Results 71 to 80 of about 213,829 (198)
Visualizing mitochondrial heme flow through GAPDH in living cells and its regulation by NO
Redox BiologyIron protoporphyrin IX (heme) is a redox-active cofactor that is bound in mammalian cells by GAPDH and allocated by a process influenced by physiologic levels of NO.
Pranjal Biswas +6 more
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Heme Oxygenase-1: A Critical Link between Iron Metabolism, Erythropoiesis, and Development
Advances in Hematology, 2011 The first mature cells to arise in the developing mammalian embryo belong to the erythroid lineage. This highlights the immediacy of the need for red blood cells during embryogenesis and for survival.
Stuart T. Fraser +3 more
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The FEBS Journal, EarlyView.In Neurospora crassa, a cytosolic GH18 endo‐β‐n‐acetylglucosaminidase (ENGase) functions as an active deglycosylating enzyme. Deletion of this severely alters tolerance to multiple stress conditions and causes extensive transcriptomic reprogramming, including upregulation of a GH20 exo‐β‐n‐acetylhexosaminidase under ER stress, indicating that N. crassa
Anastasios Samaras +3 more
wiley +1 more source
, 2020 Heme is an important protein cofactor and signaling molecule that plays diverse roles in biological systems. The hydrophobicity and cytotoxicity of heme necessitates that it is transported and trafficked in a regulated manner.
Saini, Arushi
core
Mitochondrial-nuclear heme trafficking is regulated by GTPases that control mitochondrial dynamics [PDF]
, 2019 Abstract Heme is an essential cofactor and signaling molecule. All heme-dependent processes require that heme is trafficked from its site of synthesis in the mitochondria to hemoproteins in virtually every subcellular compartment. However, the mechanisms governing the mobilization of heme out of the mitochondria, and the spatio-temporal
Martinez-Guzman, Osiris +5 more
openaire +1 more source
Heme homeostasis and its regulation by hemoproteins in bacteria
mLifeHeme is an important cofactor and a regulatory molecule involved in various physiological processes in virtually all living cellular organisms, and it can also serve as the primary iron source for many bacteria, particularly pathogens.
Yingxi Li, Sirui Han, Haichun Gao
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Microbiology SpectrumHeme is a key co-factor for biologically important proteins that are required for critical cellular functions such as oxygen transport and energy production.
Alicia N. Kreiman +5 more
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L-ferritin binding to scara5: a new iron traffic pathway potentially implicated in retinopathy. [PDF]
PLoS ONE, 2014 Iron is essential in the retina because the heme-containing enzyme guanylate cyclase modulates phototransduction in rods and cones. Transferrin endocytosis is the classical pathway for obtaining iron from the blood circulation in the retina. However, the
Luísa Mendes-Jorge +10 more
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CD36‐mediated lipid rewiring in the metabolic adaptation of tumour ecosystems
The FEBS Journal, EarlyView.Nutrient deprivation drives a lipid‐centric shift in tumour metabolic symbiosis and signalling network. CD36 functions as a bidirectional bridge, transferring fatty acids from stromal donors (adipocytes, CAFs) to the ecosystem tumour‐ and microenvironment‐dependently.
Anna Sebestyén +11 more
wiley +1 more source
Mitochondrial Iron Transport and Homeostasis in Plants
Frontiers in Plant Science, 2013 Iron (Fe) is an essential nutrient for plants and although the mechanisms controlling iron uptake from the soil are relatively well understood, comparatively little is known about subcellular trafficking of iron in plant cells.
Anshika eJain, Erin L Connolly
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