Results 41 to 50 of about 6,249 (178)

Plasma Heme Scavengers Alpha-1-Microglobulin and Hemopexin as Biomarkers in High-Risk Pregnancies

Frontiers in Physiology, 2019
Women with established preeclampsia (PE) have increased plasma concentration of free fetal hemoglobin. We measured two hemoglobin scavenger system proteins, hemopexin (Hpx) and alpha-1-microglobulin (A1M) in maternal plasma using enzyme-linked ...
Grigorios Kalapotharakos, Grigorios Kalapotharakos, Katja Murtoniemi, Katja Murtoniemi, Bo Åkerström, Esa Hämäläinen, Esa Hämäläinen, Eero Kajantie, Eero Kajantie, Eero Kajantie, Katri Räikkönen, Pia Villa, Hannele Laivuori, Hannele Laivuori, Hannele Laivuori, Hannele Laivuori, Stefan R. Hansson, Stefan R. Hansson   +17 more
doaj   +1 more source

Scavenging of Labile Heme by Hemopexin Is a Key Checkpoint in Cancer Growth and Metastases

Cell Reports, 2020
Summary: Hemopexin (Hx) is a scavenger of labile heme. Herein, we present data defining the role of tumor stroma-expressed Hx in suppressing cancer progression.
Giacomo Canesin, Annalisa Di Ruscio, Mailin Li, Simone Ummarino, Andreas Hedblom, Reeham Choudhury, Agnieszka Krzyzanowska, Eva Csizmadia, Macarena Palominos, Anna Stiehm, Alexander Ebralidze, Shao-Yong Chen, Mahmoud A. Bassal, Ping Zhao, Emanuela Tolosano, Laurence Hurley, Anders Bjartell, Daniel G. Tenen, Barbara Wegiel   +18 more
doaj   +1 more source

Perinatal Metabolism of Hemopexin and Heme

Experimental Biology and Medicine, 1971
SummarySera from fetal, newborn, and juvenile rabbits were found to have lower Hx levels than those of their mothers but approached the normal adult range by 30 to 60 days of age. Inadequate materno-fetal transport of Hx contributed to low fetal and neonatal serum levels, since only small amounts of homologous 125I-Hx passed from the maternal ...
J D, Ross, H H, Liem, U, Muller-Eberhard
openaire   +2 more sources

Proteomic Analysis of Golden Sputum Reveals Pulmonary Complement Activation During Acute Chest Syndrome in Children With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Acute chest syndrome (ACS) is one of the most common severe complications of sickle cell disease (SCD). In recent years, a major role of inflammation and innate immunity has been evidenced, but ACS pathophysiology remains incompletely understood, and therapeutic options are limited.
Slimane Allali, Nabiha Sbeih, Rachel Rignault‐Bricard, Johanna Bruce, Morgane Le Gall, Claire Heilbronner, Noemie de Cacqueray, Sofia Angyalosy, Melissa Taylor, Joséphine Brice, Mariane de Montalembert, Martina Bevacqua, Emilie‐Fleur Gautier, Olivier Hermine, Thiago Trovati Maciel   +14 more
wiley   +1 more source

Hemopexin regulates acute-phase inflammatory response against pathogenetic infections in black rockfish (Sebastes schlegelii)

Comparative Immunology Reports
Hemopexin as an acute-phase protein binds heme with a high affinity and participates in a variety of processes of physiology and pathology. Hemopexin plays an important role in regulating inflammatory response by regulating pro-/anti-inflammatory ...
Chengbin Gao, Peng Sun, Xin Cai, Mengyu Tian, Chao Li   +4 more
doaj   +1 more source

Host Iron Nutritional Immunity Induced by a Live Yersinia pestis Vaccine Strain Is Associated with Immediate Protection against Plague

Frontiers in Cellular and Infection Microbiology, 2017
Prompt and effective elicitation of protective immunity is highly relevant for cases of rapidly deteriorating fatal diseases, such as plague, which is caused by Yersinia pestis. Here, we assessed the potential of a live vaccine to induce rapid protection
Ayelet Zauberman, Yaron Vagima, Avital Tidhar, Moshe Aftalion, David Gur, Shahar Rotem, Theodor Chitlaru, Yinon Levy, Emanuelle Mamroud   +8 more
doaj   +1 more source

Endothelial Barrier Integrity Is Disrupted In Vitro by Heme and by Serum From Sickle Cell Disease Patients

Frontiers in Immunology, 2020
Free extracellular heme has been shown to activate several compartments of innate immunity, acting as a danger-associated molecular pattern (DAMP) in hemolytic diseases.
Vanessa Araujo Gomes Santaterra, Maiara Marx Luz Fiusa, Bidossessi Wilfried Hounkpe, Francine Chenou, Wouitchekpo Vincent Tonasse, Loredana Nilkenes Gomes da Costa, Loredana Nilkenes Gomes da Costa, Diego Garcia-Weber, Igor de Farias Domingos, Igor de Farias Domingos, Franciele de Lima, Ivanio Teixeira Borba-Junior, Aderson da Silva Araújo, Antonio Roberto Lucena-Araújo, Marcos André Cavalcante Bezerra, Magnun Nueldo Nunes dos Santos, Fernando Ferreira Costa, Fernando Ferreira Costa, Jaime Millán, Erich Vinicius De Paula, Erich Vinicius De Paula   +20 more
doaj   +1 more source

Effect of Red Blood Cell Transfusion on Inflammatory and Angiogenic Pathways in Patients With Sickle Cell Disease

American Journal of Hematology, EarlyView.
ABSTRACT Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown.
Lydian A. de Ligt, Sanjay R. Thakoerdin, Maud Zwolsman, Gaby Stegemann, Hanke Matlung, Taco W. Kuijpers, Bart J. Biemond, Karin Fijnvandraat, Robin van Bruggen, Erfan Nur   +9 more
wiley   +1 more source

Chlorine inhalation induces acute chest syndrome in humanized sickle cell mouse model and ameliorated by postexposure hemopexin

Redox Biology, 2021
Triggering factors of Acute Chest Syndrome (ACS) is a leading cause of death in patients with Sickle Cell Disease (SCD) and targeted therapies are limited.
Ammar Saadoon Alishlash, Muna Sapkota, Israr Ahmad, Kelsey Maclin, Noor A. Ahmed, Adam Molyvdas, Stephen Doran, Carolyn J. Albert, Saurabh Aggarwal, David A. Ford, Namasivayam Ambalavanan, Tamas Jilling, Sadis Matalon   +12 more
doaj   +1 more source

Protein glycosylation in lung cancer from a mass spectrometry perspective

Mass Spectrometry Reviews, EarlyView.
Abstract Lung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer.
Mirjam Balbisi, Simon Sugár, Lilla Turiák   +2 more
wiley   +1 more source