Results 81 to 90 of about 79,508 (247)

Recent Advances in Virus–Host Interactions, Antiviral Bioactive Compounds, and Breeding for Disease Resistance of Porcine Epidemic Diarrhea Virus

Animal Research and One Health, EarlyView.
Basic research on the PEDV infection cycle and virus–host interactions advances the development of anti‐PEDV drugs and disease‐resistant breeding and helps strengthen disease prevention and control while reducing economic losses in the swine industry.
Heyong Wu, Aosi Qi, Shuyu Zhong, Haozhen Du, Shimeng Guo, Hongsheng Ouyang, Hongming Yuan, Daxin Pang, Zicong Xie   +8 more
wiley   +1 more source

Heparin and Heparan Sulfate Biosynthesis [PDF]

IUBMB Life, 2002
AbstractHeparan sulfate is one of the most informationally rich biopolymers in Nature. Its simple sugar backbone is variously modified to different degrees depending on the cellular conditions. Thus, it matures to have an enormously complicated structure, which most likely exhibits a considerable number of unique overlapping sequences with peculiar ...
Kazuyuki, Sugahara, Hiroshi, Kitagawa
openaire   +2 more sources

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Endothelial Heparan Sulfate in Angiogenesis [PDF]

, 2010
Heparan sulfate (HS) is a linear polysaccharide composed of 50-200 glucosamine and uronic acid (glucuronic acid or iduronic acid) disaccharide repeats with epimerization and various sulfation modifications. HS is covalently attached to core proteins to form HS-proteoglycans.
Mark M, Fuster, Lianchun, Wang
openaire   +2 more sources

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, EarlyView.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

Heparan sulfate proteoglycans and cancer [PDF]

British Journal of Cancer, 2001
Heparan sulfate proteoglycans (HSPGs) are widely distributed in mammalian tissues and involved in a number of processes related to malignancy. They are composed of a core protein to which chains of the glycosaminoglycan, heparan sulfate (HS), are attached.
Blackhall, F. H., Merry, C. L R, Davies, E. J., Jayson, G. C.   +3 more
openaire   +2 more sources

A monoclonal antibody against a laminin-heparan sulfate proteoglycan complex perturbs cranial neural crest migration in vivo [PDF]

, 1988
INO (inhibitor of neurite outgrowth) is a monoclonal antibody that blocks axon outgrowth, presumably by functionally blocking a laminin-heparan sulfate proteoglycan complex (Chiu, A. Y., W. D. Matthew, and P. H. Patterson. 1986. J. Cell Biol.
Bronner-Fraser, Marianne, Lallier, Thomas   +1 more
core   +2 more sources

Controlled Triazine‐Based Covalent Functionalization of Black Phosphorus for Degradable Hybrid Materials

Small, EarlyView.
A scalable triazine‐based covalent functionalization strategy of black phosphorus nanosheets provides controlled P‐N surface chemistry with enhanced grafting density in the presence of a phase‐transfer catalyst. As a representative example, BP‐sulfated polymer conjugates exhibit strong in vitro antiviral activity against enveloped viruses and ...
Jasmin Er, Sreejita Ray, Enyu Xie, Robert Schusterbauer, Maik Rosentreter, Ranen Etouki, Na Xing, Anja Wiesner, Philip Nickl, Rameez Ahmed, Taylor Page, Ana Hočevar, Obida Bawadkji, Andreas Herrmann, Jörg Radnik, Vasile‐Dan Hodoroaba, Christian Sieben, Beate Paulus, Ievgen S. Donskyi   +18 more
wiley   +1 more source

Heparan sulfate-protein binding specificity [PDF]

Biochemistry (Moscow), 2013
Heparan sulfate (HS) represents a large class of linear polysaccharides that are required for the function of all mammalian physiological systems. HS is characterized by a repeating disaccharide backbone that is subject to a wide range of modifications, making this class of macromolecules arguably the most information dense in all of biology.
M A, Nugent, J, Zaia, J L, Spencer
openaire   +2 more sources