Results 101 to 110 of about 250,900 (178)

Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan. [PDF]

Int J Mol Sci, 2023
Provenzale I, De Simone I, Gibbins JM, Heemskerk JWM, van der Meijden PEJ, Jones CI.   +5 more
europepmc   +1 more source

Serum Hepatocyte Growth Factor Predicts Outcomes in Non‐Acetaminophen Drug‐Induced Acute Liver Failure

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background and Aims Regenerative capacity and inflammatory responses are key determinants of outcome in acute liver failure (ALF). However, their prognostic significance in non‐acetaminophen drug‐induced liver injury with acute liver injury or ALF (non‐APAP‐DILI‐ALI/ALF) remains poorly defined.
Tao Wang, Silvia M. Bacot, Kamai Patterson, Devira Friedman, Caroline Taylor, Huixiao Hong, Jie Liu, Mark I. Avigan, Paul Hayashi, Jody A. Rule, William M. Lee, Jorge Rakela, Gerald M. Feldman, Minjun Chen   +13 more
wiley   +1 more source

Galectin-14 promotes hepatocellular carcinoma tumor growth via enhancing heparan sulfate proteoglycan modification. [PDF]

J Biomed Res, 2023
Gou L, Yang G, Ma S, Ding T, Sun L, Liu F, Huang J, Gao W.   +7 more
europepmc   +1 more source

Pancreatic Cancer Early Detection Biomarkers for High‐Risk Individuals: Insights From the PRECEDE Consortium

International Journal of Cancer, Volume 159, Issue 8, Page 1873-1883, 15 October 2026.
ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) remains one of the deadliest cancers due to its asymptomatic progression, late‐stage diagnosis, and treatment resistance. Efforts in early detection have centered on identifying imaging features and liquid biopsy biomarkers capable of detecting PDAC and its high‐grade precursors before clinical symptoms ...
Christine Worthington, Maria Raitses‐Gurevich, Giulio Innamorati, Phil A. Hart, Thomas M. Wilkie, Noam Tau, Dana Brin, Doron Yablecovitch, Ido Laish, Dove Keith, Kurt Giles, Jennifer B. Permuth, Diane M. Simeone, George Zogopoulos, Randall E. Brand, John J. Graff, Julie Earl, On behalf of the PRECEDE Consortium, Nikhil Agarwal, Laufey Amundadottir, Michelle Anderson, Ajay Bansal, Todd Bauer, Georg Beyer, Yan Bi, Erkut Borazanci, Randy Brand, Teri Brentnall, Carol Burke, Darren Carpizo, Saurabh Chawla, Daniel Chung, Sourat Darabi, Michael Demeure, Timothy Donahue, Julie Earl, Whitney Espinel, James Farrell, Vigdís Fjóla Stefánsdóttir, Jared Forrester, Eitan Friedman, Paul Franklin, Srinivas Gaddam, Ana García García de Paredes, Steven Gallinger, Talia Golan, Ora Gordon, Robert Grant, William Greenhalf, Eli Marie Grindedal, Aaron Grossberg, Brenda Hafers, Heather Hannon, Sigurdís Haraldsdóttir, Stefán Haraldsson, Peter Hegyi, Melissa Hogg, Amy de Haar‐Holleman, Susan Hong, Greg Idos, Edward Kim, Fay Kastrinos, Bryson Katona, Vivek Kaul, Derk Klatte, Kelsey Klute, Kimberly Ku, Sonia Kupfer, Rich Kwon, Rosario Ligresti, James James Lin, Wei‐Chih (David) Liao, Aimee Lucas, Nipun Merchant, Andrew Metz, Whitney Maxwell, James McLoughlin, Sodech Miclette, Xavier Molero, Leticia Moreira, Takuji Okusaka Chigusa Morizane, Joanne Ngeow, Salvatore Paiella, Jennifer Permuth, Maricel Purcell, Joshua Raff, Vineet Rolston, Intan Schrader, Rosie Sears, Yan‐Shen Shan, Diane Simeone, Jens Siveke, Brett Sheppard, Tyler Stevens, Elena Stoffel, Dan Sussman, Margaret Tempero, Jose Trevino, Jennifer Valerin, Eva Vaquero, Ray Wadlow, Garrett Ward, David Weinberg, Ronald Wolf, Dana Zakalik, George Zogopoulos   +105 more
wiley   +1 more source

