Results 51 to 60 of about 250,900 (178)

Role of Heparan Sulfate in Immune System-Blood Vessel Interactions

, 1993
Heparan sulfate proteoglycan, a component of endothelial cell membranes and extracellular matrices, is involved in a number of the critical functions of endothelium and of antigen-presenting cells.
Wrenshall, Lucile E., Lindman, Bonnie J., Jeffrey L. Platt, Ihrcke, Nathan S., Bonnie J. Lindman, Platt, Jeffrey L., Nathan S. Ihrcke, Lucile E. Wrenshall   +7 more
core   +1 more source

Heparan sulfate proteoglycans undergo differential expression alterations in left sided colorectal cancer, depending on their metastatic character

BMC Cancer, 2018
Background Heparan sulfate proteoglycans (HSPGs) are complex molecules which play a role in the invasion and growth and metastatic properties of cancerous cells.
Ainara Crespo, Olivia García-Suárez, Iván Fernández-Vega, María Pilar Solis-Hernandez, Beatriz García, Sonia Castañón, Luis M. Quirós   +6 more
doaj   +1 more source

Heparan sulfate proteoglycans fine-tune macrophage inflammation via IFN-β [PDF]

, 2014
Macrophages are important mediators of diseases associated with metabolic inflammation such as obesity and atherosclerosis. In this Stimulus we discuss recent findings showing that heparan sulfate proteoglycans on macrophages serve as an important ...
Gordts, Philip LSM, Esko, Jeffrey D, Gordts, PLSM, Esko, JD   +3 more
core   +2 more sources

Heparanase regulates levels of syndecan-1 in the nucleus.

PLoS ONE, 2009
Syndecan-1 is a transmembrane heparan sulfate-bearing proteoglycan known to regulate multiple biological functions at the cell surface and within the extracellular matrix.
Ligong Chen, Ralph D Sanderson
doaj   +1 more source

Syndecan-1 Promotes Hepatocyte-Like Differentiation of Hepatoma Cells Targeting Ets-1 and AP-1

Biomolecules, 2020
Syndecan-1 is a transmembrane heparan sulfate proteoglycan which is indispensable in the structural and functional integrity of epithelia. Normal hepatocytes display strong cell surface expression of syndecan-1; however, upon malignant transformation ...
Péter Hollósi, Lóránd Váncza, Katalin Karászi, Katalin Dobos, Bálint Péterfia, Enikő Tátrai, Péter Tátrai, Tibor Szarvas, Sándor Paku, László Szilák, Ilona Kovalszky   +10 more
doaj   +1 more source

Essential regulation of heparan sulfate proteoglycan signalling controls cell behaviour to support cardiac development

Heparan sulfate proteoglycan (HSPG)-dependent signalling is essential for cardiac development, yet how HSPGs are regulated in the forming heart is unknown. Here, we show that the extracellular heparan sulfate modifier, SULF1, expressed by the epicardium,
Redpath AN, Lupu I, Haffreingue L, Dang Q, McCracken IR, Carsana T, van Kuppevelt TH, Vieira JM, Smart N.   +8 more
europepmc   +2 more sources

Mechanism study of an articular cartilage repair material and its forward‐looking test for space medicine

BMEMat, EarlyView.
The regeneration process following dLhCG engraftment progressed through four distinct and interconnected stages. dLhCG maintained its regenerative efficacy after 6 months of cosmic exposure, supporting its potential application in space medicine.
Xu Hu, Hang Yao, Zhen Zhang, Zhonglian Wu, Huiqun Zhou, Bangheng Liu, Liang Ma, Yulei Mu, Dong‐An Wang   +8 more
wiley   +1 more source

High resolution immunoelectron microscopic localization of functional domains of laminin, nidogen, and heparan sulfate proteoglycan in epithelial basement membrane of mouse cornea reveals different topological orientations [PDF]

, 1988
Thin and ultrathin cryosections of mouse cornea were labeled with affinity-purified antibodies directed against either laminin, its central segments (domain 1), the end of its long arm (domain 3), the end of one of its short arms (domain 4), nidogen, or ...
Engel, Jürgen, Schittny, Johannes C., J Engel, J C Schittny, Timpl, Rupert, R Timpl, Engel J, Schittny JC, Timpl R   +8 more
core   +1 more source

Heparanase affects food intake and regulates energy balance in mice.

PLoS ONE, 2012
Mutation of the melanocortin-receptor 4 (MC4R) is the most frequent cause of severe obesity in humans. Binding of agouti-related peptide (AgRP) to MC4R involves the co-receptor syndecan-3, a heparan sulfate proteoglycan.
Linda Karlsson-Lindahl, Linnéa Schmidt, David Haage, Caroline Hansson, Magdalena Taube, Emil Egecioglu, Ying-xia Tan, Therese Admyre, John-Olov Jansson, Israel Vlodavsky, Jin-Ping Li, Ulf Lindahl, Suzanne L Dickson   +12 more
doaj   +1 more source

Glycan Sulfation Modulates Dendritic Cell Biology and Tumor Growth

Neoplasia: An International Journal for Oncology Research, 2016
In cancer, proteoglycans have been found to play roles in facilitating the actions of growth factors, and effecting matrix invasion and remodeling. However, little is known regarding the genetic and functional importance of glycan chains displayed by ...
Roland El Ghazal, Xin Yin, Scott C. Johns, Lee Swanson, Monica Macal, Pradipta Ghosh, Elina I. Zuniga, Mark M. Fuster   +7 more
doaj   +1 more source