Results 21 to 30 of about 3,374,032 (169)

Studying protein-protein interactions using peptide arrays [PDF]

, 2010
Screening of arrays and libraries of compounds is well-established as a high-throughput method for detecting and analyzing interactions in both biological and chemical systems. Arrays and libraries can be composed from various types of molecules, ranging
Rito, T., Rudiger, S.G.D., Sub Cellular Protein Chemistry, Rotem-Bamberger, S., Katz, C., Friedler, A., Levy-Beladev, L., Cellular Protein Chemistry   +7 more
core   +1 more source

Time-course analysis of serum hepcidin, iron and cytokines in a C282Y homozygous patient with Schnitzler’s syndrome treated with IL-1 receptor antagonist

Haematologica, 2009
It is currently unknown if the increase of the hepatic iron regulatory hormone hepcidin during inflammation in man depends on an intact HFE-protein. Here we describe the temporal relationship of serum hepcidin, serum iron and cytokines in a patient with ...
Marcel van Deuren, Joyce J. C. Kroot, Dorine W. Swinkels   +2 more
doaj   +1 more source

Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]

, 2002
As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem, Priem, F, Kaufmann, Stefan HE, Collins, Helen L, Ulrich E. Schaible, Kaufmann, S H E, Schaible, Ulrich E, Helen L. Collins, Collins, H L, Priem, Friedrich, Stefan H.E. Kaufmann, Schaible, U E   +11 more
core   +1 more source

Hemojuvelin N-terminal mutants reach the plasma membrane but do not activate the hepcidin response

Haematologica, 2008
Background Hemojuvelin is a glycosylphosphatidylinositol-anchored protein, expressed in liver, skeletal muscle and heart. As a co-receptor of bone morphogenetic protein, membrane hemojuvelin positively modulates the iron regulator hepcidin.
Alessia Pagani, Laura Silvestri, Antonella Nai, Clara Camaschella   +3 more
doaj   +1 more source

Hemochromatosis-like disease in Brazilian tapirs (Tapirus terrestris) in Pará state, Brazil

, 2022
We report two cases of hemochromatosis-like disease in captive Brazilian tapirs, Tapirus terrestris in Pará state, Brazil. Both animals presented symptoms of chronic hepatopathy associated with marked accumulation of hemosiderin.
Rosekelly de Jesus CARDOSO (14224421), Pedro Soares BEZERRA JUNIOR (14224442), Alessandra Scofield AMARAL (14224445), Natalia Maxine F. P. SARMENTO (14224424), Valíria Duarte CERQUEIRA (14224448), Gerson Bladimir Escobar GONZALEZ (14224433), Gabriela RIET-CORREA (14224436), Manoel Ananis Lopes SOARES (14224439), Márcio Alan Oliveira MOURA (14224430), Arieli Sousa de OLIVEIRA (14224427), Adrielli Heloise dos Anjos LIMA (14224415), Américo Meirelles NETO (14224418)   +11 more
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Hereditary hemochromatosis: pathogenesis, symptoms, diagnosis and current treatment - literature review

Journal of Education, Health and Sport
Introduction: Hereditary hemochromatosis is the most common genetic disorder in Northern Europe. It involves an overload of iron in the tissues due to a deficiency of the protein hepcidin.
Dominika Prystacka-Szar, Natalia Rulewska, Filip Grabowski, Jakub Siemko, Dagmara Neska , Justyna Stadler-Szajda, Adrianna Czyżnikiewicz, Wenancjusz Stołowski, Magdalena Bujak, Magdalena Waśniowska   +9 more
doaj   +1 more source

The extrahepatic role of TFR2 in iron homeostasis

Frontiers in Pharmacology, 2014
Transferrin receptor 2 (TFR2), a protein homologous to the cell iron importer transferrin receptor 1 (TFR1), is expressed in the liver and erythroid cells and is reported to bind diferric transferrin, although at lower affinity than TFR1.
Laura eSilvestri, Antonella eNai, Alessia ePagani, Clara eCamaschella   +3 more
doaj   +1 more source

Genetic disruption of NRF2 promotes the development of necroinflammation and liver fibrosis in a mouse model of HFE-hereditary hemochromatosis

Redox Biology, 2017
Background and Aims: In hereditary hemochromatosis, iron deposition in the liver parenchyma may lead to fibrosis, cirrhosis and hepatocellular carcinoma.
Tiago L. Duarte, Carolina Caldas, Ana G. Santos, Sandro Silva-Gomes, Andreia Santos-Gonçalves, Maria João Martins, Graça Porto, José Manuel Lopes   +7 more
doaj   +1 more source

HFE (hemochromatosis) [PDF]

, 2009
Review on HFE (hemochromatosis), with data on DNA, on the protein encoded, and where the gene is ...
Dorak, MT, MT Dorak
core   +1 more source

CHAPTER 1.1. Disulfide Bonds in Protein Folding and Stability [PDF]

, 2018
Disulfide bonds are unique among post-translational modifications, as they add covalent crosslinks to the polypeptide chain. Accordingly, they can exert pronounced effects on protein folding and stability. This is of particular importance for secreted or
Sub Cellular Protein Chemistry, Hendershot, Linda M., Feige, Matthias J., Ineke Braakman, Matthias J. Feige, Braakman, Ineke, Cellular Protein Chemistry, Linda M. Hendershot   +7 more
core   +1 more source