Alterations in heparan sulfate proteoglycan synthesis and sulfation and the impact on vascular endothelial function [PDF]
Matrix Biology Plus, 2022 The glycocalyx attached to the apical surface of vascular endothelial cells is a rich network of proteoglycans, glycosaminoglycans, and glycoproteins with instrumental roles in vascular homeostasis.
Danielle Pretorius +4 more
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Dysregulated heparan sulfate proteoglycan metabolism promotes Ewing sarcoma tumor growth [PDF]
eLife, 2022 The Ewing sarcoma family of tumors is a group of malignant small round blue cell tumors (SRBCTs) that affect children, adolescents, and young adults.
Elena Vasileva +3 more
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Heparan Sulfate Proteoglycan Clustering in Wnt Signaling and Dispersal [PDF]
Frontiers in Cell and Developmental Biology, 2020 Wnt, a family of secreted signal proteins, serves diverse functions in animal development, stem cell systems, and carcinogenesis. Although Wnt is generally considered a morphogen, the mechanism by which Wnt ligands disperse is still debated.
Yusuke Mii +6 more
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Effect of epithelial debridement on human cornea proteoglycans [PDF]
Brazilian Journal of Medical and Biological Research, 2001 Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural
E.S. Soriano +3 more
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Therapeutic development targeting host heparan sulfate proteoglycan in SARS-CoV-2 infection [PDF]
Frontiers in MedicineThe global pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to an urgent need for effective therapeutic options.
Qi Zhang +3 more
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Heparan sulfate proteoglycans undergo differential expression alterations in left sided colorectal cancer, depending on their metastatic character [PDF]
BMC Cancer, 2018 Background Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells.
Ainara Crespo +6 more
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Unraveling Heparan Sulfate Proteoglycan Binding Motif for Cancer Cell Selectivity [PDF]
Frontiers in Oncology, 2019 Membrane heparan sulfate proteoglycans (HSPG) regulate cell proliferation, migration, and differentiation and are therefore considered key players in cancer cell development processes.
Jlenia Brunetti +9 more
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Heparan Sulfate Proteoglycan Is an Important Attachment Factor for Cell Entry of Akabane and Schmallenberg Viruses. [PDF]
J Virol, 2017 Akabane (AKAV) and Schmallenberg (SBV) viruses are Orthobunyavirus transmitted by arthropod vectors with a broad cellular tropism in vitro as well as in vivo Both AKAV and SBV cause arthrogryposis-hydranencephaly syndrome in ruminants.
Murakami S +6 more
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Interaction of poly-L-lysine coating and heparan sulfate proteoglycan on magnetic nanoparticle uptake by tumor cells [PDF]
International Journal of Nanomedicine, 2018 Wei Xiong Siow,1,2 Yi-Ting Chang,1,2 Michal Babič,3 Yi-Ching Lu,2 Daniel Horák,3 Yunn-Hwa Ma1,2,4 1Graduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Guishan, Taoyuan, Taiwan, Republic of China; 2Department of ...
Siow WX +5 more
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Cell Density-Dependent Suppression of Perlecan and Biglycan Expression by Gold Nanocluster in Vascular Endothelial Cells [PDF]
CellsProteoglycans are macromolecules consisting of a core protein and one or more glycosaminoglycan side chains. Proteoglycans synthesized by vascular endothelial cells modulate various functions such as anticoagulant activity and vascular permeability.
Takato Hara +5 more
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