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Heparan Sulfate Proteoglycans Are Receptors for Extracellular HIV-1 Tat Internalization
, 2001 Masayuki Ishihara
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Heparan Sulfate Proteoglycans in Diabetes [PDF]
Seminars in Thrombosis and Hemostasis, 2021 AbstractDiabetes is a complex disorder responsible for the mortality and morbidity of millions of individuals worldwide. Although many approaches have been used to understand and treat diabetes, the role of proteoglycans, in particular heparan sulfate proteoglycans (HSPGs), has only recently received attention.
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Development of Molecules Antagonizing Heparan Sulfate Proteoglycans [PDF]
Seminars in Thrombosis and Hemostasis, 2021 AbstractHeparan sulfate proteoglycans (HSPGs) occur in almost every tissue of the human body and consist of a protein core, with covalently attached glycosaminoglycan polysaccharide chains. These glycosaminoglycans are characterized by their polyanionic nature, due to sulfate and carboxyl groups, which are distributed along the chain.
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Alzheimer s disease and heparan sulfate proteoglycan
Frontiers in Bioscience, 1998Alzheimer's disease (AD) is a debilitating neurodegenerative disorder. Cardinal histopathologic changes of AD are neurofibrillary tangles (NFTs) and deposits of beta-amyloid protein (A-beta) in the form of neuritic plaques (NPs). Several different mutations found in patients with familial AD have been demonstrated to increase A-beta production ...
Ling Li, M. Hart, Ken-ichiro Fukuchi
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Heparan Sulfate Proteoglycans in Amyloidosis
2010Amyloidosis is a generic term for a group of diseases characterized by deposits in different organ systems of insoluble materials composed mainly of distinct fibrillar proteins named amyloid. Besides amyloid, heparan sulfate proteoglycan (HSPG), is commonly found in most amyloid deposits, suggesting that HS/HSPG may be functionally involved in the ...
Xiao Zhang, Jin-Ping Li
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Binding of Rat Thyroglobulin to Heparan Sulfate Proteoglycans
Thyroid, 2000We previously showed that rat thyroglobulin (Tg) is a heparin-binding protein and that heparin inhibits Tg binding to megalin (gp330), an endocytic Tg receptor found on the apical surface of thyrocytes. Cooperation between cell surface receptors and heparin-like molecules, namely heparan sulfate proteoglycans (HSPGs), can facilitate cell surface ...
MARINO', MICHELE +2 more
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Integral membrane heparan sulfate proteoglycans
The FASEB Journal, 1993Heparan sulfate is a regulatory polysaccharide. It modulates specific growth factor-receptor interactions, accelerates the formation of specific proteinase-proteinase inhibitor complexes, and mediates interactions of the cell surface with several enzymes and structural proteins.
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Heparan sulfate proteoglycans in invasion and metastasis
Seminars in Cell & Developmental Biology, 2001Because heparan sulfate proteoglycans mediate cell adhesion and control the activities of numerous growth and motility factors, they play a critical role in regulating the metastatic behavior of tumor cells. Due to their utilitarian nature, heparan sulfate proteoglycans may at times act as inhibitors of cell invasion and at other times as promoters of ...
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Alterations of Heparan Sulfate Proteoglycans in Cancer [PDF]
Journal of Glycobiology, 2015 Heparan sulfate proteoglycans (HSPGs) are glycoproteins, with the common characteristic of containing covalently attached heparan sulfate glycosaminoglycan chains (GAGs). These molecules are highly modified in cancer, contributing to tumorigenesis.
Sonia Castañón +4 more
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