Results 91 to 100 of about 28,889 (219)

The endothelial glycocalyx: composition, functions, and visualization [PDF]

, 2007
This review aims at presenting state-of-the-art knowledge on the composition and functions of the endothelial glycocalyx. The endothelial glycocalyx is a network of membrane-bound proteoglycans and glycoproteins, covering the endothelium luminally.
Sietze Reitsma, Dick W. Slaaf, Hans Vink, Marc A. M. J. van Zandvoort, Mirjam G. A. oude Egbrink, P Algenstaedt, S Ali, BL Allen, ML Ballinger, AL Barker, A Beresewicz, MC Berndt, RJ Beuk, L Bode, L Bode, T Bombeli, DJ Carey, AA Constantinescu, FR Curry, S Das, PF Davies, C Desjardins, CF Dewey Jr, VS Dole, XL Du, MG Egbrink, JD Esko, SP Evanko, JA Florian, LA Fransson, JR Fromm, JL Funderburgh, L Ghitescu, RM Gibson, M Gouverneur, N Grammatikakis, DN Granger, YF Han, GK Hansson, CB Henry, CB Henry, C Hjalmarsson, G Ho, AJ Hoogewerf, X Hu, MT Huang, VH Huxley, NS Ihrcke, RV Iozzo, M Jacob, GH Janssen, U Jung, GS Kansas, H Kato, MG Kinsella, B Klitzman, B Klitzman, JA Koedam, H Kresse, AM Kupinski, I Kurose, TC Laurent, JY Lee, Q Li, P Libby, X Lin, HH Lipowsky, HH Lipowsky, F Lopez-Casillas, JA Lopez, JH Luft, RTA Megens, CC Michel, S Mochizuki, AW Mulivor, AM Muller, A Nandi, DM Nathan, M Nieuwdorp, M Nieuwdorp, M Nieuwdorp, MG Oliver, MG oude Egbrink, JR Pappenheimer, KA Parker, KD Patel, N Perrimon, AR Pries, AR Pries, AR Pries, AR Pries, NS Quinsey, R Raman, A Rapraeger, A Rapraeger, M Rehm, CJ Robinson, R Ross, J Rostgaard, J Rostgaard, GM Rubanyi, I Rubio-Gayosso, C Ruegg, ZM Ruggeri, S Salek-Ardakani, IH Sarelius, K Sasaki, JE Scott, JE Scott, JB Seal, TW Secomb, K Shimada, M Sperandio, M Sperandio, D Spillmann, TA Springer, EH Starling, RJ Stewart, K Sugahara, L Tan, JM Tarbell, JM Tarbell, LM Title, E Tkachenko, AM Tovar, A Ueda, B Berg van den, BM Berg van den, BM Berg van den, PM Haaren van, PM Haaren van, M Zandvoort van, H Vink, H Vink, H Vink, CA Vogl-Willis, B Vollmar, CS Wang, BJ Ward, PH Weigel, H Weiler, S Weinbaum, S Weinbaum, W Weninger, LC Wilsie, G Wu, JP Xiong, K Yamashita, X Zhang, L Zhuo   +149 more
core   +1 more source

Ultraviolet irradiation induces the accumulation of chondroitin sulfate, but not other glycosaminoglycans, in human skin. [PDF]

PLoS ONE, 2011
Ultraviolet (UV) light alters cutaneous structure and function. Prior work has shown loss of dermal hyaluronan after UV-irradiation of human skin, yet UV exposure increases total glycosaminoglycan (GAG) content in mouse models.
Benjamin Boegel Werth, Muhammad Bashir, Laura Chang, Victoria P Werth   +3 more
doaj   +1 more source

Behind the scenes: how the EMILIN/Multimerin family shapes the cancer landscape

The FEBS Journal, EarlyView.
The EMILIN/Multimerin family members regulate key hallmarks of cancer—including apoptosis, angiogenesis, metastasis, and tumor microenvironment remodeling. As indicated, their function in immune evasion, drug resistance, and metabolic reprogramming remains largely unexplored.
Evelina Poletto, Naike Casagrande, Emanuele Di Siena, Greta Carobolante, Lucrezia Camicia, Giorgia Schinello, Samanta Muzzin, Enrica Timis, Paola Spessotto, Maurizio Mongiat   +9 more
wiley   +1 more source

