Results 91 to 100 of about 13,066 (196)

Long-term outcome of a randomized controlled study in patients with newly diagnosed severe aplastic anemia treated with antithymocyte globulin and cyclosporine, with or without granulocyte colony-stimulating factor: a Severe Aplastic Anemia Working Party Trial from the European Group of Blood and Marrow Transplantation

Haematologica, 2020
This follow-up study of a randomized, prospective trial included 192 patients with newly diagnosed severe aplastic anemia receiving antithymoglobulin and cyclosporine, with or without granulocyte colony-stimulating factor (G-CSF).
André Tichelli, Régis Peffault de Latour, Jakob Passweg, Cora Knol-Bout, Gérard Socié, Judith Marsh, Hubert Schrezenmeier, Britta Höchsmann, Andrea Bacigalupo, Sujith Samarasinghe, Alicia Rovó, Austin Kulasekararaj, Alexander Röth, Dirk-Jan Eikema, Paul Bosman, Peter Bader, Antonio Risitano, Carlo Dufour   +17 more
doaj   +1 more source

Nicotinamide Attenuates Complement and Coagulation Pathways and Resultant Renal Fibrosis

The FASEB Journal, Volume 39, Issue 23, 15 December 2025.
The coagulation and complement cascades were elevated in the pathogenesis of chronic kidney disease (CKD) and may contribute to both kidney injury and cardiovascular risk. These excessive signals and the associated innate immune responses were suppressed by the NAD+ precursor nicotinamide (NAM).
Saori Kin, Yuji Oe, Taku Obara, Emiko Sato, Nobuyuki Takahashi, Mariko Miyazaki, Tetsuhiro Tanaka   +6 more
wiley   +1 more source

Unusual Etiology of Budd‐Chiari Syndrome in an Adolescent: A Case of Combined Thrombophilic Disorder

Clinical Case Reports, Volume 13, Issue 12, December 2025.
ABSTRACT Budd‐Chiari syndrome (BCS) is an uncommon but potentially life‐threatening hepatic vascular disorder resulting from obstruction of the hepatic venous outflow. While it predominantly affects adults, pediatric and adolescent presentations are rare, particularly those associated with inherited thrombophilia.
Santosh Sah, Rumaisa Riaz, Afsheen Khan, Tularam Yadav, Kirshan Lal, Hussain Haider Shah   +5 more
wiley   +1 more source

Autoimmune hemolytic anemia in children

Pediatric Hematology Oncology Journal
Autoimmune hemolytic anaemia (AIHA) is an uncommon cause of antibody-induced hemolytic anemia in children. It is divided into three categories: warm AIHA, cold antibody AIHA and paroxysmal cold hemoglobinuria. The diagnostic work-up typically begins with
Dinesh Chandra, Varun Capoor, Ayoniza Maitri, Rahul Naithani   +3 more
doaj   +1 more source

Induction of Prostaglandin Release from Macrophages by Bacterial Endotoxin [PDF]

, 2017
This review summarizes the role of the monocytic responses to lipopolysaccharide as it relates to periodontal disease severity. Data are presented which illustrate that the levels of prostaglandin E2 (PGE2) secreted by systemic peripheral blood monocytes
Offenbacher, S., Salvi, G. E.
core  

Massive Intravascular Hemolysis in a Patient Infected by a Clostridium perfringens [PDF]

, 2006
Clostridium perfringens infection is a very rare cause of massive intravascular hemolysis, but it should always be kept in mind, since only early treatment can rescue patients from an otherwise rapidly fatal outcome.
Harada, Kimiko, Himei, Masahiro, Kawata, Masashi, Murakami, Kazuharu, Ohtani, Shoichiro, Watanabe, Naomi   +5 more
core   +1 more source

Population Pharmacokinetic and Pharmacokinetic/Pharmacodynamic Analyses of Pegcetacoplan in Patients with Paroxysmal Nocturnal Hemoglobinuria

Drugs in R&D
Background and Objective Paroxysmal nocturnal hemoglobinuria is a rare blood disorder characterized by life-threatening hemolysis and thrombosis. Complement C5 inhibitor therapy improves symptoms and life prognosis; however, it can result in insufficient
Ryan L. Crass, Brandon Smith, Sven Adriaens, Sunny Chapel, Grant Langdon   +4 more
doaj   +1 more source

Function of Soluble CD14 in Serum from Patients with Septic Shock [PDF]

, 2017
Soluble CD14 (sCD14) mediates lipopolysaccharide (LPS) activation of epithelial cells in vitro and may thereby be harmful in sepsis.sCD14 function was analyzed in sera from 62 patients with septic shock and compared with data from appropriate controls ...
Landmann, Regine, Reber, Anne Marie, Sansano, Sebastiano, Zimmerli, Werner   +3 more
core  

Absence of CD59 in guinea pigs: Analysis of the Cavia porcellus genome suggests the evolution of a CD59 pseudogene [PDF]

, 2018
CD59 is a membrane-bound regulatory protein that inhibits the assembly of the terminal membrane attack complex (C5b-9) of complement. From its original discovery in humans almost 30 years ago, CD59 has been characterized in a variety of species, from ...
Boshra, Hani, Hughes, Timothy R., Morgan, B. Paul, Rodriguez de Cordoba, Santiago, Zelek, Wioleta M.   +4 more
core   +1 more source

Hemosiderin tubulopathy-induced acute kidney injury - A rare initial manifestation of paroxysmal nocturnal hemoglobinuria

Saudi Journal of Kidney Diseases and Transplantation, 2018
Paroxysmal nocturnal hemoglobinuria (PNH) is characterized by episodes of intravascular hemolysis, infections, and thromboembolic complications. Renal abnormalities are rare which occur either due to hemolytic crisis or repeated thrombotic episodes ...
Srikanth Prasad Rao, Sindhura Lakshmi Koulmane Laxminarayana, Shankar Prasad Nagaraju, Mahesha Vankalakunti, Ravindra Prabhu Attur, Chethan Manohar   +5 more
doaj   +1 more source