Endothelial Exostosin‐1 Is Needed for Glycocalyx Integrity and Inflammatory Resolution in Acute Lung Injury

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Endothelial Ext1 is essential for maintaining heparan sulfate–rich endothelial glycocalyx integrity. Loss of Ext1 reduces glycocalyx thickness, resulting in enhanced leukocyte adhesion, increased vascular permeability, and exaggerated inflammatory responses following lipopolysaccharide (LPS) challenge.
Yuki Kawasaki, Hiroyuki Tomita, Kodai Suzuki, Chihiro Takada, Hirotaka Asano, Soichiro Kano, Yugo Wakayama, Hirotsugu Fukuda, Toru Minamiyama, Genki Yoshimura, Ryo Kamidani, Yoshinori Kakino, Tomotaka Miura, Yuichiro Kitagawa, Tetsuya Fukuta, Takahito Miyake, Akio Suzuki, Kazu Matsumoto, Nobuyuki Tetsuka, Shozo Yoshida, Yoichi Maekawa, Yu Yamaguchi, Hideshi Okada   +22 more
wiley   +1 more source

Understanding the Role of Heparan Sulfate Proteoglycan (Hspg2) in Brain and Behavioral Development

, 2021
Heparan Sulfate Proteoglycan 2 (Hspg2) is a highly conserved gene that expresses Perlecan, an extracellular matrix protein implicated in the development of the heart, bones, and muscles.
Siribaddana, Oneli
core  

Heparan Sulfate Proteoglycan-Mediated Entry Pathway for Charged Tri-Platinum Compounds: Differential Cellular Accumulation Mechanisms for Platinum

, 2016
We examined the mechanism of accumulation of charged polynuclear platinum complexes (PPCs) based on analogy of polyarginine interactions with the cell surface heparan sulfate proteoglycan (HSPG) family of protein-linked glycosoaminoglycan polysaccharides
Heveline Silva (2078302), Frédéric Frézard (2078308), Erica J. Peterson (1792345), John J. Ryan (400670), Nicholas P. Farrell (1349007), Peyman Kabolizadeh (2078305)   +5 more
core   +1 more source

On-demand chlorine dioxide solution enhances odontoblast differentiation through desulfation of cell surface heparan sulfate proteoglycan and subsequent activation of canonical Wnt signaling. [PDF]

Front Cell Dev Biol, 2023
Inubushi T, Priyanka N, Watanabe M, Takahashi Y, Kusano S, Kurosaka H, Papagerakis S, Papagerakis P, Hayashi M, Yamashiro T.   +9 more
europepmc   +1 more source

Development of Anti‐Inflammatory Extracellular Vesicles by Surface Expression of Syndecan‐4

Journal of Extracellular Vesicles
The biological functions of extracellular vesicles (EVs) depend on their cellular source. Further, different subpopulations of EVs from the same cells carry different cargo, but differences in their biological functions are less understood.
Lijuan Yu, Markus Bergqvist, Kyong‐Su Park, Cecilia Lässer, Jan Lötvall   +4 more
doaj   +1 more source

Heterogeneity of heparan sulfate proteoglycans synthesized by PYS-2 cells

, 1984
Antibodies to the basement membrane proteoglycan produced by the EHS tumor were used to immunoprecipitate [35S]sulfate-labeled protoglycans produced by PYS-2 cells.
Hassell, John R., Horigan, Elizabeth A., Klippenstein, Donald L., Tyree, Bernadette   +3 more
core   +1 more source