Results 71 to 80 of about 28,889 (219)

Heparan Sulfate Proteoglycans as Relays of Neuroinflammation [PDF]

Journal of Histochemistry & Cytochemistry, 2018
Heparan sulfate proteoglycans (HSPGs) are implicated as inflammatory mediators in a variety of settings, including chemokine activation, which is required to recruit circulating leukocytes to infection sites. Heparan sulfate (HS) polysaccharide chains are highly interactive and serve co-receptor roles in multiple ligand:receptor interactions.
Paul O’Callaghan, Xiao Zhang, Jin-Ping Li   +2 more
openaire   +2 more sources

Innate immunity shapes the persistent transmission of plant viruses by insect vectors

New Plant Protection, EarlyView.
In this review, we focus on two key aspects of the virus–vector interplay: (1) persistently transmitted viruses utilize host factors to overcome transmission barriers; and (2) molecular recognition activates antiviral immunity and subsequent viral counter‐defense. Understanding these interactions offers critical insights for developing novel strategies
Gang Lu, Chuanxi Zhang, Junmin Li
wiley   +1 more source

Heparan sulfate proteoglycans regulate autophagy in Drosophila [PDF]

Autophagy, 2017
Heparan sulfate-modified proteoglycans (HSPGs) are important regulators of signaling and molecular recognition at the cell surface and in the extracellular space. Disruption of HSPG core proteins, HS-synthesis, or HS-degradation can have profound effects on growth, patterning, and cell survival.
Reynolds-Peterson, Claire E., Zhao, Na, Xu, Jie, Serman, Taryn M., Xu, Jielin, Selleck, Scott B.   +5 more
openaire   +2 more sources

Heparanase regulates levels of syndecan-1 in the nucleus.

PLoS ONE, 2009
Syndecan-1 is a transmembrane heparan sulfate-bearing proteoglycan known to regulate multiple biological functions at the cell surface and within the extracellular matrix.
Ligong Chen, Ralph D Sanderson
doaj   +1 more source

Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth

Neoplasia: An International Journal for Oncology Research, 2016
In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling. However, little is known regarding the genetic and functional importance of glycan chains displayed by ...
Roland El Ghazal, Xin Yin, Scott C. Johns, Lee Swanson, Monica Macal, Pradipta Ghosh, Elina I. Zuniga, Mark M. Fuster   +7 more
doaj   +1 more source

Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1

Biomolecules, 2020
Syndecan-1 is a transmembrane heparan sulfate proteoglycan which is indispensable in the structural and functional integrity of epithelia. Normal hepatocytes display strong cell surface expression of syndecan-1; however, upon malignant transformation ...
Péter Hollósi, Lóránd Váncza, Katalin Karászi, Katalin Dobos, Bálint Péterfia, Enikő Tátrai, Péter Tátrai, Tibor Szarvas, Sándor Paku, László Szilák, Ilona Kovalszky   +10 more
doaj   +1 more source

Congenital Disorders of Deficiency in Glycosaminoglycan Biosynthesis

Frontiers in Genetics, 2021
Glycosaminoglycans (GAGs) including chondroitin sulfate, dermatan sulfate, and heparan sulfate are covalently attached to specific core proteins to form proteoglycans, which are distributed at the cell surface as well as in the extracellular matrix ...
Shuji Mizumoto, Shuhei Yamada
doaj   +1 more source

Controlled Triazine‐Based Covalent Functionalization of Black Phosphorus for Degradable Hybrid Materials

Small, EarlyView.
A scalable triazine‐based covalent functionalization strategy of black phosphorus nanosheets provides controlled P‐N surface chemistry with enhanced grafting density in the presence of a phase‐transfer catalyst. As a representative example, BP‐sulfated polymer conjugates exhibit strong in vitro antiviral activity against enveloped viruses and ...
Jasmin Er, Sreejita Ray, Enyu Xie, Robert Schusterbauer, Maik Rosentreter, Ranen Etouki, Na Xing, Anja Wiesner, Philip Nickl, Rameez Ahmed, Taylor Page, Ana Hočevar, Obida Bawadkji, Andreas Herrmann, Jörg Radnik, Vasile‐Dan Hodoroaba, Christian Sieben, Beate Paulus, Ievgen S. Donskyi   +18 more
wiley   +1 more source

Chemical Tumor Biology of Heparan Sulfate Proteoglycans [PDF]

Current Chemical Biology, 2010
Heparan sulfate proteoglycans (HSPGs) play vital roles in every step of tumor progression allowing cancer cells to proliferate, escape from immune response, invade neighboring tissues, and metastasize to distal sites away from the primary site. Several cancers including breast, lung, brain, pancreatic, skin, and colorectal cancers show aberrant ...
Karthik, Raman, Balagurunathan, Kuberan
openaire   +2 more sources

Heparanase affects food intake and regulates energy balance in mice.

PLoS ONE, 2012
Mutation of the melanocortin-receptor 4 (MC4R) is the most frequent cause of severe obesity in humans. Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan.
Linda Karlsson-Lindahl, Linnéa Schmidt, David Haage, Caroline Hansson, Magdalena Taube, Emil Egecioglu, Ying-xia Tan, Therese Admyre, John-Olov Jansson, Israel Vlodavsky, Jin-Ping Li, Ulf Lindahl, Suzanne L Dickson   +12 more
doaj   +1 more source