Results 71 to 80 of about 79,508 (247)
Intravenous fluid resuscitation is associated with septic endothelial glycocalyx degradation
Critical Care, 2019 Background Intravenous fluids, an essential component of sepsis resuscitation, may paradoxically worsen outcomes by exacerbating endothelial injury.
Joseph A. Hippensteel +14 more
doaj +1 more source
Frontiers in Immunology, 2021 While human leukocyte antigen (HLA) and HLA-like proteins comprise an overwhelming majority of known ligands for NK-cell receptors, the interactions of NK-cell receptors with non-conventional ligands, particularly carbohydrate antigens, is less well ...
Klara Klein +16 more
doaj +1 more source
Advanced Science, EarlyView.Ovarian macrophage depletion reverses OHSS resistance in estrildid finches and exacerbates OHSS symptoms in rats. Activating macrophage GPR183 alleviates OHSS by reducing pro‐inflammatory factors, increasing immunomodulatory molecules, remodeling CD44/SDC4‐mediated communication, and restoring immune homeostasis.
Xiaofei Yan +11 more
wiley +1 more source
Heparan Sulfate Polymerization in Drosophila [PDF]
Journal of Biological Chemistry, 2006 The formation of heparan sulfate (HS) chains is catalyzed by glycosyltransferases encoded by EXT (hereditary multiple exostosin gene) family members. Genetic screening for mutations affecting morphogen signaling pathways in Drosophila has identified three genes, tout-velu (ttv), sister of tout-velu (sotv), and brother of toutvelu (botv), which encode ...
Tomomi, Izumikawa +4 more
openaire +2 more sources
Cellular Physiology and Biochemistry, 2018 Background/Aims: The up-regulation of hepatocyte growth factor/receptor, HGF/Met, signal transduction is observed in most of human cancers. Specific heparan sulfate structures enhance the HGF/Met signaling at both cell and animal-based model systems ...
Tong Cao +11 more
doaj +1 more source
Basement membrane proteoglycans: modulators Par Excellence of cancer growth and angiogenesis. [PDF]
, 2009 Proteoglycans located in basement membranes, the nanostructures underling epithelial and endothelial layers, are unique in several respects. They are usually large, elongated molecules with a collage of domains that share structural and functional ...
Iozzo, Renato V +2 more
core +2 more sources
American Journal of Medical Genetics Part A, EarlyView.ABSTRACT Since 2015, Ann and Robert H. Lurie Children's Hospital has performed diagnostic testing for infants who screen positive for mucopolysaccharidosis type II (MPS II) on the Illinois newborn screen. Preliminary diagnostic testing includes measurement of plasma iduronate‐2‐sulfatase enzyme activity and urinary glycosaminoglycan analysis, followed ...
Carly A. Rasmussen +5 more
wiley +1 more source
Heparan Sulfate Biosynthesis in Zebrafish [PDF]
Journal of Histochemistry & Cytochemistry, 2020 The biosynthesis of heparan sulfate (HS) proteoglycans occurs in the Golgi compartment of cells and will determine the sulfation pattern of HS chains, which in turn will have a large impact on the biological activity of the proteoglycans. Earlier studies in mice have demonstrated the importance of HS for embryonic development.
Filipek-Górniok B +3 more
openaire +3 more sources
Cell-to-cell transmission of p53 aggregates: a novel player in oncology?
Molecular & Cellular Oncology, 2021 The mutants of the tumor suppressor protein p53 form protein aggregates. It has been proposed that these aggregates propagate like prions, albeit the detailed mechanism of the propagation is unclear.
Naoyuki Iwahashi +4 more
doaj +1 more source
Agrin binds to the nerve-muscle basal lamina via laminin [PDF]
, 1997 Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Altschul +73 more
core +3 more sources