Results 31 to 40 of about 3,651 (163)

Animal Challenge Models of Henipavirus Infection and Pathogenesis [PDF]

, 2012
The henipaviruses, Hendra virus (HeV), and Nipah virus (NiV), are enigmatic emerging pathogens that causes severe and often fatal neurologic and/or respiratory disease in both animals and humans. Amongst people, case fatality rates range between 40 and 75% and there are no vaccines or treatments approved for human use.
Geisbert, Thomas W., Feldmann, Heinz, Broder, Christopher C.   +2 more
openaire   +2 more sources

Type I Interferon Signaling Protects Mice From Lethal Henipavirus Infection [PDF]

The Journal of Infectious Diseases, 2012
Hendra virus (HeV) and Nipah virus (NiV) are closely related, recently emerged paramyxoviruses that form Henipavirus genus and are capable of causing considerable morbidity and mortality in a number of mammalian species, including humans. However, in contrast to many other species and despite expression of functional virus entry receptors, mice are ...
Dhondt, Kévin P, Mathieu, Cyrille, Chalons, Marie, Reynaud, Joséphine M, Vallve, Audrey, Raoul, Hervé, Horvat, Branka   +6 more
openaire   +4 more sources

Computational Approaches for Structure-Based Molecular Characterization and Functional Annotation of the Fusion Protein of Nipah henipavirus

Chemistry Proceedings, 2022
Throughout history, viral epidemics of varying frequency and intensity have been responsible for inducing panic and causing widespread damage. The Nipah virus has one of the highest rates of fatalities of any infectious disease in the world.
Abu Saim Mohammad Saikat, Ranjit Chandra Das, Madhab Chandra Das   +2 more
doaj   +1 more source

Inhibition of Henipavirus infection by RNA interference

Antiviral Research, 2008
Nipah virus (NiV) and Hendra virus (HeV) are recently emerged zoonotic paramyxoviruses exclusively grouped within a new genus, Henipavirus. These viruses cause fatal disease in a wide range of species, including humans. Both NiV and HeV have continued to re-emerge sporadically in Bangladesh and Australia, respectively.
Mungall, Bruce A., Schopman, Nick C.T., Lambeth, Luke S., Doran, Tim J.   +3 more
openaire   +2 more sources

Interferon Signaling Remains Functional during Henipavirus Infection of Human Cell Lines [PDF]

Journal of Virology, 2011
ABSTRACT Henipaviruses encode several proteins from the P gene, of which V and W have been demonstrated by gene-based transfection studies to antagonize the innate immune response, blocking both type I interferon production and signaling. This study examines the effects of henipavirus infection on the innate immune response in human cell ...
Elena R, Virtue, Glenn A, Marsh, Lin-Fa, Wang   +2 more
openaire   +2 more sources

Evidence of Henipavirus Infection in West African Fruit Bats

PLoS ONE, 2008
(Uploaded by Plazi for the Bat Literature Project) Henipaviruses are emerging RNA viruses of fruit bat origin that can cause fatal encephalitis in man. Ghanaian fruit bats (megachiroptera) were tested for antibodies to henipaviruses. Using a Luminex multiplexed microsphere assay, antibodies were detected in sera of Eidolon helvum to both Nipah (39%, 95%
David T. S. Hayman, Richard Suu‐Ire, Andrew C. Breed, Jennifer A. McEachern, Lin‐Fa Wang, James Wood, Andrew A. Cunningham   +6 more
openaire   +5 more sources

Anti-viral drug discovery against monkeypox and smallpox infection by natural curcumin derivatives: A Computational drug design approach

Frontiers in Cellular and Infection Microbiology, 2023
BackgroundIn the last couple of years, viral infections have been leading the globe, considered one of the most widespread and extremely damaging health problems and one of the leading causes of mortality in the modern period.
Shopnil Akash, Arafat Hossain, Md. Sarowar Hossain, Md. Mominur Rahman, Mohammad Z. Ahmed, Nemat Ali, Martin Valis, Kamil Kuca, Kamil Kuca, Rohit Sharma   +9 more
doaj   +1 more source

The Intrinsically Disordered W Protein Is Multifunctional during Henipavirus Infection, Disrupting Host Signalling Pathways and Nuclear Import [PDF]

Cells, 2020
Nipah and Hendra viruses are highly pathogenic, zoonotic henipaviruses that encode proteins that inhibit the host’s innate immune response. The W protein is one of four products encoded from the P gene and binds a number of host proteins to regulate signalling pathways.
Sofiya Tsimbalyuk, Emily Cross, Mikayla Hoad, Camilla Donnelly, Justin Roby, Jade Forwood   +5 more
openaire   +3 more sources

Cedar virus biology and its applications as a surrogate for highly pathogenic henipaviruses

Cell Insight
Nipah Virus (NiV) and Hendra Virus (HeV), are the prototype species of the genus Henipavirus and are highly pathogenic agents capable of causing fatal diseases in both animals and humans.
Ahmad Jawad Sabir, Lijun Rong, Christopher C. Broder, Moushimi Amaya   +3 more
doaj   +1 more source

HenipavirusInfection in Fruit Bats (Pteropus giganteus), India

Emerging Infectious Diseases, 2008
(Uploaded by Plazi for the Bat Literature Project) We tested 41 bats for antibodies against Nipah and Hendra viruses to determine whether henipaviruses circulate in pteropid fruit bats (Pteropus giganteus) in northern India. Twenty bats were seropositive for Nipah virus, which suggests circulation in this species, thereby extending the known ...
Epstein, Jonathan H., Prakash, Vibhu, Smith, Craig S., Daszak, Peter, McLaughlin, Amanda B., Meehan, Greer, Field, Hume E., Cunningham, Andrew A.   +7 more
openaire   +4 more sources