Results 121 to 130 of about 30,138 (217)
Noncrystalline uric acid inhibits proteoglycan and glycosaminoglycan synthesis in distal tubular epithelial cells (MDCK) [PDF]
, 2010 Hyperuricemia is associated with renal stones, not only consisting of uric acid (UrAc) but also of calcium oxalate (CaOx). Glycosaminoglycans (GAGs) are well-known inhibitors of growth and aggregation of CaOx crystals.
Borges, Fernanda Teixeira +3 more
core +2 more sources
The FEBS Journal, EarlyView.We describe the CD9 interactome in epithelial cells for the first time. The interactome is diverse and dynamic and changes dependent on infection with specific bacteria. We validate these data by showing functional interaction between CD9 with CD44 or CD147. We therefore demonstrate that CD9 is a universal organiser of bacterial adhesion platforms able
Paige A. Wolverson +5 more
wiley +1 more source
Lipid-Linked Heparan Sulfate Proteoglycan.
Trends in Glycoscience and Glycotechnology, 1991 ヘパラン硫酸のコアタンパク質に脂質が共有結合すると、これらの遺伝子産物と細胞膜間に新しい分子結合が出来ることになる。プロテオグリカンは糖脂質化することで細胞頂上部へのふるい分けと標的となる膜への移動を行ない、細胞表面のプロテオグリカンが酵素反応により敏速に遊離される機構が出来上がる。プロテオグリカンが脂肪酸でアシル化されることは、疎水的な相互作用と、恐らく受容体を介した結合を仲介し、細胞内のプロテオグリカン/プロテオグリカン同士の相互作用の新しい機構を提供し、代謝回転に直接的な役割を果たすかも知れない。脂質を介した繋留に必要となる微細構造上の要求性や複合的なな酵素反応装置が同定出来ると、プロテオグリカンのこの新しい翻訳後の修飾が機能的に重要であることが明らかとなるであろう。
openaire +2 more sources
The FEBS Journal, EarlyView.Irreversible ECM proteolysis by remodeling enzymes shapes development, homeostasis, and disease. ECM‐degrading proteases display cell specificity and are governed by shared mechanisms, exhibiting functional redundancy in generating matrikines, growth factors, and cytokines.
Inna Solomonov, Orit Kollet, Irit Sagi
wiley +1 more source
Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan. [PDF]
Int J Mol Sci, 2023 Provenzale I +5 more
europepmc +1 more source
Opticin Binds to Heparan and Chondroitin Sulfate Proteoglycans
Investigative Opthalmology & Visual Science, 2005 The extracellular matrix glycoprotein opticin is a small leucine-rich repeat proteoglycan/protein family member that was discovered associated with vitreous humor collagen fibrils. Opticin is present throughout the vitreous, but is particularly concentrated at the internal limiting lamina, where it colocalizes with type XVIII collagen.
Hindson, V. John +3 more
openaire +3 more sources
A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer
The FEBS Journal, EarlyView.Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou +4 more
wiley +1 more source
Galectin-14 promotes hepatocellular carcinoma tumor growth via enhancing heparan sulfate proteoglycan modification. [PDF]
J Biomed Res, 2023 Gou L +7 more
europepmc +1 more source
A homeostatic function of CXCR2 signalling in articular cartilage [PDF]
, 2014 Funding This work was funded by Arthritis Research UK (grants 17859, 17971, 19654), INNOCHEM EU FP6 (grant LSHB-CT-2005-51867), MRC (MR/K013076/1) and the William Harvey Research FoundationPeer reviewedPublisher ...
Aberdeen +17 more
core +3 more sources
Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape
The FEBS Journal, EarlyView.The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto +9 more
wiley +1 more source