Results 181 to 190 of about 213,829 (198)

Heme biosynthesis and trafficking

Free Radical Biology and Medicine, 2018
Heme is an essential cofactor involved in a plethora of vital functions. Heme is required to be in most subcellular compartments, but the way, in which it is transported from the mitochondria - its site of synthesis - to those compartments is poorly understood.
Jonathan Dietz, Oleh Khalimonchuk, Iryna Bohovych, Amit Reddi, Amy Medlock, Osiris Martinez-Guzman   +5 more
openaire   +1 more source

Heme Trafficking and the Importance of Handling Nature’s Most Versatile Cofactor

Chemical Reviews
Heme is one of the most versatile cofactors in nature from its role in oxygen transport and sensing, bioenergetics, and enzyme catalysis and is therefore an ideal regulatory molecule in responding to the redox status of the cell. However, due to both its redox reactivity and hydrophobicity, heme requires tight regulation at the level of its synthesis ...
Angela Wilks
exaly   +3 more sources

Histidine Residues Are Important for Preserving the Structure and Heme Binding to the C. Elegans HRG-3 Heme-Trafficking Protein

Journal of Biological Inorganic Chemistry, 2015
C. elegans is a heme auxotroph that requires environmental heme for sustenance. As such, worms utilize HRG-3, a small heme-trafficking protein, to traffic heme from the intestine to extra-intestinal tissues and embryos. However, how HRG-3 binds and delivers heme remains unknown.
Sharon Ruthstein, Iqbal Hamza, Ortal Marciano   +2 more
exaly   +3 more sources

Identification of Two Heme-Binding Sites in the Cytoplasmic Heme-Trafficking Protein PhuS from Pseudomonas aeruginosa and Their Relevance to Function

Biochemistry, 2007
PhuS is a cytoplasmic, 39 kDa heme-binding protein from Pseudomonas aeruginosa. It has previously been shown to transfer heme to its cognate heme oxygenase. It is expressed from the phu operon, which encodes a group of proteins known to actively internalize and transport heme from host organisms. This study combines the spectral resolution of resonance
Darci R, Block, Gudrun S, Lukat-Rodgers, Kenton R, Rodgers, Angela, Wilks, Mehul N, Bhakta, Ila B, Lansky   +5 more
openaire   +2 more sources

Biosynthesis and Trafficking of Heme o and Heme a: New Structural Insights and Their Implications for Reaction Mechanisms and Prenylated Heme Transfer

Critical Reviews in Biochemistry and Molecular Biology, 2021
Michael Feig, Lim Heo, Eric L Hegg
exaly  

67 Eukaryotic Heme Trafficking

2011
Scott Severance, Caiyong Chen, Iqbal Hamza   +2 more
openaire   +1 more source

Porphyrin and Heme Trafficking in Metazoans

2013
Iqbal Hamza, Harry A. Dailey
openaire   +1 more source

Biophysical Perspectives on the Acquisition, Transport, and Trafficking of Heme in Bacteria

2013
Kenton R. Rodgers, Gudrun S. Lukat-Rodgers   +1 more
openaire   +1 more source

Safe Coordinated Trafficking of Heme and Iron With Copper Maintain Cell Homeostasis: Modules From the Hemopexin System

BioMetals, 2019
Ann Smith
exaly  

Handling Heme: The Mechanisms Underlying the Movement of Heme Within and Between Cells

Free Radical Biology and Medicine, 2019
Courtney M Moore, Amit R Reddi
exaly