Results 81 to 90 of about 11,782 (206)
Recent Advances in Top‐Down Proteomics for Single‐Cell Research
Mass Spectrometry Reviews, EarlyView.ABSTRACT Individual cells have distinctive molecular characteristics, including biologically relevant proteoforms. Although single‐cell (SC) molecular omics offer unprecedented insights into cellular heterogeneity and function, the characterization of proteoforms in SCs remains an uncharted territory.
Jake A. Melby, Pei Su, Fabio P. Gomes
wiley +1 more source
Utilization Of Heme And Non-Heme Iron Sources During Pregnancy [PDF]
, 2014 Intestinal iron absorption increases during pregnancy to support maternal and fetal iron demands. Although knowledge on non-heme iron absorption has advanced substantially since identification of the hormone hepcidin in 2000, the mechanisms of heme iron ...
Cao, Chang
core
Heme oxygenase is not involved in the anti-proliferative effects of statins on pancreatic cancer cells [PDF]
, 2016 Background: Pancreatic cancer is recognized as one of the most fatal tumors due to its aggressiveness and resistance to therapy. Statins were previously shown to inhibit the proliferation of cancer cells via various signaling pathways.
Vitek, Libor +23 more
core +1 more source
Heme homeostasis and its regulation by hemoproteins in bacteria
mLifeHeme is an important cofactor and a regulatory molecule involved in various physiological processes in virtually all living cellular organisms, and it can also serve as the primary iron source for many bacteria, particularly pathogens.
Yingxi Li, Sirui Han, Haichun Gao
doaj +1 more source
Mitochondrial Iron Transport and Homeostasis in Plants
Frontiers in Plant Science, 2013 Iron (Fe) is an essential nutrient for plants and although the mechanisms controlling iron uptake from the soil are relatively well understood, comparatively little is known about subcellular trafficking of iron in plant cells.
Anshika eJain, Erin L Connolly
doaj +1 more source
L-ferritin binding to scara5: a new iron traffic pathway potentially implicated in retinopathy. [PDF]
PLoS ONE, 2014 Iron is essential in the retina because the heme-containing enzyme guanylate cyclase modulates phototransduction in rods and cones. Transferrin endocytosis is the classical pathway for obtaining iron from the blood circulation in the retina. However, the
Luísa Mendes-Jorge +10 more
doaj +1 more source
Proteins: Structure, Function, and Bioinformatics, EarlyView.ABSTRACT Proteins are built from modular domains that serve as fundamental units of structure and evolution. While individual domains have been extensively cataloged, their collective distribution across the lineages of life has remained poorly resolved.
Rui Guo +5 more
wiley +1 more source
Heme oxygenase isoforms differ in their subcellular trafficking during hypoxia and are differentially modulated by cytochrome P450 reductase. [PDF]
PLoS ONE, 2012 Heme oxygenase (HO) degrades heme in concert with NADPH cytochrome P450 reductase (CPR) which donates electrons to the reaction. Earlier studies reveal the importance of the hydrophobic carboxy-terminus of HO-1 for anchorage to the endoplasmic reticulum (
Monika Linnenbaum +3 more
doaj +1 more source
Cuproptosis Inducers in Cancer Therapy: State of the Art and Challenges
The Chemical Record, EarlyView.Cuproptosis is emerging as a distinct copper‐dependent cell death pathway, highlighting copper as a potential metabolic vulnerability in cancer. This review examines how coordination chemistry, redox regulation, and nanomaterial design shape Cu reactivity and therapeutic outcomes.
Chiara Ragusa, Valentina Oliveri
wiley +1 more source
Molecular insights into frataxin-mediated iron supply for heme biosynthesis in Bacillus subtilis.
PLoS ONE, 2015 Iron is required as an element to sustain life in all eukaryotes and most bacteria. Although several bacterial iron acquisition strategies have been well explored, little is known about the intracellular trafficking pathways of iron and its entry into ...
Andreas Mielcarek +3 more
doaj +1 more source