Results 141 to 150 of about 17,189 (225)

Herpesvirus Simplex Virus‐1 Exploits Inflammation to Infect Periodontal Stem Cells and Disrupt Lineage Commitment

open access: yesJournal of Periodontal Research, EarlyView.
HSV‐1 infects oral mesenchymal stem cells both in vitro and in vivo to dysregulate their lineage commitment. An inflamed gingival environment increases susceptibility to HSV‐1 infection, which further elevates proinflammatory cytokine levels and exacerbates alveolar bone loss.
Araceli Valverde   +9 more
wiley   +1 more source

The causative role of amyloidosis in the cardiac complications of Alzheimer's disease: a comprehensive systematic review

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Schematic illustration of the bidirectional causative link between cerebral amyloid‐beta (Aβ) angiopathy and cardiovascular disease in Alzheimer's disease (AD). Common cardiovascular risk factors like microvascular thrombosis, diabetes, atrial fibrillation, hypertension and atherosclerosis lead to cerebral hypoperfusion and ...
Samuel Parker   +2 more
wiley   +1 more source

Association of heparan sulfate proteoglycan with the neurofibrillary tangles of Alzheimer's disease [PDF]

open access: hybrid, 1991
George Perry   +9 more
openalex   +1 more source

Glycosaminoglycans and Glycosaminoglycan Mimetics in Cancer and Inflammation [PDF]

open access: yes, 2019
Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all mammalian cells and usually covalently attached to proteins, forming proteoglycans.
Morla, Shravan
core   +1 more source

Interaction between nuclear‐translocated cellular communication network factor 2 and purine‐rich box 1 regulates the expression of fibrosis‐related genes

open access: yesJournal of Cell Communication and Signaling, Volume 19, Issue 4, December 2025.
Although cellular communication network factor 2 (CCN2) is secreted out to the extracellular environment, intracellular CCN2 rather than re‐incorporated CCN2 from the outside may be involved in its translocation into the nuclei, because translocation of CCN2 into the nucleus was not disturbed by soluble heparin.
Xuan Thi Nguyen   +3 more
wiley   +1 more source

Association Between Serum Syndecan 1 Levels and Metabolic Syndrome Parameters: A Comparative Cross‐Sectional Study

open access: yesEndocrinology, Diabetes &Metabolism, Volume 8, Issue 6, November 2025.
The results revealed that men in the MetS+ HTN+ ALT+ group had significantly higher serum SDC1 levels than women (20.19 ± 10.56 vs. 11.82 ± 5.09 ng/mL, p = 0.020). Furthermore, in both the total study sample and the MetS+ HTN+ ALT+ group, SDC1 concentrations were positively correlated with diastolic blood pressure (r = 0.256, p = 0.021; r = 0.463, p ...
Shima Tavalaie   +9 more
wiley   +1 more source

Small Extracellular Vesicles From Radioresistant H3K27M‐Pediatric Diffuse Midline Glioma Cells Modulate Tumor Phenotypes and Radiation Response

open access: yesJournal of Extracellular Vesicles, Volume 14, Issue 11, November 2025.
Radioresistant H3K27M‐pediatric diffuse midline glioma‐derived extracellular vesicles enhance DNA repair and trigger metabolic and transcriptional changes in radiosensitive tumor cells. These findings reveal vesicle‐mediated intratumoral communication as a driver of intrinsic radioresistance and suggest novel targets to disrupt therapy‐resistant ...
Viral D. Oza   +6 more
wiley   +1 more source

Decoding Glycosylation in Neurodegenerative Diseases: Mechanistic Insights and Therapeutic Opportunities

open access: yesThe FASEB Journal, Volume 39, Issue 20, 31 October 2025.
Graphical summary of glycosylation impairments in various neurodegenerative disorders. Among the diverse forms of glycosylation, the most extensively studied include N‐glycosylation, O‐glycosylation, and O‐GlcNAcylation. Aberrant glycosylation has been implicated in multiple neurodegenerative conditions.
Haihan Yu   +5 more
wiley   +1 more source

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