Results 101 to 110 of about 211,407 (207)

Mass Spectrometry Insights Into Post‐Translational Modifications in Extracellular Vesicles

Mass Spectrometry Reviews, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are membrane‐enclosed structures secreted by virtually all living cells, serving as essential mediators of intercellular communication in both physiological and pathological processes. There is growing interest in their potential applications as biomarkers, therapeutic targets, and drug delivery systems, which ...
Dávid Virág, Krisztián Márk Karvaly, Alexandra Molnár, Mirjam Balbisi, Júlia Németh, Lilla Turiák   +5 more
wiley   +1 more source

Alternative signaling pathways triggered by different mechanisms of serpin endocytosis [PDF]

, 2006
Protease Nexin-1 (PN-1), a 43 KDa glycoprotein, is known as a serpin (serine protease inhibitor) regulating extracellular proteolytic activity. It strongly inhibits the activity of several serine proteases such as thrombin, tissue plasminogen activator ...
Li, Xiaobiao
core   +1 more source

Organoid Coculture Models for Cancer Research and Immunotherapy

Med Research, EarlyView.
This review summarizes organoid coculture platforms, including submerged Matrigel culture, air–liquid interface, microfluidic/organoid‐on‐a‐chip, and 3D bioprinting, for reconstructing the tumor microenvironment to study tumor–stroma/immune crosstalk, evaluate immunotherapies, and enable drug screening.
Zhuo Yang, Huihui Yang, Guangxin Li, Guobang Liu, Zhulan Chen, Wenzhi Tian, Meiyang Huang, Xiaoling Liu, Yongsheng Zhao, Dong Chen   +9 more
wiley   +1 more source

Heparan sulfate mimetics can efficiently mobilize long-term hematopoietic stem cells

Haematologica, 2012
Background Although mobilization of hematopoietic stem cells and hematopoietic progenitor cells can be achieved with a combination of granulocyte colony-stimulating factor and plerixafor (AMD3100), improving approaches for hematopoietic progenitor cell ...
Fabio Di Giacomo, Daniel Lewandowski, Eric Cabannes, Vanessa Nancy-Portebois, Maurice Petitou, Serge Fichelson, Paul-Henri Romeo   +6 more
doaj   +1 more source

Inhibition of Plasmodium falciparum growth in vitro and adhesion to chondroitin-4-sulfate by the heparan sulfate mimetic PI-88 and other sulfated oligosaccharides [PDF]

, 2006
A panel of sulfated oligosaccharides was tested for antimalarial activity and inhibition of adhesion to the placental malaria receptor chondroitin-4-sulfate (CSA).
Andrews, K.T., Schwartz-Albiez, Reinhard, Ferro, Vito, Adams, Yvonne, Schwartz-Albiez, R., Freeman, C., Parish, C.R., Ferro, V., Parish, Christopher, Parish, Christopher R., Adams, Y., Andrews, Katherine, Freeman, Craig, Parish, Christopher R, Andrews, Katherine T., Andrews, Katherine T   +15 more
core   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Heparan sulfate proteoglycans present PCSK9 to the LDL receptor [PDF]

, 2017
Coronary artery disease is the main cause of death worldwide and accelerated by increased plasma levels of cholesterol-rich low-density lipoprotein particles (LDL).
Anika Reinhardt, Vilstrup, Joachim, Reinhardt, Anika, Reinhardt, Anika,, Larsen, Torben,, Wellner, Niels, Li, Jin-Ping, Lund, S., Peder Madsen, Olsen, D., Reinhardt, A., Madsen, P., Niels Wellner, Olsen, Ditte, Christian B. F. Andersen, Søren Thirup, Andersen, Christian B. F.,, Weyer, Kathrin, Madsen, Peder, Seeberger, P., Wellner, Niels,, Wellner, N., Lund, Signe,, Joachim Vilstrup, Li, J., Weyer, Kathrin,, Glerup, S., Simon Glerup, Olsen, Ditte,, Signe Lund, Kathrin Weyer, Glerup, Simon, Glerup, Simon,, Andersen, C., Gustafsen, Camilla, Seeberger, Peter H.,, Peter H. Seeberger, Torben Larsen, Camilla Gustafsen, Ditte Olsen, Thirup, Soren,, Seeberger, Peter H., Gustafsen, C., Gustafsen, Camilla,, Vilstrup, J., Larsen, T., Thirup, S., Madsen, Peder,, Vilstrup, Joachim,, Weyer, K., Andersen, Christian B. F., Lund, Signe, Jin-ping Li, Li, Jin-Ping,, Thirup, Soren, Larsen, Torben   +55 more
core   +1 more source

The FGF/FGFR System in the Biology and Therapeutic Landscape of Pediatric CNS Tumors

Medicinal Research Reviews, EarlyView.
ABSTRACT Central nervous system (CNS) tumors are the most common solid malignancies in children, comprising a highly heterogeneous group of neoplasms defined by distinct molecular alterations and clinical behaviors. Advances in molecular genetics have underscored the relevance of specific signaling pathways in driving pediatric tumorigenesis, among ...
Serena Filiberti, Camilla Tavani, Elena Somenza, Nicolas Tassone, Antonio d'Amati, Marta Turati, Roberto Ronca   +6 more
wiley   +1 more source

AGRN‐, LRP4‐, MUSK‐Related CMS: Clinical, Neurophysiological, Morphological, Genetic and Pathological Mechanisms

Muscle &Nerve, EarlyView.
ABSTRACT Congenital myasthenic syndromes (CMS) are inherited disorders caused by mutations in genes encoding proteins essential for neuromuscular junction (NMJ) function. Pathogenic variants have been identified in more than 35 genes, underscoring the complexity of synaptic biology and the wide range of mechanisms that can compromise neuromuscular ...
Rocio‐Nur Villar‐Quiles, Damien Sternberg, Marie‐Christine Nougues, Arnaud Isapof, Bruno Eymard, Stéphanie Bauché   +5 more
wiley   +1 more source

Heparan Sulfate Identification and Characterisation: Method I. Heparan Sulfate Identification by NMR Analysis

Bio-Protocol, 2017
Heparin and heparan sulfate (HS) may be purified from complex biological matrices and are often isolated in sub-milligram quantities but not unequivocally identified by spectroscopic means.
Susan Carnachan, Simon F.R. Hinkley
doaj   +1 more source