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Demystifying Heparan Sulfate–Protein Interactions [PDF]
Annual Review of Biochemistry, 2014 Numerous proteins, including cytokines and chemokines, enzymes and enzyme inhibitors, extracellular matrix proteins, and membrane receptors, bind heparin.
Ding Xu, Jeffrey D Esko
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Chemoenzymatic Design of Heparan Sulfate Oligosaccharides*
Journal of Biological Chemistry, 2010 Heparan sulfate is a sulfated glycan that exhibits essential physiological functions. Interrogation of the specificity of heparan sulfate-mediated activities demands a library of structurally defined oligosaccharides.
R Liu, Yongmei Xu, Michel Weiwer
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A Systems View of the Heparan Sulfate Interactome [PDF]
Journal of Histochemistry and Cytochemistry, 2021 Heparan sulfate proteoglycans consist of a small family of proteins decorated with one or more covalently attached heparan sulfate glycosaminoglycan chains.
Alejandro Gomez Toledo +2 more
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The heparitin sulfates (heparan sulfates)
Carbohydrate Research, 1973Heparitin sulfate has been isolated from several sources, namely: a commercial lung polysaccharide preparation, beef lung, beef aorta, human amyloid liver, human intestine, and urine of a patient with mucopolysaccharidosis. The polysaccharides isolated were extensively purified, fractionated, and characterized.
A, Linker, P, Hovingh
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The heparan sulfate of rat brain
Biochimica et Biophysica Acta (BBA) - General Subjects, 1972Heparan sulfate comprises 14% of the total mucopolysaccharide content of rat brain. Two heparan sulfate fractions (HS-I and HS-II) can be obtained by gradient elution from Dowex I (chloride). HS-I is eluted with i.o. M NaCl and accounts for approximately one third of the total heparan sulfate, while HS-II, accounting for the remaining two thirds of the
R U, Margolis, D M, Atherton
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Heparan sulfate: a piece of information
The FASEB Journal, 1996The sulfated glycosaminoglycans, heparan sulfate and heparin, are increasingly implicated in cell‐biological processes such as cytokine action, cell adhesion, and regulation of enzymic catalysis. These activities generally depend on interactions of the polysaccharides with proteins, mediated by distinct saccharide sequences, and ...
M, Salmivirta, K, Lidholt, U, Lindahl
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Heparan Sulfate Proteoglycans in Diabetes
Seminars in Thrombosis and Hemostasis, 2021AbstractDiabetes is a complex disorder responsible for the mortality and morbidity of millions of individuals worldwide. Although many approaches have been used to understand and treat diabetes, the role of proteoglycans, in particular heparan sulfate proteoglycans (HSPGs), has only recently received attention.
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Antithrombin, heparin, and heparan sulfate
Critical Care Medicine, 2002To review the experimental and clinical evidence that antithrombin has multiple mechanisms for both its anticoagulant and anti-inflammatory properties. The interaction between antithrombin and specific polysulfated, acidic oligosaccharide moieties found on heparin and related proteoglycan molecules within the circulation and on endothelial surfaces ...
Steven M, Opal +3 more
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Biological Activities of Heparan Sulfate
2014Heparan sulfate was isolated from two bivalve mollusks such as Tridacna maxima and Perna viridis. The isolated heparin was quantified in crude as well as purified samples and they were estimated as 2.72 and 2.2g/kg (crude) and 260 and 248 mg/g (purified) in T. maxima and P. viridis, respectively.
Muthuvel, Arumugam, Sadhasivam, Giji
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Heparan Sulfate in the Tumor Microenvironment
2020The biology of tumor cells strictly depends on their microenvironment architecture and composition, which controls the availability of growth factors and signaling molecules. Thus, the network of glycosaminoglycans, proteoglycans, and proteins known as extracellular matrix (ECM) that surrounds the cells plays a central role in the regulation of tumor ...
Barbara, Bartolini +8 more
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