Results 41 to 50 of about 3,374,032 (169)

Deficiency of heme-regulated eIF2α kinase decreases hepcidin expression and splenic iron in HFE−/− mice

Haematologica, 2008
Heme-regulated eIF2α kinase (HRI) is essential for regulating globin translation in iron deficiency and in β-thalassemia. We investigated the role of heme-regulated eIF2α kinase in hemoglobin and red blood cell production as well as in iron homeostasis ...
Sijin Liu, Rajasekhar N.V.S. Suragani, Anping Han, Wanting Zhao, Nancy C. Andrews, Jane-Jane Chen   +5 more
doaj   +1 more source

Differential HFE gene expression is regulated by alternative splicing in human tissues. [PDF]

PLoS ONE, 2011
The pathophysiology of HFE-derived Hereditary Hemochromatosis and the function of HFE protein in iron homeostasis remain uncertain. Also, the role of alternative splicing in HFE gene expression regulation and the possible function of the corresponding ...
Rute Martins, Bruno Silva, Daniela Proença, Paula Faustino   +3 more
doaj   +1 more source

Probiotics and intestinal permeability in adults with metabolic dysfunction‐associated steatohepatitis: A secondary analysis of a randomized clinical trial

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Metabolic dysfunction‐associated steatohepatitis (MASH) is associated with altered intestinal permeability, allowing microbial products to translocate to the liver via the enterohepatic circulation and contributes to disease progression. The aim of our study was to evaluate the association between probiotic supplementation and serum
Bruna Concheski de Moura, Samanta Catherine Ferreira, Amanda Souza Silva‐Sperb, Helena Abadie Moraes, Larisse Longo, Carolina Uribe‐Cruz, Matheus Truccolo Michalczuk, Themis Reverbel da Silveira, Carlos Thadeu Schmidt Cerski, Mário Reis Álvares da Silva, Valesca Dall'Alba   +10 more
wiley   +1 more source

HLA determinants in an Australian population of hemochromatosis patients and their families [PDF]

, 1989
The frequencies of different HLA-A and -B alleles in 77 Australian patients with hemochromatosis have been compared with frequencies of HLA alleles not associated with hemochromatosis in 63 of their heterozygous relatives and with published population ...
Tam, K S, Halliday, J W, Summers, K M, Powell, L W   +3 more
core  

Hemojuvelin is essential for transferrin-dependent and transferrin-independent hepcidin expression in mice

Haematologica, 2012
Here we investigate the regulation of hepcidin, a hormone that inhibits dietary iron absorption and macrophage iron recycling, by the serum iron-binding protein transferrin.
Thomas B. Bartnikas, Mark D. Fleming
doaj   +1 more source

Novel mutation in ferroponin1 is associated with autosomal dominant hemochromatosis

, 2002
Hemochromatosis is a common disorder characterized by excess iron absorption and accumulation of iron in tissues. Usually hemochromatosis is inherited in an autosomal recessive pattern and is caused by mutations in the HFE gene.
Stephenson, Peter, Wallace, D.F., Subramaniam, V. Nathan, Stephenson, P., Searle, J.W., Dixon, Jeannette L., Powell, Lawrie W., Pedersen, P., Pedersen, Palle, Dixon, J.L., Powell, L.W., Wallace, Daniel F., Searle, Jeffrey W., Subramaniam, V.N.   +13 more
core   +1 more source

Crosstalk between Acidosis and Iron Metabolism: Data from In Vivo Studies

Metabolites, 2022
Iron absorption requires an acidic environment that is generated by the activity of the proton pump gastric H(+)/K(+)ATPase (ATP4), expressed in gastric parietal cells.
Raêd Daher, Nicolas Ducrot, Thibaud Lefebvre, Sofia Zineeddine, Jérome Ausseil, Hervé Puy, Zoubida Karim   +6 more
doaj   +1 more source

Microbial communities and functional diversity in seafood

JSFA reports, EarlyView.
Abstract Functional diversity encompasses ecosystem processes that enhance adaptability to environmental change. This study explores the diversity of microorganisms associated with seafood. In this paper, we present our knowledge of microbial diversity in relation to seafood.
Christian Larbi Ayisi, Samuel Ayeh Osei, Grace Afumwaa Boamah, Gertrude Dzifa Mensah   +3 more
wiley   +1 more source

Hemojuvelin and bone morphogenetic protein (BMP) signaling in iron homeostasis

Frontiers in Pharmacology, 2014
Mutations in hemojuvelin (HJV) are the most common cause of the juvenile-onset form of the iron overload disorder hereditary hemochromatosis. The discovery that HJV functions as a co-receptor for the bone morphogenetic protein (BMP) family of signaling ...
Amanda B Core, Susanna eCanali, Jodie L. Babitt   +2 more
doaj   +1 more source

Restrictive cardiomyopathy: from genetics and clinical overview to animal modeling

Reviews in Cardiovascular Medicine, 2022
Restrictive cardiomyopathy (RCM), a potentially devastating heart muscle disorder, is characterized by diastolic dysfunction due to abnormal muscle relaxation and myocardial stiffness resulting in restrictive filling of the ventricles.
Michelle Chintanaphol, Buyan-Ochir Orgil, Neely R. Alberson, Jeffrey A. Towbin, Enkhsaikhan Purevjav   +4 more
doaj   +1 more source