Results 211 to 220 of about 15,292 (254)
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Hemichannels in Cerebral Ischemia
Current Molecular Medicine, 2009Hemichannels are transmembrane channels that represent the functional subunits of gap junctions. Each hemichannel is composed of a connexin or pannexin hexamer and, after being transported to the membrane, remains unpaired until it is incorporated in a gap junction. Several studies have already provided evidence that gap junction-mediated intercellular
Panagiotis, Bargiotas +2 more
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Functional connexin “hemichannels”: A critical appraisal
Glia, 2006Abstract“Hemichannels” are defined as the halves of gap junction channels (also termed connexons) that are contributed by one cell; “hemichannels” are considered to be functional if they are open in nonjunctional membranes in the absence of pairing with partners from adjacent cells.
David C Spray, Bruce R Ransom
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Ischemia Opens Neuronal Gap Junction Hemichannels
Science, 2006Neuronal excitotoxicity during stroke is caused by activation of unidentified large-conductance channels, leading to swelling and calcium dysregulation. We show that ischemic-like conditions [O 2 /glucose deprivation (OGD)] open hemichannels, or half gap junctions, in neurons.
Ning Zhou, Brian A. MacVicar
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Connexin-based gap junction hemichannels: Gating mechanisms
Biochimica Et Biophysica Acta - Biomembranes, 2005 Connexins (Cxs) form hemichannels and gap junction channels. Each gap junction channel is composed of two hemichannels, also termed connexons, one from each of the coupled cells. Hemichannels are hexamers assembled in the ER, the Golgi, or a post Golgi compartment. They are transported to the cell surface in vesicles and inserted by vesicle fusion, and
Juan C Sáez +2 more
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Paracrine signaling through plasma membrane hemichannels
Biochimica Et Biophysica Acta - Biomembranes, 2013 Plasma membrane hemichannels composed of connexin (Cx) proteins are essential components of gap junction channels but accumulating evidence suggests functions of hemichannels beyond the communication provided by junctional channels. Hemichannels not incorporated into gap junctions, called unapposed hemichannels, can open in response to a variety of ...
Marijke De Bock +2 more
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Biochimica et biophysica acta. Molecular cell research, 2020
Both IFN-γ or high glucose have been linked to systemic inflammatory imbalance with serious repercussions not only for endothelial function but also for the formation of the atherosclerotic plaque.
J. Sáez +9 more
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Both IFN-γ or high glucose have been linked to systemic inflammatory imbalance with serious repercussions not only for endothelial function but also for the formation of the atherosclerotic plaque.
J. Sáez +9 more
semanticscholar +1 more source
Biophysical characterization of zebrafish connexin35 hemichannels
American Journal of Physiology-Cell Physiology, 2004A subset of connexins can form unopposed hemichannels in expression systems, providing an opportunity for comparison of hemichannel gating properties with those of intact gap junction channels. Zebrafish connexin35 (Cx35) is a member of the Cx35/Cx36 subgroup of connexins highly expressed in the retina and brain.
Virginijus, Valiunas +5 more
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Hemichannels: New pathways for gliotransmitter release
Neuroscience, 2015Growing evidence suggests that glial cells express virtually all known types of neurotransmitter receptors, enabling them to sense neuronal activity and microenvironment changes by responding locally via the Ca(2+)-dependent release of bioactive molecules, known as "gliotransmitters".
Montero, T.D. +1 more
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Gap junctional hemichannels in the heart
Acta Physiologica Scandinavica, 2003AbstractUpon contacting each other, cells form gap junctions, in which each cell contributes half of the channel linking their cytoplasms, enabling them to share their metabolome up to a molecular weight of 1000. Each hemichannel (or connexon) is randomly inserted into the plasma membrane and then migrates to the site of cell‐to‐cell contact before ...
S, John, D, Cesario, J N, Weiss
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Severe neuropathy with leaky connexin32 hemichannels
Annals of Neurology, 2005AbstractX‐linked Charcot‐Marie‐Tooth disease is one of a set of diseases caused by mutations in gap junction proteins called connexins. We identified a connexin32 missense mutation (F235C) in a girl with unusually severe neuropathy. The localization and trafficking of the mutant protein in cell culture was normal, but electrophysiological studies ...
Grace S Lin, Liang +7 more
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