meal digestion by vector proteases in the posterior midgut, hemoglobin is clipped off into amino acids, peptides, and free heme.
Pedro L Oliveira, M G P Coelho, A Michel
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