Results 51 to 60 of about 3,651 (163)

Recent developments in experimental animal models ofHenipavirusinfection [PDF]

Pathogens and Disease, 2014
Hendra (HeV) and Nipah (NiV) viruses (genus Henipavirus (HNV; family Paramyxoviridae) are emerging zoonotic agents that can cause severe respiratory distress and acute encephalitis in humans. Given the lack of effective therapeutics and vaccines for human use, these viruses are considered as public health concerns. Several experimental animal models of
openaire   +2 more sources

Inhibition of Henipavirus fusion and infection by heptad-derived peptides of the Nipah virus fusion glycoprotein [PDF]

Virology Journal, 2005
Abstract Background The recent emergence of four new members of the paramyxovirus family has heightened the awareness of and re-energized research on new and emerging diseases. In particular, the high mortality and person to person transmission associated with the most recent Nipah virus outbreaks, as well as the very
Eaton Bryan T, Wang Lin-Fa, Crameri Gary, Mungall Bruce A, Bossart Katharine N, Broder Christopher C   +5 more
openaire   +3 more sources

Enzyme-Linked Immunosorbent Assay Using Henipavirus-Receptor EphrinB2 and Monoclonal Antibodies for Detecting Nipah and Hendra Viruses

Viruses
The Nipah virus (NiV) and the Hendra virus (HeV) are highly pathogenic zoonotic diseases that can cause fatal infections in humans and animals. Early detection is critical for the control of NiV and HeV infections.
Wenjun Zhu, Greg Smith, Bradley Pickering, Logan Banadyga, Ming Yang   +4 more
doaj   +1 more source

Potent Cross‐neutralizing Antibodies Reveal Vulnerabilities of Henipavirus Fusion Glycoprotein

Advanced Science, Volume 12, Issue 27, July 17, 2025.
Hendra and Nipah viruses (HNVs) pose significant threats to global health. This work reports potent cross‐neutralizing antibodies targeting the fusion glycoprotein (F) and reveals shared features of these antibodies and vulnerabilities of F, thereby guiding the rational design of countermeasures against HNVs and similar pathogens.
Yi Ren, Pengfei Fan, Xinghai Zhang, Ting Fang, Zhengshan Chen, Yanfeng Yao, Xiangyang Chi, Guanying Zhang, Xiaofan Zhao, Bingjie Sun, Fangxu Li, Zixuan Liu, Zhenwei Song, Baoyue Zhang, Cheng Peng, Entao Li, Yilong Yang, Jianmin Li, Sandra Chiu, Changming Yu   +19 more
wiley   +1 more source

Recombinant vesicular stomatitis virus–vectored vaccine induces long-lasting immunity against Nipah virus disease

The Journal of Clinical Investigation, 2023
The emergence of the novel henipavirus, Langya virus, received global attention after the virus sickened over three dozen people in China. There is heightened concern that henipaviruses, as respiratory pathogens, could spark another pandemic, most ...
Courtney Woolsey, Viktoriya Borisevich, Alyssa C. Fears, Krystle N. Agans, Daniel J. Deer, Abhishek N. Prasad, Rachel O’Toole, Stephanie L. Foster, Natalie S. Dobias, Joan B. Geisbert, Karla A. Fenton, Robert W. Cross, Thomas W. Geisbert   +12 more
doaj   +1 more source

Land Use Change and Infectious Disease Emergence

Reviews of Geophysics, Volume 63, Issue 2, June 2025.
Abstract Major infectious diseases threatening human health are transmitted to people from animals or by arthropod vectors such as insects. In recent decades, disease outbreaks have become more common, especially in tropical regions, including new and emerging infections that were previously undetected or unknown. Even though there is growing awareness
M. Cristina Rulli, Paolo D’Odorico, Nikolas Galli, Reju S. John, Renata L. Muylaert, Monia Santini, David T. S. Hayman   +6 more
wiley   +1 more source

A conserved motif in Henipavirus P/V/W proteins drives the fibrillation of the W protein from Hendra virus

Protein Science, Volume 34, Issue 4, April 2025.
Abstract The Hendra (HeV) and Nipah (NiV) viruses are high‐priority, biosafety level‐4 pathogens that cause fatal neurological and respiratory disease. Their P gene encodes not only the P protein, an essential polymerase cofactor, but also the virulence factors V and W.
Frank Gondelaud, Christophe Bignon, Denis Ptchelkine, Frédéric Carrière, Sonia Longhi   +4 more
wiley   +1 more source

Fc-Based Recombinant Henipavirus Vaccines Elicit Broad Neutralizing Antibody Responses in Mice

Viruses, 2020
The genus Henipavirus (HNVs) includes two fatal viruses, namely Nipah virus (NiV) and Hendra virus (HeV). Since 1994, NiV and HeV have been endemic to the Asia–Pacific region and responsible for more than 600 cases of infections. Two emerging HNVs, Ghana
Yaohui Li, Ruihua Li, Meirong Wang, Yujiao Liu, Ying Yin, Xiaodong Zai, Xiaohong Song, Yi Chen, Junjie Xu, Wei Chen   +9 more
doaj   +1 more source

Unraveling the molecular grammar and the structural transitions underlying the fibrillation of a viral fibrillogenic domain

Protein Science, Volume 34, Issue 3, March 2025.
Abstract Hendra virus (HeV) is a biosafety level 4 human pathogen belonging to the Henipavirus genus within the Paramyxoviridae family. In HeV, the phosphoprotein‐encoding gene also drives the synthesis of the V and W proteins that are two major players in the host innate immune response evasion.
Frank Gondelaud, Julien Leval, Lisha Arora, Anuja Walimbe, Christophe Bignon, Denis Ptchelkine, Stefania Brocca, Samrat Mukhopadyay, Sonia Longhi   +8 more
wiley   +1 more source

Emerging Nipah Virus With Pandemic Potential and High Mortality Rates: Is the Scientific Community Learning From Former Pandemics?

Reviews in Medical Virology, Volume 35, Issue 2, March 2025.
ABSTRACT As Nipah virus (NiV) infection is characterised by a possible pandemic risk, being currently limited to a small but deadly belt, the attention of other countries is essential. It has often been pointed out that NiV is an under‐researched virus with a high‐risk potential. This study aimed to show the global research history and status quo based
Doris Klingelhöfer, Markus Braun, Christina A. Naser, Dörthe Brüggmann, David A. Groneberg   +4 more
wiley   +1 more source