Results 61 to 70 of about 28,889 (219)

N-terminal syndecan-2 domain selectively enhances 6-O heparan sulfate chains sulfation and promotes VEGFA165-dependent neovascularization

Nature Communications, 2019
Proteoglycans are glycosylated proteins that play a number of structural and signalling functions. Here, Corti, Wang et al. show that the N-terminal sequence of proteoglycan Syndecan-2 selectively increases 6-O sulfation of its heparan sulfate chains ...
Federico Corti, Yingdi Wang, John M. Rhodes, Deepak Atri, Stephanie Archer-Hartmann, Jiasheng Zhang, Zhen W. Zhuang, Dongying Chen, Tianyun Wang, Zhirui Wang, Parastoo Azadi, Michael Simons   +11 more
doaj   +1 more source

Endothelial glycocalyx degradation during sepsis: Causes and consequences

Matrix Biology Plus, 2021
The glycocalyx is a ubiquitous structure found on endothelial cells that extends into the vascular lumen. It is enriched in proteoglycans, which are proteins attached to the glycosaminoglycans heparan sulfate, chondroitin sulfate, dermatan sulfate ...
Ryan C. Sullivan, Matthew D. Rockstrom, Eric P. Schmidt, Joseph A. Hippensteel   +3 more
doaj   +1 more source

WONOEP XVII appraisal: The role of the extracellular matrix in epilepsy

Epilepsia, EarlyView.
Abstract The extracellular matrix (ECM) is composed of proteoglycans and glycoproteins that regulate the external environment surrounding neurons, glia, and the vascular system. The ECM is vital for maintaining the structure and function of the brain and also acts as a reservoir for various signaling molecules and neurotransmitters, modulating synaptic
Eleonora Lugara, Erwin A. van Vliet, Alessia Romagnolo, Kevin Staley, Kyle P. Lillis, Chris Dulla, David C. Henshall, Katja Kobow   +7 more
wiley   +1 more source

A monoclonal antibody that blocks the activity of a neurite regeneration-promoting factor: studies on the binding site and its localization in vivo [PDF]

, 1986
Work from several laboratories has identified a proteoglycan complex secreted by a variety of non-neuronal cells that can promote neurite regeneration when applied to the surface of culture dishes.
Chiu, Arlene Y., Matthew, William D., Patterson, Paul H.   +2 more
core   +1 more source

Distinctive populations of basement membrane and cell membrane heparan sulfate proteoglycans are produced by cultured cell lines [PDF]

, 1987
. We have investigated the nature and distribution of different populations of heparan sulfate proteoglycans (HSPGs) in several cell lines in culture. Clone 9 hepatocytes and NRK and CHO cells were biosynthetically labeled with 35SO4, and proteoglycans ...
Farquhar, M. G., Stow, J. L.
core   +3 more sources

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation [PDF]

, 2019
Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans.
Morla, Shravan
core   +1 more source

Discovery of a Novel Molecule that Regulates Tumor Growth and Metastasis

The Scientific World Journal, 2008
The heparan sulfate proteoglycan, Glypican-1 (GPC1), significantly impacts the growth of pancreatic cancer cells in vivo and markedly attenuates tumor angiogenesis and metastasis in athymic mice.
Chery A. Whipple, Arthur D. Lander, Murray Korc   +2 more
doaj   +1 more source

Agrin binds to the nerve-muscle basal lamina via laminin [PDF]

, 1997
Agrin is a heparan sulfate proteoglycan that is required for the formation and maintenance of neuromuscular junctions. During development, agrin is secreted from motor neurons to trigger the local aggregation of acetylcholine receptors (AChRs) and other ...
Altschul, Bowe, Bowe, Bowen, Brancaccio, Brandenberger, Brandenberger, Brubacher, Burden, Burgeson, Campagna, Campanelli, Campbell, Chiu, Cohen, Cohen, Denzer, Denzer, Ferns, Fox, Gautam, Gee, Gesemann, Gesemann, Gluzman, Godfrey, Godfrey, Godfrey, Godfrey, Graham, Hagen, Halfter, Hall, Hunter, Kleinman, Lennon, Lowry, Magill-Solc, Martin, Martin, McMahan, McMahan, Morrissey, Nitkin, Nitkin, Noakes, Ott, Paulsson, Pearson, Perris, Reist, Ries, Ruegg, Ruegg, Ruegg, Rupp, Sanes, Sanes, Sanes, Schuler, Smith, Sugiyama, Timpl, Timpl, Timpl, Tsen, Tsen, Tsim, Wallace, Wallace, Weber, Worton, Yurchenco, Yurchenco   +73 more
core   +3 more sources

Engineering exosomal cargo loading via endogenous molecular pathways: Strategies to enhance therapeutic potential

Interdisciplinary Medicine, EarlyView.
This review illustrates how scientists engineer exosomes by hijacking the cell's own cargo‐sorting machinery. These strategies efficiently load therapeutic molecules into natural vesicles, creating powerful next‐generation drug delivery systems (Created with BioGDP.com).
Huanrong Zhu, Chenning Zhang, Shihan Ma, Zhanxue Xu, Cailing Liang, Fang Cheng, Hongbo Chen   +6 more
wiley   +1 more source