Results 211 to 220 of about 15,174 (240)

Astroglial gliotransmitters released via Cx43 hemichannels regulate NMDAR‐dependent transmission and short‐term fear memory in the basolateral amygdala

The FASEB Journal, 2022
Astrocytes release gliotransmitters via connexin 43 (Cx43) hemichannels into neighboring synapses, which can modulate synaptic activity and are necessary for fear memory consolidation.
Sergio Linsambarth, Francisco J. Carvajal, R. Moraga-Amaro, Luis Méndez, Giovanni Tamburini, Ivanka Jimenez, Daniela A. Verdugo, Gonzalo I. Gómez, Nur Jury, Pablo Martinez, B. Zundert, Lorena Varela-Nallar, M. Retamal, C. Martin, G. Altenberg, Mariana C. Fiori, W. Cerpa, J. Orellana, J. Stehberg   +18 more
semanticscholar   +1 more source

Hemichannels in Cerebral Ischemia

Current Molecular Medicine, 2009
Hemichannels are transmembrane channels that represent the functional subunits of gap junctions. Each hemichannel is composed of a connexin or pannexin hexamer and, after being transported to the membrane, remains unpaired until it is incorporated in a gap junction. Several studies have already provided evidence that gap junction-mediated intercellular
Panagiotis, Bargiotas, Hannah, Monyer, Markus, Schwaninger   +2 more
openaire   +2 more sources

Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage.

Biochimica et biophysica acta. Molecular cell research, 2020
Both IFN-γ or high glucose have been linked to systemic inflammatory imbalance with serious repercussions not only for endothelial function but also for the formation of the atherosclerotic plaque.
J. Sáez, S. Contreras-Duarte, Valeria C. Labra, Cristian A. Santibáñez, Luis A. Mellado, Carla A Inostroza, Tanhia F. Alvear, M. Retamal, V. Velarde, J. Orellana   +9 more
semanticscholar   +1 more source

Biophysical characterization of zebrafish connexin35 hemichannels

American Journal of Physiology-Cell Physiology, 2004
A subset of connexins can form unopposed hemichannels in expression systems, providing an opportunity for comparison of hemichannel gating properties with those of intact gap junction channels. Zebrafish connexin35 (Cx35) is a member of the Cx35/Cx36 subgroup of connexins highly expressed in the retina and brain.
Virginijus, Valiunas, Rickie, Mui, Elizabeth, McLachlan, Gunnar, Valdimarsson, Peter R, Brink, Thomas W, White   +5 more
openaire   +2 more sources

Functional connexin “hemichannels”: A critical appraisal

Glia, 2006
Abstract“Hemichannels” are defined as the halves of gap junction channels (also termed connexons) that are contributed by one cell; “hemichannels” are considered to be functional if they are open in nonjunctional membranes in the absence of pairing with partners from adjacent cells.
David C, Spray, Zu-Cheng, Ye, Bruce R, Ransom   +2 more
openaire   +2 more sources

Hemichannels: New pathways for gliotransmitter release

Neuroscience, 2015
Growing evidence suggests that glial cells express virtually all known types of neurotransmitter receptors, enabling them to sense neuronal activity and microenvironment changes by responding locally via the Ca(2+)-dependent release of bioactive molecules, known as "gliotransmitters".
Montero, T.D., Orellana Roca, Juan Andrés   +1 more
openaire   +3 more sources

Ischemia Opens Neuronal Gap Junction Hemichannels

Science, 2006
Neuronal excitotoxicity during stroke is caused by activation of unidentified large-conductance channels, leading to swelling and calcium dysregulation. We show that ischemic-like conditions [O 2 /glucose deprivation (OGD)] open hemichannels, or half gap junctions, in neurons.
Roger J, Thompson, Ning, Zhou, Brian A, MacVicar   +2 more
openaire   +2 more sources

Gap junctional hemichannels in the heart

Acta Physiologica Scandinavica, 2003
AbstractUpon contacting each other, cells form gap junctions, in which each cell contributes half of the channel linking their cytoplasms, enabling them to share their metabolome up to a molecular weight of 1000. Each hemichannel (or connexon) is randomly inserted into the plasma membrane and then migrates to the site of cell‐to‐cell contact before ...
S, John, D, Cesario, J N, Weiss
openaire   +2 more sources

Severe neuropathy with leaky connexin32 hemichannels

Annals of Neurology, 2005
AbstractX‐linked Charcot‐Marie‐Tooth disease is one of a set of diseases caused by mutations in gap junction proteins called connexins. We identified a connexin32 missense mutation (F235C) in a girl with unusually severe neuropathy. The localization and trafficking of the mutant protein in cell culture was normal, but electrophysiological studies ...
Grace S Lin, Liang, Marta, de Miguel, Juan M, Gómez-Hernández, Jonathan D, Glass, Steven S, Scherer, Mark, Mintz, Luis C, Barrio, Kenneth H, Fischbeck   +7 more
openaire   +2 more sources

Inhibition of Connexin43 hemichannels with Gap19 protects cerebral ischemia/reperfusion injury via the JAK2/STAT3 pathway in mice.

Brain Research Bulletin, 2019
Functional disruption of the neurovascular unit may lead to aggravation of ischemic cerebral injury. Connexin43 (Cx43)-dependent gap junctional channels (GJCs) are critical in maintaining brain homeostasis. However, excessive opening of hemichannels (HCs)
Beilei Chen, Liu Yang, Jian Chen, Yingzhu Chen, Lingling Zhang, Liangzhu Wang, Xiaobo Li, Yuping Li, Hailong Yu   +8 more
semanticscholar   +1 more source