Results 41 to 50 of about 6,457,465 (175)

Characterization of Interstrand DNA–DNA Cross-Links Using the α-Hemolysin Protein Nanopore [PDF]

ACS Nano, 2015
Nanopore-based sensors have been studied extensively as potential tools for DNA sequencing, characterization of epigenetic modifications such as 5-methylcytosine, and detection of microRNA biomarkers. In the studies described here, the α-hemolysin protein nanopore embedded in a lipid bilayer was used for the detection and characterization of ...
Xinyue, Zhang, Nathan E, Price, Xi, Fang, Zhiyu, Yang, Li-Qun, Gu, Kent S, Gates   +5 more
openaire   +2 more sources

Genome-wide CRISPR screen reveals novel host factors required for Staphylococcus aureus α-hemolysin-mediated toxicity

Scientific Reports, 2016
Staphylococcus aureus causes a wide variety of infections and antibiotic resistant strains are a major problem in hospitals. One of the best studied virulence factors of S.
Sebastian Virreira Winter, A. Zychlinsky, Bart W Bardoel   +2 more
semanticscholar   +1 more source

Pore-Forming Toxin-Like Proteins in the Anti-Parasitoid Immune Response of Drosophila

Journal of Innate Immunity
Introduction: Species of the ananassae subgroup of Drosophilidae are highly resistant to parasitoid wasp infections. We have previously shown that the genes encoding cytolethal distending toxin B (CdtB) and the apoptosis inducing protein of 56
Lilla B. Magyar, Edit Ábrahám, Zoltán Lipinszki, Rebecca L. Tarnopol, Noah K. Whiteman, Viktória Varga, Dan Hultmark, István Andó, Gyöngyi Cinege   +8 more
doaj   +1 more source

Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell

Scientific Reports, 2022
Many proteins of the Repeats in Toxins (RTX) protein family are toxins of Gram-negative pathogens including hemolysin A (HlyA) of uropathogenic E. coli. RTX proteins are secreted via Type I secretion systems (T1SS) and adopt their native conformation in ...
Isabelle N. Erenburg, Sebastian Hänsch, Feby M. Chacko, Anna Hamacher, Sebastian Wintgens, Fabian Stuhldreier, Gereon Poschmann, Olivia Spitz, Kai Stühler, Sebastian Wesselborg, Johannes H. Hegemann, Sander H. J. Smits, Stefanie Weidtkamp-Peters, Lutz Schmitt   +13 more
doaj   +1 more source

Platelets, Bacterial Adhesins and the Pneumococcus

Cells, 2022
Systemic infections with pathogenic or facultative pathogenic bacteria are associated with activation and aggregation of platelets leading to thrombocytopenia and activation of the clotting system.
Kristin Jahn, Thomas P. Kohler, Lena-Sophie Swiatek, Sergej Wiebe, Sven Hammerschmidt   +4 more
doaj   +1 more source

Determination of the antibacterial effect of bee venom against rainbow trout pathogens and antibiotic resistance gene expression

Acta Veterinaria, 2023
Bee venom (BV) is a rich source of secondary metabolites from honeybees (Apis mellifera L.). It contains a variety of bioactive ingredients including peptides, proteins, enzymes, and volatile metabolites. This study investigated the antibacterial effects
Kabakci Dilek, Ürkü Çiğdem, Önalan Şükrü   +2 more
doaj   +1 more source

Directionality of substrate translocation of the hemolysin A Type I secretion system

Scientific Reports, 2015
Type 1 secretion systems (T1SS) of Gram-negative bacteria are responsible for the secretion of various proteases, lipases, S-layer proteins or toxins into the extracellular space.
Michael H. H. Lenders, S. Weidtkamp‐Peters, Diana Kleinschrodt, K. Jaeger, S. Smits, L. Schmitt   +5 more
semanticscholar   +1 more source

Escherichia coli Strain – Super-Producer of Vibrio cholerae Hemolysin

Проблемы особо опасных инфекций, 2018
Objective of this work was the cloning of Vibrio cholerae hlyA gene in a plasmid vector providing expression of foreign genes under the control of T5 promoter, and construction of E.
E. V. Monakhova, R. V. Pisanov, G. V. Demidova, N. B. Nepomnyashchaya   +3 more
doaj   +1 more source

Functions of a hemolysin-like protein in the cyanobacterium Synechocystis sp. PCC 6803 [PDF]

Archives of Microbiology, 2011
A glucose-tolerant strain of the cyanobacterium Synechocystis sp. PCC 6803, generally referred to as wild type, produces a hemolysin-like protein (HLP) located on the cell surface. To analyze the function of HLP, we constructed a mutant in which the hlp gene was disrupted.
Tetsushi, Sakiyama, Hiroya, Araie, Iwane, Suzuki, Yoshihiro, Shiraiwa   +3 more
openaire   +2 more sources

Roles of Hcp family proteins in the pathogenesis of the porcine extraintestinal pathogenic Escherichia coli type VI secretion system

Scientific Reports, 2016
Hcp (hemolysin-coregulated protein) is considered a vital component of the functional T6SS (Type VI Secretion System), which is a newly discovered secretion system.
Ying Peng, Xiangru Wang, Jin Shou, Bingbing Zong, Yanyan Zhang, Jia Tan, Jing Chen, Linlin Hu, Yongwei Zhu, Huanchun Chen, Chen Tan   +10 more
semanticscholar   +1 more source