Results 111 to 120 of about 50,719 (280)

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Synthesis, physicochemical characterization and biological evaluation of chitosan sulfate as heparan sulfate mimics

, 2018
Despite the relevant biological functions of heparan sulfate (HS) glycosaminoglycans, their limited availability and the chemical heterogeneity from natural sources hamper their use for biomedical applications.
Heras Caballero, Ángeles María, Revuelta Crespo, Julia, Civera Tejuca, María Concepción, Garrido Fernández, Leoncio, Fernández Mayoralas, Alfonso, Bastida Codina, Agatha, Doncel Pérez, Ernesto, Acosta Contreras, Florentina Niuris, Aranaz Corral, Inmaculada, Camacho Toledano, Celia, García Junceda, Eduardo   +10 more
core   +1 more source

RNF13 is a previously undescribed interactor of iduronate 2‐sulfatase that modifies its glycosylation and maturation

The FEBS Journal, EarlyView.
Iduronate 2‐sulfatase (IDS; purple) is expressed as a precursor protein that goes through multiple steps of maturation, modification, and trafficking to become an active lysosomal enzyme that degrades glycosaminoglycans. Our study shows that the transmembrane ubiquitin ligases RNF13 (orange) and RNF167 (pink) heterodimerize, affecting IDS intracellular
Valérie C. Cabana, Antoine Y. Bouchard, Audrey M. Sénécal, Laurent Cappadocia, Marc P. Lussier   +4 more
wiley   +1 more source

Introduction to the Molecules Special Edition Entitled ‘Heparan Sulfate and Heparin: Challenges and Controversies’: Some Outstanding Questions in Heparan Sulfate and Heparin Research

Molecules, 2019
The scope of this article is to provide a brief general introduction to heparan sulfate (HS) and heparin, and attempt to identify some of the central challenges regarding research into the chemistry and biology of glycosaminoglycans (GAGs), some of which
Edwin A Yates, John T Gallagher, Marco Guerrini   +2 more
doaj   +1 more source

An NMR and molecular modelling study on the solution conformation of Heparan Sulphate: new insights into the relationship between structure and function

, 2007
A deeper insight into the structural biology of HS is key to understanding its nearuniversal functional role as a co-receptor for growth factors and morphogens.
Murphy, K.J.
core  

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor

, 2017
Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL).
Anika Reinhardt, Vilstrup, Joachim, Reinhardt, Anika, Reinhardt, Anika,, Larsen, Torben,, Wellner, Niels, Li, Jin-Ping, Lund, S., Peder Madsen, Olsen, D., Reinhardt, A., Madsen, P., Niels Wellner, Olsen, Ditte, Christian B. F. Andersen, Søren Thirup, Andersen, Christian B. F.,, Weyer, Kathrin, Madsen, Peder, Seeberger, P., Wellner, Niels,, Wellner, N., Lund, Signe,, Joachim Vilstrup, Li, J., Weyer, Kathrin,, Glerup, S., Simon Glerup, Olsen, Ditte,, Signe Lund, Kathrin Weyer, Glerup, Simon, Glerup, Simon,, Andersen, C., Gustafsen, Camilla, Seeberger, Peter H.,, Peter H. Seeberger, Torben Larsen, Camilla Gustafsen, Ditte Olsen, Thirup, Soren,, Seeberger, Peter H., Gustafsen, C., Gustafsen, Camilla,, Vilstrup, J., Larsen, T., Thirup, S., Madsen, Peder,, Vilstrup, Joachim,, Weyer, K., Andersen, Christian B. F., Lund, Signe, Jin-ping Li, Li, Jin-Ping,, Thirup, Soren, Larsen, Torben   +55 more
core   +1 more source

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

The heparanome—The enigma of encoding and decoding heparan sulfate sulfation

Journal of Biotechnology, 2007
Heparan sulfate (HS) is a cell surface carbohydrate polymer modified with sulfate moieties whose highly ordered composition is central to directing specific cell signaling events. The ability of the cell to generate these information rich glycans with such specificity has opened up a new field of "heparanomics" which seeks to understand the systems ...
Lamanna, William C., Kalus, Ina, Padva, Michael, Baldwin, Rebecca J., Merry, Catherine L. R., Dierks, Thomas   +5 more
openaire   +4 more sources

Heparan sulfate in human cutaneous Meissner's and Pacinian corpuscles

, 2020
Heparan sulfate proteoglycans are pericellular/cell surface molecules involved in somatosensory axon guidance in the peripheral nervous system. However, the distribution of heparan sulfate proteoglycans in the extracellular matrix of human cutaneous ...
Cobo R., García-Mesa Y., García-Fernandez B., Quirós L.M., Feito J., García-Suárez O., Vega J.A., Martín-Biedma B., García-Piqueras J.   +8 more
core   +1 more source