Results 51 to 60 of about 6,249 (178)

Analysis of the Matrix Metalloproteinases Family Profile in Gastric Cancer Suggests Key Matrix Metalloproteinases for Tumor Development and Their Clinical Impact

Molecular Carcinogenesis, EarlyView.
ABSTRACT Gastric cancer (GC) is the fifth most common type worldwide, representing a public health problem. Among the genes related to this tumorigenesis, the family of matrix metalloproteinases (MMPs), essential regulators of the extracellular matrix (ECM), stand out for their involvement in the development and progression of GC.
Aline Costa Bastos, André Salim Khayat, Emanuele Raimunda Louzada Moraes, Ágatha Tereza Miranda Tavares, Ronald Matheus da Silva Mourão, Fabiano Cordeiro Moreira, Samir Mansour Moraes Casseb, Samia Demachki, Geraldo Ishak, Williams Fernandes Barra, Rommel Mario Rodríguez Burbano, Paulo Pimentel de Assumpção   +11 more
wiley   +1 more source

Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells

Frontiers in Physiology, 2018
Accumulation of damaged or misfolded proteins resulted from oxidative protein modification induces endoplasmic reticulum (ER) stress by activating the pathways of unfolded protein response.
Tamás Gáll, Tamás Gáll, Dávid Pethő, Annamária Nagy, Zoltán Hendrik, Gábor Méhes, László Potor, László Potor, Magnus Gram, Bo Åkerström, Ann Smith, Péter Nagy, György Balla, György Balla, József Balla, József Balla   +15 more
doaj   +1 more source

Skeletal muscle atrophy‐induced hemopexin accelerates onset of cognitive impairment in Alzheimer's disease

Journal of Cachexia, Sarcopenia and Muscle, 2021
Background Alzheimer's disease (AD) is an unmet medical need worldwide, and physical inactivity is a risk factor for AD. Performing physical exercise is difficult at old age, and thus, decline in physical movement may be a cause of age‐associated ...
Tsukasa Nagase, Chihiro Tohda
doaj   +1 more source

Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus

Frontiers in Immunology, 2022
ObjectivesSerial kidney biopsy for repeat evaluation and monitoring of lupus nephritis (LN) in childhood-onset Systemic Lupus Erythematosus (cSLE) remains challenging, thus non-invasive biomarkers are needed.
Samar A. Soliman, Samar A. Soliman, Anam Haque, Kamala Vanarsa, Ting Zhang, Faten Ismail, Kyung Hyun Lee, Claudia Pedroza, Larry A. Greenbaum, Sherene Mason, M. John Hicks, Scott E. Wenderfer, Chandra Mohan   +12 more
doaj   +1 more source

Extracellular matrix and proteolysis: mechanisms driving irreversible changes and shaping cell behavior

The FEBS Journal, EarlyView.
Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley   +1 more source

PsEND1 Is a Key Player in Pea Pollen Development Through the Modulation of Redox Homeostasis

Frontiers in Plant Science, 2021
Redox homeostasis has been linked to proper anther and pollen development. Accordingly, plant cells have developed several Reactive Oxygen Species (ROS)-scavenging mechanisms to maintain the redox balance.
Rim Hamza, Edelín Roque, Concepción Gómez-Mena, Francisco Madueño, José Pío Beltrán, Luis A. Cañas   +5 more
doaj   +1 more source

Interactions of Porphyrins with Rabbit Hemopexin

Journal of Biological Chemistry, 1972
Abstract The formation of complexes of rabbit hemopexin with a representative group of porphyrins was investigated to determine the stoichiometry and estimated dissociation constants (Kd) as well as the effect of pH on these interactions. In a 1:1 molar ratio, rabbit apohemopexin (RHx) binds iron-protoporphyrin IX (heme), iron-deuteroporphyrin IX ...
W T, Morgan, U, Muller-Eberhard
openaire   +2 more sources

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

Hyaluronan‐binding properties of human serum hemopexin

FEBS Letters, 1996
Hemopexin, the heme‐binding serum glycoprotein, exhibits a complex electrophoretic pattern on two‐dimensional immunoelectrophoresis on agarose gels into which hyaluronic acid is incorporated in the first and monospecific anti‐hemopexin in the second dimension.
Hrkal, Z., Kuzelová, K., Muller-Eberhard, U., Stern, R.   +3 more
openaire   +2 more sources

Matrix Metalloproteinases in Periodontal and Peri‐Implant Diseases: Contribution to Their Pathogenesis, Diagnosis, and Treatment

Journal of Periodontal Research, EarlyView.
This graphical abstract illustrates the role of matrix metalloproteinases (MMPs) across the pathogenesis, diagnosis, and therapeutics of periodontal and peri‐implant diseases. Microbial and host stimuli trigger MMP activation leading to extracellular matrix breakdown, point‐of‐care aMMP‐8 detection aids diagnosis, and adjunctive or AI‐assisted ...
Timo Sorsa, Lorne M. Golub, Julie Toby Thomas, Pietro Leone, Sukumaran Anil, Veli‐Jukka Uitto   +5 more
wiley   +1 more source