Results 81 to 90 of about 50,719 (280)
Heparan sulfate biosynthesis enzymes EXT1 and EXT2 affect NDST1 expression and heparan sulfate sulfation [PDF]
Proceedings of the National Academy of Sciences, 2008 Heparan sulfate (HS) proteoglycans influence embryonic development and adult physiology through interactions with protein ligands. The interactions depend on HS structure, which is determined largely during biosynthesis by Golgi enzymes. How biosynthesis is regulated is more or less unknown.
Jenny, Presto +7 more
openaire +2 more sources
Alternative signaling pathways triggered by different mechanisms of serpin endocytosis [PDF]
, 2006 Protease Nexin-1 (PN-1), a 43 KDa glycoprotein, is known as a serpin (serine protease inhibitor) regulating extracellular proteolytic activity. It strongly inhibits the activity of several serine proteases such as thrombin, tissue plasminogen activator ...
Li, Xiaobiao
core +1 more source
The Journal of Pathology, EarlyView.Abstract Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related deaths globally, and cases are predicted to rise dramatically over the next few years. Overcoming the immune microenvironment in HCC remains a challenge, and innate immune populations such as tumour‐associated neutrophils can potentially impair the success of immunotherapy ...
Joanne M O'Rourke +24 more
wiley +1 more source
Heparan sulfates and heparins: similar compounds performing the same functions in vertebrates and invertebrates? [PDF]
Brazilian Journal of Medical and Biological Research, 1999 The distribution and structure of heparan sulfate and heparin are briefly reviewed. Heparan sulfate is a ubiquitous compound of animal cells whose structure has been maintained throughout evolution, showing an enormous variability regarding the relative ...
H.B. Nader +14 more
doaj +1 more source
Allergy, EarlyView.ABSTRACT This update and revision of the international guideline for urticaria was developed in accordance with the methods recommended by Cochrane and the Grading of Recommendations Assessment, Development and Evaluation (GRADE) working group. It is an initiative of the Global Allergy and Asthma Excellence Network (GA2LEN) and its Urticaria and ...
T. Zuberbier +221 more
wiley +1 more source
Keratinocyte Priming by Staphylococcus aureus Reduces HSV‐1 Susceptibility
Allergy, EarlyView.ADEH+ patients have a reduced microbial diversity with increased S. aureus and S. epidermidis colonization compared to ADEH− and healthy controls. Heat‐killed S. aureus reduced HSV‐1 susceptibility and release of infectious progeny virus in a keratinocyte in vitro model. Heat‐killed S.
Phila Cara Baumann +19 more
wiley +1 more source
Scientific Reports, 2017 Amyloid aggregates found in the brain of patients with neurodegenerative diseases, including Alzheimer’s and Parkinson’s disease, are thought to spread to increasingly larger areas of the brain through a prion-like seeding mechanism.
Elisabet Ihse +5 more
doaj +1 more source
The Sea as a Rich Source of Structurally Unique Glycosaminoglycans and Mimetics
Microorganisms, 2017 Glycosaminoglycans (GAGs) are sulfated glycans capable of regulating various biological and medical functions. Heparin, heparan sulfate, chondroitin sulfate, dermatan sulfate, keratan sulfate and hyaluronan are the principal classes of GAGs found in ...
Ariana A. Vasconcelos, Vitor H. Pomin
doaj +1 more source
, 2011 Heparin (Hep), a highly sulfated and complex glycosaminoglycan polysaccharides, is worldwide used as an anticoagulant compound to prevent blood clotting during surgery.
Chavaroche, A.A.E.
core
Structural characterization of human liver heparan sulfate
, 2005 The isolation, purification and structural characterization of human liver heparan sulfate are described. H-1-NMR spectroscopy demonstrates the purity of this glycosaminoglycan (GAG) and two-dimensional H-1-NMR confirmed that it was heparan sulfate ...
Toida, T +11 more
core +1 more source