Spatial and temporal changes in the distribution of proteoglycans during avian neural crest development [PDF]

, 1991
In this study, we describe the distribution of various classes of proteoglycans and their potential matrix ligand, hyaluronan, during neural crest development in the trunk region of the chicken embryo.
Bronner-Fraser, Marianne, Domingo, Carmen, Krotoski, Danuta, Lallier, Thomas, Perris, Roberto, Sorrell, Michael   +5 more
core  

Heparan sulfate and control of cell division: adhesion and proliferation of mutant CHO-745 cells lacking xylosyl transferase [PDF]

, 2001
We have examined the role of cell surface glycosaminoglycans in cell division: adhesion and proliferation of Chinese hamster ovary (CHO) cells.
Dietrich, Carl Peter, Franco, Celia Regina Cavichlolo, Leite, Edda Lisboa, Nader, Helena Bonciani, Rocha, Hugo Alexandre Oliveira, Santos, Isabel Anunciacao Neves dos, Trindade, Edvaldo da Silva, Veiga, Silvio Sanches   +7 more
core   +2 more sources

Proteoglycans and neuronal migration in the cerebral cortex during development and disease

Frontiers in Neuroscience, 2015
Chondroitin sulfate proteoglycans and heparan sulfate proteoglycans are major constituents of the extracellular matrix and the cell surface in the brain. Proteoglycans bind with many proteins including growth factors, chemokines, axon guidance molecules,
Nobuaki eMaeda
doaj   +1 more source

Interactions between small leucine‐rich proteoglycans and proteases: implications for tissue homeostasis and pathology

The FEBS Journal, EarlyView.
Small leucine‐rich proteoglycans (SLRPs) are key modulators of extracellular matrix structure and signaling. Their proteolytic processing by MMPs (Matrix Metalloproteinases), ADAMTS (disintegrin and metalloprotease with thrombospondin motifs), and serine proteases generates bioactive fragments that regulate collagen remodeling, inflammation, and ...
Maria Konstantaraki, Lydia‐Nefeli Thrapsanioti, Aikaterini Berdiaki, Ioanna Spyridaki, Dragana Nikitovic   +4 more
wiley   +1 more source

Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. [PDF]

, 2019
Hepcidin is a liver-derived peptide hormone that controls systemic iron homeostasis. Its expression is regulated by the bone morphogenetic protein 6 (BMP6)/SMAD1/5/8 pathway and by the proinflammatory cytokine interleukin 6 (IL6).
Anower-E-Khuda, Ferdous, Arosio, Paolo, Asperti, Michela, Denardo, Andrea, Esko, Jeffrey D, Gordts, Philip LSM, Gryzik, Magdalena, Poli, Maura, Ruzzenenti, Paola   +8 more
core  

An update on the landscape of collagen bioactive fragments

The FEBS Journal, EarlyView.
The remodeling of the extracellular matrix releases collagen bioactive fragments, which exert molecular functions and regulate numerous biological processes via several signaling pathways. Here, we summarize the latest findings describing the roles of major bioactive fragments from collagens I, IV, VI, and XVIII in various physiological and ...
Sylvie Ricard‐Blum, Julie Fradette
wiley   +1 more source

Intra-articular Injection of HB-IGF-1 Sustains Delivery of IGF-1 to Cartilage through Binding to Chondroitin Sulfate [PDF]

, 2010
Objective: Insulin-like growth factor 1 (IGF-1) stimulates cartilage repair but is not a practical therapy due to its short half-life. We have previously modified IGF-1 by adding a heparin-binding domain and have shown that this fusion protein (HB-IGF-1)
Cole, Ada A., Cummings, Kiersten, Grodzinsky, Alan J., Lee, Richard T., Miller, Rachel Elizabeth, Patwari, Parth, Plaas, Anna H. K.   +6 more
core   +1 more source